J Korean Acad Rehabil Med.  2000 Aug;24(4):624-630.

Serum Lipid Profile and Prognosis of Stroke Patient according to Genotype of Apolipoprotein E

• Kim YH
• Park SH
• Shin YI
• Seo JH
• Kim DS

Abstract

OBJECTIVE
To determine allele frequencies of apolipoprotein (Apo) E according to the type of stroke in Korean and to investigate the relationship between the Apo E genotype and serum lipid profile as well as outcome after stroke. METHOD: Fifty-eight stroke patients admitted between January and December 1999 were enrolled. The serum concentrations of total cholesterol, triglyceride, and HDL-cholesterol were measured. The LDL-cholesterol concentration were calculated by Friedwald formula. Apo E genotypes were determined by polymerase chain reaction (PCR) and polyacrylamide gel electrophoresis (PAGE). The outcome of stroke was measured by functional independence measure (FIM) scores.
RESULTS
Most frequent Apo E genotype was E 3/3 (72%), followed by E 3/4 (17%), E 2/3 (9%) and E 2/2 (2%). The level of total serum cholesterol and LDL-cholesterol were lower in the stroke patients who have (epsilon)2 allele in comparison with the patients without that allele. (epsilon)4 allele does not influence on the outcome of stroke patients measured by FIM.
CONCLUSION
Most frequent Apo E genotype was E3/3. (epsilon)2 allele influenced on the serum cholesterol level in stroke patients. However, (epsilon)4 allele does not correlate with worse prognosis in stroke patients in this study.

Keyword

Apolipoprotein E genotype; Stroke; FIM; Cholesterol; LDL-cholesterol

MeSH Terms

Alleles
Apolipoproteins E
Apolipoproteins*
Cholesterol
Electrophoresis, Polyacrylamide Gel
Gene Frequency
Genotype*
Humans
Polymerase Chain Reaction
Prognosis*
Stroke*
Triglycerides
Apolipoproteins
Apolipoproteins E
Cholesterol