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Vessel Wall Changes on Serial High-Resolution MRI and the Use of Cilostazol in Patients With Adult-Onset Moyamoya Disease

Kim JY, Kim HJ, Choi EH, Pan KH, Chung JW, Seo WK, Kim GM, Jee TK, Yeon JY, Kim JS, Hong SC, Seong MJ, Cha J, Kim KH, Jeon P, Bang OY

Background and Purpose The natural course of adult-onset moyamoya disease (MMD) is unknown, and there is no medical treatment that halts its progression. We hypothesized that progressive shrinkage of large...
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Percutaneous Patent Foramen Ovale Closure After Stroke

Lee OH, Kim JS

Percutaneous patent foramen ovale (PFO) closure in patients with a prior PFO-associated stroke showed a risk reduction of the stroke recurrence compared to the medical therapy alone in recent several...
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Neutrophil Recruitment in Arterial Thrombus and Characteristics of Stroke Patients with Neutrophil-Rich Thrombus

Cha MJ, Ha J, Lee H, Kwon I, Kim S, Kim YD, Nam HS, Lee HS, Song TJ, Choi HJ, Heo JH

Purpose: Neutrophils contribute to thrombosis. However, there is limited information on the temporal course of neutrophil recruitment in thrombosis, the contribution of neutrophils to thrombus growth, and the characteristics of...
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Mechanical Thrombectomy for Acute Ischemic Stroke due to Thrombus in the Pulmonary Vein Stump after Left Pulmonary Lobectomy: A Case Series

Tsuji Y, Yagi R, Hiramatsu R, Wanibuchi M

Cerebral embolic stroke caused by a thrombus in the pulmonary vein stump after left pulmonary lobectomy is a serious complication. We retrospectively analyzed four patients who underwent mechanical thrombectomy for...
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Mechanical Thrombectomy for Septic Embolism Secondary to Staphylococcus lugdunensis Bacteremia without Infective Endocarditis: A Case Report

Nguyen AVP, Daly SR, Liang B, Lesley WS

A cerebral large vessel occlusion due to septic embolism with resultant stroke is a known complication of infective endocarditis and can cause severe neurologic disability. However, septic embolism rarely occurs...
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National Trends in Medical Costs and Prognosis of Acute Ischemic Stroke Patients in Endovascular Thrombectomy Era: Analysis Using Medical Claim Data in Korea

Jung WS, Seo KD, Suh SH

Purpose: The purpose of this study was to evaluate trends in medical costs and prognosis in acute ischemic stroke (AIS) patients in Korea from 2008 to 2017 using medical claims...
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CADASIL with Intracerebral Hemorrhage after Acute Ischemic Stroke

Kim TY, Koo BG, Han MG, Shin DJ

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Hereditary Diffuse Leukoencephalopathy with Axonal Spheroids Mistaken for Stroke: A Case Report

Hwang S, Ha J, Choi MY, Jeong H, Cho EB, Yang TW, Park KJ, Jung S, Kim SJ

Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) is a rare autosomal dominant disorder that is caused by colony stimulating factor 1 receptor gene mutation degenerating the cerebral white matter. It...
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Factors in early hospital arrival following suspected acute stroke symptoms

Han DH, Shin J, Jung JH, Song KJ, Lee HJ, You KM

  • KMID: 2535902
  • J Korean Soc Emerg Med.
  • 2022 Oct;33(5):436-447.
Objective: We investigated the factors that affect the time from the onset of acute stroke symptoms to arrival at the emergency department (ED). Methods: Between July 2019 and February 2020, patients...
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Low-Frequency Repetitive Transcranial Magnetic Stimulation in the Early Subacute Phase of Stroke Enhances Angiogenic Mechanisms in Rats

Lee Y, Oh BM, Park SH, Han TR

Objective To characterize the repetitive transcranial magnetic stimulation (rTMS) induced changes in angiogenic mechanisms across different brain regions. Methods Seventy-nine adult male Sprague-Dawley rats were subjected to a middle cerebral artery...
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Distribution of Neuroglobin in Pericytes is Associated with Blood-Brain Barrier Leakage against Cerebral Ischemia in Mice

Kim Y, Kim M, Kim SD, Yoon N, Wang X, Bae GU, Song YS

  • KMID: 2535060
  • Exp Neurobiol.
  • 2022 Oct;31(5):289-298.
  • doi: 10.5607/en22001
With emerging data on the various functions of neuroglobin (Ngb), such as neuroprotection and neurogenesis, we investigated the role of Ngb in the neurovascular unit (NVU) of the brain. To...
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Comparison of Factors Associated With Direct Versus Transferred-in Admission to Government-Designated Regional Centers Between Acute Ischemic Stroke and Myocardial Infarction in Korea

Kim DH, Moon SJ, Lee J, Cha JK, Kim MH, Park JS, Ban B, Kang J, Kim BJ, Kim WS, Yoon CH, Lee H, Kim S, Kang EK, Her AY, Yoon CW, Rha JH, Woo SI, Lee WK, Jung HY, Lee JH, Park HS, Hwang YH, Kim K, Kim RB, Choi NC, Hwang J, Park HW, Park KS, Yi S, Cho JY, Kim NH, Choi KH, Kim J, Han JY, Choi JC, Kim SY, Choi JH, Kim J, Sohn MK, Choi SW, Shin DI, Lee SY, Bae JW, Lee KS, Bae HJ

Background: There has been no comparison of the determinants of admission route between acute ischemic stroke (AIS) and acute myocardial infarction (AMI). We examined whether factors associated with direct versus...
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Validation of Biomarker-Based ABCD Score in Atrial Fibrillation Patients with a Non-Gender CHA2DS2 -VASc Score 0–1: A Korean Multi-Center Cohort

Jung M, Byeon K, Kang KW, Park YM, Hwang YM, Lee SH, Jin ES, Roh SY, Kim JS, Ahn J, Lee SR, Choi EK, Ahn Ms, Lee EM, Park HC, Lee KH, Kim M, Choi JH, Ko JS, Kim JB, Kim C, Lip GY, Shin SY, Clinical Survey on Stroke Prevention in Patients with Atrial Fibrillation (CS-SPAF) Investigators

Purpose: Atrial fibrillation (AF) patients with low to intermediate risk, defined as non-gender CHA2DS2-VASc score of 0–1, are still at risk of stroke. This study verified the usefulness of ABCD...
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Adaptive Behavior in Stroke Survivors: A Concept Analysis

Choi H, Lim A, Song Y

Purpose: This study aims to explore a clear and evidence-based definition of adaptive behavior in stroke survivors and establish the antecedents, attributes, consequences, and empirical referents of the concept. Methods: The...
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Outcome Prediction in Cerebral Venous Thrombosis: The IN-REvASC Score

Klein P, Shu L, Nguyen TN, Siegler JE, Omran SS, Simpkins AN, Heldner M, Havenon Ad, Aparicio HJ, Abdalkader M, Psychogios M, Vedovati MC, Paciaroni M, Martial Rv, Liebeskind DS, Sousa DAd, Coutinho JM, Yaghi S, the ACTION-CVT Study Group

Background We identified risk factors, derived and validated a prognostic score for poor neurological outcome and death for use in cerebral venous thrombosis (CVT). Methods We performed an international multicenter...
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Mechanical Thrombectomy in Acute Stroke Patients with Moderate to Severe Pre-Stroke Disability

Sykora M, Michel P, Strambo D, Krebs S, Ferrari J, Posekany A, Mikšová D, Hermann K, Gattringer T, Gizewski E, Deutschmann H, Neumann C, Lang W

Background and Purpose Studies on mechanical thrombectomy (MT) in acute ischemic stroke (AIS) patients with preexisting disability are limited. We aimed to compare the outcomes of MT versus best medical...
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Simplified Assessment of Lesion Water Uptake for Identification of Patients within 4.5 Hours of Stroke Onset: An Analysis of the MissPerfeCT Study

Sporns PB, Höhne M, Meyer L, Krogias C, Puetz V, Thierfelder KM, Duering M, Kaiser D, Langner S, Brehm A, Rotkopf LT, Kunz WG, Fiehler J, Heindel W, Schramm P, Wiendl H, Minnerup H, Psychogios MN, Kemmling A, Minnerup J

Background and Purpose Many patients with stroke cannot receive intravenous thrombolysis because the time of symptom onset is unknown. We tested whether a simple method of computed tomography (CT)-based quantification...
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Venous Outflow Profiles Are Linked to Clinical Outcomes in Ischemic Stroke Patients with Extensive Baseline Infarct

Winkelmeier L, Broocks G, Kniep H, Geest V, Reinwald J, Meyer L, van Horn N, Guenego A, Zeleňák K, Albers GW, Lansberg M, Sporns P, Wintermark M, Fiehler J, Heit JJ, Faizy TD

Background and Purpose The benefit of endovascular thrombectomy (EVT) treatment is still unclear in stroke patients presenting with extensive baseline infarct. The use of additional imaging biomarkers could improve clinical...
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Establishment of the Heart and Brain Team for Patent Foramen Ovale Closure in Stroke Patients: An Expert Opinion

Kim JS, Thijs V, Yudi M, Toyoda K, Shiozawa M, Zening J, Clapp B, Albers B, Diener HC

The online 2021 Asian-Pacific Heart and Brain Summit was organized to present and discuss experiences within leading Asian-Pacific centers with regard to institutional heart and brain teams managing the diagnosis,...
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Transcatheter Patent Foramen Ovale Closure in Stroke Patients with Thrombophilia: Current Status and Future Perspectives

Farjat-Pasos JI, Nuche J, Mesnier J, Panagides V, Cloutier S, Houde C, Rodés-Cabau J

Transcatheter patent foramen ovale (PFO) closure is a safe and effective treatment for secondary prevention after a PFO-associated stroke as demonstrated in multiple large randomized clinical trials. However, these trials...
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