Psychiatry Investig.  2013 Mar;10(1):8-16.

Trends in Scientific Literature on Atypical Antipsychotics in South Korea: A Bibliometric Study

Affiliations
  • 1Faculty of Health Sciences, Camilo Jose Cela University, Madrid, Spain. francisco.lopez.munoz@gmail.com
  • 2Department of Pharmacology, University of Alcala, Madrid, Spain.
  • 3Department of Psychiatry, Wan Fang Medical Center and School of Medicine, Taipei Medical University, Taipei, Taiwan.
  • 4Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea.
  • 5Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC, USA.
  • 6Department of Psychiatry, "Doce de Octubre" University Hospital, Complutense University, Madrid, Spain.
  • 7Acute Inpatients Unit, Dr. R. Lafora Psychiatric Hospital, Madrid, Spain.

Abstract


OBJECTIVE
We have carried out a bibliometric study on the scientific publications in relation to atypical or second-generation antipsychotic drugs (SGAs) in South Korea.
METHODS
With the EMBASE and MEDLINE databases, we selected those publications made in South Korea whose title included the descriptors atypic* (atypical*) antipsychotic*, second-generation antipsychotic*, clozapine, risperidone, olanzapine, ziprasidone, quetiapine, sertindole, aripiprazole, paliperidone, amisulpride, zotepine, asenapine, iloperidone, lurasidone, perospirone and blonanserin. We applied some bibliometric indicators of paper production and dispersion with Price's law and Bradford's law, respectively. We also calculated the participation index (PI) of the different countries, and correlated the bibliometric data with some social and health data from Korea (such as total per capita expenditure on health and gross domestic expenditure on research and development).
RESULTS
We collected 326 original papers published between 1993 and 2011. Our results state fulfilment of fulfilled Price's law, with scientific production on SGAs showing exponential growth (correlation coefficient r=0.8978, as against an r=0.8149 after linear adjustment). The most widely studied drugs were risperidone (91 papers), aripiprazole (77), olanzapine (53), and clozapine (43). Division into Bradford zones yielded a nucleus occupied by the Progress in Neuro-Psychopharmacology and Biological Psychiatry (36 articles). A total of 86 different journals were published, with 4 of the first 10 used journals having an impact factor being greater than 4.
CONCLUSION
The publications on SGAs in South Korea have undergone exponential growth over the studied period, without evidence of reaching a saturation point.

Keyword

Second-generation antipsychotics; Atypical antipsychotics; Bibliometry; Schizophrenia; Bipolar disorder; South Korea

MeSH Terms

Antipsychotic Agents
Benzodiazepines
Biological Psychiatry
Bipolar Disorder
Clozapine
Complement Factor B
Dibenzothiazepines
Dibenzothiepins
Health Expenditures
Heterocyclic Compounds with 4 or More Rings
Imidazoles
Indoles
Isoindoles
Isoxazoles
Jurisprudence
Korea
Piperazines
Piperidines
Pyrimidines
Quinolones
Republic of Korea
Risperidone
Schizophrenia
Subject Headings
Sulpiride
Thiazoles
Quetiapine Fumarate
Aripiprazole
Lurasidone Hydrochloride
Antipsychotic Agents
Benzodiazepines
Clozapine
Complement Factor B
Dibenzothiazepines
Dibenzothiepins
Heterocyclic Compounds with 4 or More Rings
Imidazoles
Indoles
Isoindoles
Isoxazoles
Piperazines
Piperidines
Pyrimidines
Quinolones
Risperidone
Sulpiride
Thiazoles
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