- Combination of In Vivo [¹²³I]FP-CIT SPECT and Microdialysis Reveals an Antipsychotic Drug Haloperidol-induced Synaptic Dopamine Availability in the Rat Midbrain and Striatum
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Park SH, Song YS, Moon BS, Lee BC, Park HS, Kim SE
- KMID: 2463715
- Exp Neurobiol.
- 2019 Oct;28(5):602-611.
- doi: 10.5607/en.2019.28.5.602
Synaptic dopamine (DA) is mainly regulated by the presynaptic DA transporter (DAT). Single-photon emission computerized tomography (SPECT) with the DAT radiotracer [¹²³I]FP-CIT assesses changes in synaptic DA availability when endogenous... -
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- Comparison of the efficacy of a combination of high dose metoclopramide and dexamethasone, with that of haloperidol, midazolam and dexamethasone, for the prevention of postoperative nausea and vomiting in laparoscopic gynecologic surgery
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Jee YS, Yoon HJ, Park YS, Kim DW
- KMID: 2436035
- Anesth Pain Med.
- 2018 Jul;13(3):278-285.
- doi: 10.17085/apm.2018.13.3.278
BACKGROUND: This prospective randomized double-blinded study was designed to compare the efficacy of a combination of high dose metoclopramide and dexamethasone with that of haloperidol, midazolam and dexamethasone, for the... -
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- Effects of Tianeptine on Adult Rats Following Prenatal Stress
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Lee H, Kim HK, Kwon JT, Kim YO, Seo J, Lee S, Cho IH, Kim HJ
- KMID: 2412389
- Clin Psychopharmacol Neurosci.
- 2018 May;16(2):197-208.
- doi: 10.9758/cpn.2018.16.2.197
OBJECTIVE: Exposing a pregnant female to stress during the critical period of embryonic fetal brain development increases the risk of psychiatric disorders in the offspring. The objective of this study... -
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- A Study on Discontinuation Rate on Maintenance Treatment of Antipsychotic Agents in Schizophrenic Patients
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Bae HH, NA EH, Yoon HJ, Park EK, Lee JI
- KMID: 2395442
- Korean J Schizophr Res.
- 2017 Oct;20(2):69-76.
- doi: 10.16946/kjsr.2017.20.2.69
OBJECTIVES: Relapse prevention is a major therapeutic goal in the treatment of schizophrenia. However, many patients experience multiple functional impairments and treatment resistance due to recurrence. This study was designed... -
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- Galactorrhea Probably Related with Switching from Osmotic-release Oral System Methylphenidate (MPH) to Modified-release MPH: An Adolescent Case
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Ekinci O, Gunes S, Ekinci N
- KMID: 2388276
- Clin Psychopharmacol Neurosci.
- 2017 Aug;15(3):282-284.
- doi: 10.9758/cpn.2017.15.3.282
Galactorrhea, as an adverse effect of psychotropic medications, usually develops due to high dose of antipsychotics. Selective serotonin reuptake inhibitors (SSRIs) have also been reported to be related to galactorrhea.... -
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- Prevalence of Metabolic Syndrome in Patients with Schizophrenia in Korea: A Multicenter Nationwide Cross-Sectional Study
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Lee JS, Kwon JS, Kim D, Kim SW, Kim JJ, Kim JH, Nam HJ, Ryu S, Park IH, An SK, Oh HS, Won S, Lee K, Lee KY, Lee SH, Lee YS, Yi JS, Hong KS, Joo YH
- KMID: 2365011
- Psychiatry Investig.
- 2017 Jan;14(1):44-50.
- doi: 10.4306/pi.2017.14.1.44
OBJECTIVE: We designed a nationwide study with limited exclusion criteria to investigate the prevalence of metabolic syndrome (MetS) in Korea and its relationship with antipsychotic medications. METHODS: This multicenter, cross-sectional, and... -
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- Venous Thromboembolism Following Dantrolene Treatment for Neuroleptic Malignant Syndrome
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Chen PH, Lane HY, Lin CH
- KMID: 2356168
- Clin Psychopharmacol Neurosci.
- 2016 Nov;14(4):399-401.
- doi: 10.9758/cpn.2016.14.4.399
Neuroleptic malignant syndrome (NMS) is one of the most severe iatrogenic emergencies in clinical service. The symptoms including sudden consciousness change, critical temperature elevation and electrolytes imbalance followed by mutli-organ... -
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- Development and validation of a HPLC-UV method for 4-(4-chlorophenyl)-4-hydroxypiperidine (CPHP), a toxic metabolite of haloperidol, in humans: providing in vivo evidence of CYP3A4-mediated CPHP formation
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Park JY, Shin JG
- KMID: 2351802
- Transl Clin Pharmacol.
- 2016 Sep;24(3):147-151.
- doi: 10.12793/tcp.2016.24.3.147
We developed a high-performance liquid chromatographic procedure for the determination of 4-(4-chlorophenyl)-4-hydroxypiperidine (CPHP), a toxic metabolite of haloperidol, in human. Chromatographic analysis was performed on a reverse-phase Câ‚₈ column with... -
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- Delirium Management: Diagnosis, Assessment, and Treatment in Palliative Care
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Seo MS, Lee YJ
- KMID: 2351383
- Korean J Hosp Palliat Care.
- 2016 Sep;19(3):201-210.
- doi: 10.14475/kjhpc.2016.19.3.201
Delirium is a common symptom in patients with terminal cancer. The prevalence increases in the dying phase. Delirium causes negative effects on quality of life for both patients and their... -
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- Differential Effects of Olanzapine and Haloperidol on MK-801-induced Memory Impairment in Mice
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Song JC, Seo MK, Park SW, Lee JG, Kim YH
- KMID: 2348476
- Clin Psychopharmacol Neurosci.
- 2016 Aug;14(3):279-285.
- doi: 10.9758/cpn.2016.14.3.279
OBJECTIVE: We investigated the differential effects of the antipsychotic drugs olanzapine and haloperidol on MK-801-induced memory impairment and neurogenesis in mice. METHODS: MK-801 (0.1 mg/kg) was administered 20 minutes prior to... -
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- Retrospective Cohort Study on the Administration of Sedative for Delirium in Terminally Ill Cancer Patients and Survival Time
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Park HS, Kim DS, Bae EH, Kim JR, Seo JH, Yun JM
- KMID: 2165141
- Korean J Hosp Palliat Care.
- 2016 Jun;19(2):119-126.
- doi: 10.14475/kjhpc.2016.19.2.119
PURPOSE: This study analyzed the difference in survival time of patients with delirium according to sedative medication. METHODS: From January 2012 through December 2013, a retrospective cohort study was performed using... -
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- Hemichorea following Temporo-Parietal Infarction
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Oh DA, Lee E, Kim SJ, Park HK, Rha JH, Yoon CW
- KMID: 2163258
- J Korean Neurol Assoc.
- 2016 May;34(2):130-132.
- doi: 10.17340/jkna.2016.2.7
Hemichorea after cortical infarction has rarely been reported. We report a female patient in which hemichorea of the right extremities developed following a left temporo-parietal infarction. An acute infarction in... -
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- Antipsychotic Prescribing Patterns in First-episode Schizophrenia: A Five-year Comparison
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Roh D, Chang JG, Yoon S, Kim CH
- KMID: 2171029
- Clin Psychopharmacol Neurosci.
- 2015 Dec;13(3):275-282.
- doi: 10.9758/cpn.2015.13.3.275
OBJECTIVE: Early treatment choice is critical in first-episode schizophrenia-spectrum disorders. The purpose of this study was to describe prescribing trends of antipsychotics use in patients with first-episode schizophrenia in 2005... -
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- A Systemic Review and Experts' Consensus for Long-acting Injectable Antipsychotics in Bipolar Disorder
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Chou YH, Chu PC, Wu SW, Lee JC, Lee YH, Sun IW, Chang CL, Huang CL, Liu IC, Tsai CF, Yen YC
- KMID: 2171041
- Clin Psychopharmacol Neurosci.
- 2015 Aug;13(2):121-128.
- doi: 10.9758/cpn.2015.13.2.121
Bipolar disorder (BD) is a major psychiatric disorder that is easily misdiagnosed. Patient adherence to a treatment regimen is of utmost importance for successful outcomes in BD. Several trials of... -
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- Frequency and Outcome of Neuroleptic Rotation in the Management of Delirium in Patients with Advanced Cancer
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Shin SH, Hui D, Chisholm G, Kang JH, Allo J, Williams J, Bruera E
- KMID: 2148488
- Cancer Res Treat.
- 2015 Jul;47(3):399-405.
- doi: 10.4143/crt.2013.229
PURPOSE: The response to haloperidol as a first-line neuroleptic and the pattern of neuroleptic rotation after haloperidol failure have not been well defined in palliative care. The purpose of this... -
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- Intensive Care Unit Delirium
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Kim Y, Hong SJ
- KMID: 2227663
- Korean J Crit Care Med.
- 2015 May;30(2):63-72.
- doi: 10.4266/kjccm.2015.30.2.63
Delirium is described as a manifestation of acute brain injury and recognized as one of the most common complications in intensive care unit (ICU) patients. Although the causes of delirium... -
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- Oromandibualr Dystonia Associated with Diabetic Hyperglycemia
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Song YM
- KMID: 2343547
- J Korean Neurol Assoc.
- 2014 Nov;32(4):259-261.
- doi: 10.0000/jkna.2014.32.4.259
Oromandibular dystonia (OMD) is a focal dystonia that is characterized by repetitive or sustained spasms of the masticatory, facial, or lingual muscles. The etiology is idiopathic in most cases. A... -
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- Effects of Clozapine, Haloperidol, and Fluoxetine on the Reversal of Cocaine-Induced Locomotor Sensitization
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Cha SK, Kang UG
- KMID: 2316373
- Psychiatry Investig.
- 2014 Oct;11(4):454-458.
- doi: 10.4306/pi.2014.11.4.454
OBJECTIVE: Repeated treatment with psychostimulants induces sensitization of the dopaminergic system in the brain. Dopaminergic sensitization has been proposed as a mechanism of psychosis. Although antipsychotics block the expression of... -
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- Comparison of Treatment Response of Antipsychotics According to Sedative Effect in the Treatment of Patients with Delirium
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Lee SJ, Jeong JH, Kim TW, Lim HK, Seo HJ, Hong SC, Han JH
- KMID: 2287764
- Korean J Psychopharmacol.
- 2014 Oct;25(4):168-174.
- doi: 10.0000/kjp.2014.25.4.168
OBJECTIVE: The purpose of the study is to compare treatment responses and side effects of antipsychotic medications in hospitalized delirium patients. METHODS: Among delirium patients hospitalized 23 less-sedating agent group and... -
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- Successful Treatment of Intractable Hiccups with Benztropine
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Kim YS, Yu HJ, Kim JY, Lee M, Lee J
- KMID: 2176753
- J Korean Child Neurol Soc.
- 2014 Sep;22(3):165-168.
In general, intractable hiccups are uncommon. Various drugs and interventions have been reported, but there is no consensus on the treatment of intractable hiccups. We report a patient with meningitis... -
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