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Clinical Efficacy and Safety of Naftopidil Treatment for Patients with Benign Prostatic Hyperplasia and Hypertension: A Prospective, Open-Label Study

Chung MS, Yoon BI, Lee SH

PURPOSE: To investigate the efficacy and safety of naftopidil for benign prostatic hyperplasia (BPH) patients, mainly focusing on changes in blood pressure (BP). MATERIALS AND METHODS: Of a total of 118...
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Elk-3 Contributes to the Progression of Liver Fibrosis by Regulating the Epithelial-Mesenchymal Transition

Li TZ, Kim SM, Hur W, Choi JE, Kim JH, Hong SW, Lee EB, Lee JH, Yoon SK

BACKGROUND/AIMS: The role of Elk-3 in the epithelial-mesenchymal transition (EMT) during liver fibrogenesis remains unclear. Here, we determined the expression of Elk-3 in in vitro and in vivo models and...
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Efficacy and Safety of Intravenous Urapidil for Older Hypertensive Patients with Acute Heart Failure: A Multicenter Randomized Controlled Trial

Yang W, Zhou YJ, Fu Y, Qin J, Qin S, Chen XM, Guo JC, Wang DZ, Zhan H, Li J, He JY, Hua Q

PURPOSE: Urapidil is putatively effective for patients with hypertension and acute heart failure, although randomized controlled trials thereon are lacking. We investigated the efficacy and safety of intravenous urapidil relative...
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Fluid Retention Associated with Imatinib Treatment in Patients with Gastrointestinal Stromal Tumor: Quantitative Radiologic Assessment and Implications for Management

Kim KW, Shinagare , Krajewski , Pyo J, Tirumani S, Jagannathan JP, Ramaiya NH

OBJECTIVE: We aimed to describe radiologic signs and time-course of imatinib-associated fluid retention (FR) in patients with gastrointestinal stromal tumor (GIST), and its implications for management. MATERIALS AND METHODS: In this...
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Rapid Sequential Gain of ABL1 Kinase Domain Mutations with a Complex Karyotype in the Progression of Chronic Myelogenous Leukemia

Chung Y, Eom HS, Lee H, Park S, Shim H, Cho EH, Kong SY

No abstract available.
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A Case of Isolated Lymphoblastic Relapse of the Central Nervous System in a Patient with Chronic Myelogenous Leukemia Treated with Imatinib

Park MJ, Park PW, Seo YH, Kim KH, Seo JY, Jeong JH, Kim MJ, Jeong JW, Ahn JY, Park J

No abstract available.
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Forensic Imaging for Causal Investigation of Death

Simons D, Sassenberg A, Schlemmer , Yen K

A 63-year-old man was found in the street after overrun by a car. Postmortem CT revealed multiple bone fractures, but surprisingly all without any relevant hemorrhage which would have been...
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Chronic myeloid leukemia as a secondary malignancy after diffuse large B-cell lymphoma

Lee HY, Lee KH, Hyun MS, Kim MK, Koh SA, Cho HS

No abstract available.
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Efficacy of imatinib mesylate-based front-line therapy in pediatric chronic myelogenous leukemia

Oh HJ, Cho MS, Lee JW, Jang PS, Chung NG, Cho B, Kim HK

PURPOSE: Despite the established role of imatinib (IM) in chronic myelogenous leukemia (CML) in adults, there are few reports on its efficacy in children. In this study, we compared the...
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A Case of Patient with Eisenmenger Syndrome Admitted to Intensive Care Unit Due to Septic Shock Complicated with Newlydiagnosed Down Syndrome and Moyamoya Disease

Lee SJ, Kang HW, Huh JW, Kim SW, Cho HW, Ryu YJ, Lee JH, Chang JH

Eisenmenger syndrome is a severe form of pulmonary arterial hypertension related to congenital cardiac defects. Many patients die at a young age from such complications. The treatment of primary pulmonary...
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The Prevalence of Metabolic Syndrome in Schizophrenic Patients Using Antipsychotics

Ko YK, Soh MA, Kang SH, Lee JI

  • KMID: 2171162
  • Clin Psychopharmacol Neurosci.
  • 2013 Aug;11(2):80-88.
OBJECTIVE: To examine the prevalence of metabolic syndrome and its risk factors in a large group of schizophrenic patients. METHODS: Sociodemographic and treatment data were collected from medical records of 1,103...
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Comparison of Aripiprazole and Other Atypical Antipsychotics for Pediatric Bipolar Disorder: A Retrospective Chart Review of Efficacy and Tolerability

Oh J, Chang JG, Lee SB, Song DH, Cheon KA

  • KMID: 2171160
  • Clin Psychopharmacol Neurosci.
  • 2013 Aug;11(2):72-79.
OBJECTIVE: This study compared the efficacy and tolerability of aripiprazole with that of other atypical antipsychotics by examining patients with pediatric bipolar disorder (PBD) at a child and adolescent psychiatric...
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Effect of Aripiprazole on Cognitive Function and Hyperprolactinemia in Patients with Schizophrenia Treated with Risperidone

Lee BJ, Lee SJ, Kim MK, Lee JG, Park SW, Kim GM, Kim YH

  • KMID: 2171156
  • Clin Psychopharmacol Neurosci.
  • 2013 Aug;11(2):60-66.
OBJECTIVE: This study aimed to assess the efficacy of aripiprazole for the management of cognitive impairments and hyperprolactinemia in patients with schizophrenia on a stable dose of risperidone. METHODS: Thirty-five subjects...
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Imatinib Plasma Monitoring-Guided Dose Modification for Managing Imatinib-Related Toxicities in Gastrointestinal Stromal Tumor Patients

Yoon S, Ryu MH, Yoo C, Beck MY, Ryoo BY, Kang YK

Imatinib, the first-line treatment in patients with advanced gastrointestinal stromal tumors (GIST), is generally well tolerated, although some patients have difficulty tolerating the standard dose of 400 mg/day. Adjusting imatinib...
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Systematic Review and Meta-Analysis of Pulmonary Hypertension Specific Therapy for Exercise Capacity in Chronic Obstructive Pulmonary Disease

Park J, Song JH, Park DA, Lee JS, Lee SD, Oh YM

Some patients with chronic obstructive pulmonary disease (COPD) have pulmonary hypertension (PH) that adversely affects survival. We performed a systematic review and meta-analysis to assess whether PH-specific therapies have an...
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New Oral Antiplatelet Agents

Kang MK, Chang K

  • KMID: 2267821
  • Korean J Med.
  • 2013 Jul;85(1):10-14.
Antiplatelet agents play an essential role in the treatment of acute coronary syndrome (ACS). Aspirin and thienopyridines comprise the major classes of antiplatelet therapies demonstrated to be of benefit in...
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Comparison of the Population Pharmacokinetics and Safety Between Please Orally Soluble Film and VIAGRA(R) in Healthy Male Volunteers

Hong T, Lee J, Jeon S, Paek J, Kim HI, Kwak SS, Park SJ, Han S, Yim DS

  • KMID: 2334542
  • J Korean Soc Clin Pharmacol Ther.
  • 2013 Jun;21(1):26-33.
BACKGROUND: The objective of this study was to compare the pharmacokinetics and safety between newly developed sildenafil (Please Orally Soluble Film) and sildenafil citrate (VIAGRA(R)) after single oral administration in...
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Two Cases of Hypersexuality Probably Associated with Aripiprazole

Cheon E, Koo BH, Seo SS, Lee JY

  • KMID: 2316269
  • Psychiatry Investig.
  • 2013 Jun;10(2):200-202.
Sexual dysfunction is a common side effect in patients treated with antipsychotics but significant differences exist across different compounds. We report hypersexuality symptoms in two female patients with schizophrenia who...
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Treatment of eggshell with casein phosphopeptide reduces the severity of ovariectomy-induced bone loss

Kim JH, Kim MS, Oh HG, Lee HY, Park JW, Lee BG, Park SH, Moon DI, Shin EH, Oh EK, Erkhembaatar M, Kim O, Lee YR, Chae HJ

It has been generally accepted that calcium intake prevents bone loss, and frequent fracture resulted from osteoporosis. However, it is still elusive as to how effective sole calcium intake is...
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Successful Prasugrel Rescue Therapy in Clopidogrel Resistant Patients Who Had Recurrent Stent Thrombosis of Drug-Eluting-Stent: The Role of Prasugrel in Clopidogrel Nonresponders

Lee SH, Kim BK, Oh J, Park JS, Lee DJ, Lee HC, Kim JH, Hong MK

Stent thrombosis is a very serious problem after drug-eluting stent (DES) implantation even though its incidence is about or less than 1%. As the clopidogrel resistance is expected to play...
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