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Comparison of the efficacy of a combination of high dose metoclopramide and dexamethasone, with that of haloperidol, midazolam and dexamethasone, for the prevention of postoperative nausea and vomiting in laparoscopic gynecologic surgery

Jee YS, Yoon HJ, Park YS, Kim DW

BACKGROUND: This prospective randomized double-blinded study was designed to compare the efficacy of a combination of high dose metoclopramide and dexamethasone with that of haloperidol, midazolam and dexamethasone, for the...
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Development and validation of a HPLC-UV method for 4-(4-chlorophenyl)-4-hydroxypiperidine (CPHP), a toxic metabolite of haloperidol, in humans: providing in vivo evidence of CYP3A4-mediated CPHP formation

Park JY, Shin JG

We developed a high-performance liquid chromatographic procedure for the determination of 4-(4-chlorophenyl)-4-hydroxypiperidine (CPHP), a toxic metabolite of haloperidol, in human. Chromatographic analysis was performed on a reverse-phase C₁₈ column with...
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Differential Effects of Olanzapine and Haloperidol on MK-801-induced Memory Impairment in Mice

Song JC, Seo MK, Park SW, Lee JG, Kim YH

OBJECTIVE: We investigated the differential effects of the antipsychotic drugs olanzapine and haloperidol on MK-801-induced memory impairment and neurogenesis in mice. METHODS: MK-801 (0.1 mg/kg) was administered 20 minutes prior to...
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Effects of Clozapine, Haloperidol, and Fluoxetine on the Reversal of Cocaine-Induced Locomotor Sensitization

Cha SK, Kang UG

OBJECTIVE: Repeated treatment with psychostimulants induces sensitization of the dopaminergic system in the brain. Dopaminergic sensitization has been proposed as a mechanism of psychosis. Although antipsychotics block the expression of...
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Comparison of the Clinical Efficacy and Safety between Intramuscular Olanzapine and Intramuscular Haloperidol Injection in the Treatment of Delirium

Lim HK, Paik IH, Oh K, Lee CU, Lee C

  • KMID: 2286703
  • Korean J Psychopharmacol.
  • 2007 Nov;18(6):423-428.
OBJECTIVE: The present study aimed to provide preliminary data on the effectiveness and tolerability of intramuscular (IM) olanzapine and IM haloperidol for patients with delirium. METHODS: Sixty-two patients with delirium were...
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Effects of Haloperidol on [Ca2+]i Change in HIT T-15 Insulinoma Cells

Kim MH, Park KC, Jin SY, Kim DR, Kim MJ, Park KS, Kong ID

  • KMID: 2287031
  • Korean J Psychopharmacol.
  • 2007 Sep;18(5):288-298.
OBJECTIVE: The purpose of this study was to investigate the effects of haloperidol on [Ca2+]i in hamster insulinoma cells (HIT T-15). METHODS: [Ca2+]i levels were measured by calcium imaging techniques, and...
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Comparison of Efficacy between Aripiprazole and Haloperidol in the Treatment of Patients with Delirium

Lee CS, Rim GM, Hahn KH, Kim BJ

  • KMID: 2287070
  • Korean J Psychopharmacol.
  • 2007 Jul;18(4):240-245.
OBJECTIVE: Delirium is defined as an alteration in mental status characterized by brief disturbances in consciousness and attention, cognition, and perception that tend to fluctuate during the course of the...
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Risperdal Sachet and Oral Lorazepam versus Intramuscular Haloperidol and Lorazepam Injection for Acute Psychotic Symptom in the Elderly Patients with Organic Mental Disorder

Youn T

  • KMID: 2249212
  • Korean J Biol Psychiatry.
  • 2007 May;14(2):99-105.
OBJECTIVES: The purpose of present study was to investigate the effect, safety and tolerability of risperdal sachet(oral solution) with lorazepam tablet versus intramuscular haloperidol and lorazepam injection for management of...
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The Influences of Risperidone and Clozapine on Body Weight and Glucose Level in Patients with Chronic Schizophrenia: Comparison Study with Haloperidol

Nam CW, Yang BH, Lee JN

  • KMID: 2248981
  • Korean J Biol Psychiatry.
  • 2004 Nov;11(2):127-135.
OBJECT: The goal of this study was to examine the changes in body weight and glucose levels of the patients treated with risperidone, clozapine or haloperidol in order to compare...
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Effects of Haloperidol and Risperidone on the Subjective Quality of Life in Stable Chronic Schizophrenic Patients

Min SK, Park JK, Suh SY, Kim DK

  • KMID: 2340643
  • J Korean Neuropsychiatr Assoc.
  • 2002 Jan;41(1):76-83.
OBJECTIVE: The purpose of this study is to compare the effects of haloperidol and risperidone on the quality of life in chronic schizophrenic patients and to identify how the...
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Effects of Coadministraion of (-)-3-PPP and Haloperidol on the c-fos Expression in the Nucleus Accumbens and Prefrontal Cortex of Rats

Park KH, Chung YC, Eun HB, Park TW

  • KMID: 1607281
  • Korean J Psychopharmacol.
  • 2001 Jun;12(2):133-139.
OBJECTIVE: The purpose of our study was to measure and compare the c-fos mRNA expression patterns in the nucleus accumbens (NAS) and prefrontal cortex (PFC) of rats after the administration...
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Prolactin Response to the Administration of Risperidone and haloperidol in Patients with Schizophrenia and Other Psychotic Disorder

Chung YC, Park KH, Kim DJ, Park KY

  • KMID: 2286939
  • Korean J Psychopharmacol.
  • 2000 Dec;11(4):343-349.
The purposes of this study were to compare the difference of prolactin responses to risperidone and haloperidol, the sex difference in prolactin responses to each drug and the difference of...
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Comparison of Therapeutic Efficacy between Haloperidol and Risperidone in Tic Disorders

Oh EY, Shin YM, Lee MS, Chung YK, Park JH

  • KMID: 2037079
  • Korean J Psychopharmacol.
  • 2000 Sep;11(3):270-177.
Tourette's syndrome is a heritable neuropsychiatric disorder that begins in childhood. No known medication suppresses tics completely, and the dopamine receptor antagonists-haloperidol and pimozide-for Tourette's syndrome often either produce or...
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Effects of Haloperidol Decanoate Treatment on the Rat Brain: Morphological and Neurochemical Study

Chung YC, Lee KH, Eun HB, Park KY, Uhm TB, Kim HT, Han EH

  • KMID: 2286946
  • Korean J Psychopharmacol.
  • 2000 Jun;11(2):136-144.
Using vacuous chewing movement(VCM) of rats as a possible animal model for tardive dyskinesia(TD), we tried to investigate the effects of haloperidol decanoate treatment on the rat brain: VCM(+) incidence, and morphological...
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The Effect of Haloperidol on Regional Cerebral Blood Flow Assessed with 99m-Tc-ECD SPECT In Schizophrenic Patients

Cheon KA, Lee JD, Min SK, Kim SJ, Ahn SK

  • KMID: 2340346
  • J Korean Neuropsychiatr Assoc.
  • 1999 Jul;38(4):861-872.
OBJECTIVES: Regional cerebral blood flow(rCBF)in schizophrenics is confounded by various factors including medication status. Previously, there have been numerous studies regarding the effects of antipsychotics on rCBF. However, these...
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Comparison of Therapeutic Effects actor Side Effects between Nemonapride and Haloperidol Treated Schizophrenic Patients

Suh KH, Lee HS, Cheong HK, Kim KH, Kim BJ, Chang DW, Kim L

  • KMID: 2287011
  • Korean J Psychopharmacol.
  • 1999 Apr;10(1):40-49.
OBJECTIVE: This open prospective study was performed to investigate the therapeutic efforts and side effects profiles of nemonapride in the schizophrenic patients, and was compared with one of typical anti-psychotics,...
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Effects of dopamine and haloperidol on morphine-induced CREB and AP-1 DNA binding activities in differentiated SH-SY5Y human neuroblastoma cells

Kim SK, Kwon GY

  • KMID: 2071825
  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):671-676.
In the present study, we first examined whether the changes in the DNA binding activities of the transcription factors, cAMP response element binding protein (CREB) and activator protein-1 (AP-1) mediate the long-term effects...
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Therapeutic Effect of Risperidone on the Refractory Schizophrenia: a Single-Blinded Comparison with Haloperidol

Lee KW, Yoon TH, Lee C, Jang KY, Seong KS, Song IJ

  • KMID: 2340231
  • J Korean Neuropsychiatr Assoc.
  • 1998 Nov;37(6):1111-1120.
OBJECTIVES: We attempted to investigate clinical efficacy of risperidone a new antipsychotic agent with high safety and without life-threatening side effect such as agranulocytosis, in refractory schizophrenia compared with a...
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The Effects of Bethanechol on Anticholinergic Side Effects of Haloperidol

Son SC, Kim JS, Kim SH, Joe SH, Choi YT

  • KMID: 1985342
  • Korean J Psychopharmacol.
  • 1998 Oct;9(2):153-161.
OBJECTIVES: Haloperidol has been widely used for treating schizophrenia with somewhat limitation due to the side effects. Some of these side effects are anticholinergic side effects such as dry mouth,...
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Effects of Nemonapride on Cognitive and Psychomotor Performance and Sedation in Normal Adults: A Comparison with Chlorpromazine, Haloperidol and Placebo

Yoon BH, Yoon JS, Park SW

  • KMID: 1985338
  • Korean J Psychopharmacol.
  • 1998 Oct;9(2):119-130.
This study was done to compare the effects of nemonapride on cognitive and psychomotor performance and sedation with those of classical antipsychotics in normal adults. Single doses of three antipsychotics...
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