Int Neurourol J.
2016 May;20(Suppl 1):S57-S64.
Postnatal Treadmill Exercise Alleviates Prenatal Stress-Induced Anxiety in Offspring Rats by Enhancing Cell Proliferation Through 5-Hydroxytryptamine 1A Receptor Activation
- Affiliations
-
- 1Department of Physical Education, College of Health, Welfare, and Education, Tong Myong University, Busan, Korea.
- 2Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.
- 3Department of Medicine, Graduate School, Kyung Hee University, Seoul, Korea.
- 4Department of Food and Biotechnology, Graduate School of Life Sciences and Biotechnology, Korea University, Seoul, Korea.
- 5Department of Emergency Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea. chohj327@korea.ac.kr
Abstract
- PURPOSE
Stress during pregnancy is a risk factor for the development of anxiety-related disorders in offspring later in life. The effects of treadmill exercise on anxiety-like behaviors and hippocampal cell proliferation were investigated using rats exposed to prenatal stress.
METHODS
Exposure of pregnant rats to a hunting dog in an enclosed room was used to induce stress. Anxiety-like behaviors of offspring were evaluated using the elevated plus maze test. Immunohistochemistry for the detection of 5-bromo-2'-deoxyuridine and doublecortin (DCX) in the hippocampal dentate gyrus and 5-hydroxytryptamine 1A receptors (5-HT(1A)) in the dorsal raphe was conducted. Brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) levels in the hippocampus were evaluated by western blot analysis.
RESULTS
Offspring of maternal rats exposed to stress during pregnancy showed anxiety-like behaviors. Offspring also showed reduced expression of BDNF, TrkB, and DCX in the dentate gyrus, decreased cell proliferation in the hippocampus, and reduced 5-HT(1A) expression in the dorsal raphe. Postnatal treadmill exercise by offspring, but not maternal exercise during pregnancy, enhanced cell proliferation and expression of these proteins.
CONCLUSIONS
Postnatal treadmill exercise ameliorated anxiety-like behaviors in offspring of stressed pregnant rats, and the alleviating effect of exercise on these behaviors is hypothesized to result from enhancement of cell proliferation through 5-HT(1A) activation in offspring rats.
MeSH Terms
-
Animals
Anxiety*
Blotting, Western
Brain-Derived Neurotrophic Factor
Bromodeoxyuridine
Cell Proliferation*
Dentate Gyrus
Dogs
Dorsal Raphe Nucleus
Exercise Test
Hippocampus
Immunohistochemistry
Pregnancy
Prenatal Exposure Delayed Effects
Protein-Tyrosine Kinases
Rats*
Receptor, Serotonin, 5-HT1A*
Risk Factors
Serotonin*
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