Korean J Perinatol.  2012 Dec;23(4):273-279.

Two Cases of Congenital Cytomegalovirus Infection with Pulmonary Hypertension

• Kim AY
• Kim YS
• Park KH
• Byun SY

Abstract

Cytomegalovirus (CMV) is the most common cause of intrauterine infection. 90% of congenital CMV infection being asymptomatic, only 5% of CMV infections are presented with severe symptoms: intrauterine growth retardation, petechia, hepatosplenomegaly, thrombocytopenia, hearing loss and mental retardation. We experienced two cases of symptomatic congenital CMV infection with persistent pulmonary hypertension in NICU who presented intrauterine growth retardation, petechia, cholestasis, hepatosplenomegaly, and thrombocytopenia. Persistent pulmonary hypertension improved after ventilator care, and hearing loss also improved after ganciclovir treatment for 6 weeks.

Keyword

Cytomegalovirus; Pulmonary hypertension

MeSH Terms

Cholestasis
Cytomegalovirus
Cytomegalovirus Infections
Fetal Growth Retardation
Ganciclovir
Hearing Loss
Hypertension, Pulmonary
Intellectual Disability
Thrombocytopenia
Ventilators, Mechanical
Ganciclovir