Nutr Res Pract.  2013 Feb;7(1):43-48.

The association between measurement sites of visceral adipose tissue and cardiovascular risk factors after caloric restriction in obese Korean women

• Lee HO
• Yim JE
• Lee JS
• Kim YS
• Choue R

Abstract

Quantities as well as distributions of adipose tissue (AT) are significantly related to cardiovascular disease (CVD) risk factors and can be altered with caloric restriction. This study investigated which cross-sectional slice location of AT is most strongly correlated with changes in CVD risk factors after caloric restriction in obese Korean women. Thirty-three obese pre-menopausal Korean women (32.4 +/- 8.5 yrs, BMI 27.1 +/- 2.3 kg/m2) participated in a 12 weeks caloric restriction program. Subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) were measured using computed tomography (CT) scans at the sites of L2-L3, L3-L4, and L4-L5. Fasting serum levels of glucose, insulin, triglyceride, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), leptin and homeostasis model assessment-insulin resistance (HOMA-IR) were observed. Pearson's partial correlation coefficients were used to assess the relationship between AT measurement sites and changes in CVD risk factors after calorie restriction. When calories were reduced by 350 kcal/day for 12 weeks, body weight (-2.7%), body fat mass (-8.2%), and waist circumference (-5.8%) all decreased (P < 0.05). In addition, following caloric restriction, serum levels of glucose (-4.6%), TC (-6.2%), LDL-C (-5.3%), leptin (-17.6%) and HOMA-IR (-18.2%) decreased significantly (P < 0.05) as well. Changes in VAT at the level of L3-L4 were significantly greater than those at other abdominal sites, and these changes were correlated with changes in TC (P < 0.05), LDL-C (P < 0.001), SBP (P < 0.001) and HOMA-IR (P < 0.01). These results show that VAT at L3-L4 had a stronger correlation with CVD risk factors than with other AT measurement sites after caloric restriction.

Keyword

Caloric restriction; CT; measurement site; VAT; CVD risk factors

MeSH Terms

Adipose Tissue
Body Weight
Caloric Restriction
Cardiovascular Diseases
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Fasting
Female
Glucose
Homeostasis
Humans
Insulin
Intra-Abdominal Fat
Leptin
Lipoproteins
Risk Factors
Subcutaneous Fat
Waist Circumference
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Glucose
Insulin
Leptin
Lipoproteins