J Korean Pediatr Soc.  2001 Feb;44(2):205-210.

A Neonatal Case of Symptomatic Congenital Cytomegalovirus Infection with Hearing Defect

• Jang SJ
• Cho YJ
• Lee SL
• Kim JS
• Kwon TC

Abstract

Cytomegalovirus(CMV) is one of the leading cause of intrauterine infections of man with an incidence ranging from 0.48% to 2.2% of all live births. Although the majority of CMV-infected newborns are clinically asymptomatic at birth, some will have signs of congenital infection : Intrauterine growth retardation, petechial or purpuric rash, microcephaly, anemia, thrombocytopenia, jaundice, hepatosplenomegaly and intracranial calcification. We experienced a case of symptomatic congenital CMV infection in a 1-day-old male who presented generalized petechiae, hepatosplenomegaly, anemia, thrombocytopenia. Urine PCR and viral culture for CMV were positive, and a brain CT revealed ventriculomegaly and periventricular calcification. And auditory evoked potential revealed left sensorineural hearing loss. He received ganciclovir treatment for 6 weeks, was discharged in good health, and continued conunder follow-up at the outpatient department.

Keyword

CMV infection; Hearing loss; Newborn

MeSH Terms

Anemia
Brain
Cytomegalovirus Infections*
Cytomegalovirus*
Evoked Potentials, Auditory
Exanthema
Fetal Growth Retardation
Follow-Up Studies
Ganciclovir
Hearing Loss
Hearing Loss, Sensorineural
Hearing*
Humans
Incidence
Infant, Newborn
Jaundice
Live Birth
Male
Microcephaly
Outpatients
Parturition
Polymerase Chain Reaction
Purpura
Thrombocytopenia
Ganciclovir