Korean J Pediatr.
2018 May;61(5):150-155. 10.3345/kjp.2018.61.5.150.
Long-term prenatal stress increases susceptibility of N-methyl-D-aspartic acid-induced spasms in infant rats
- Affiliations
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- 1Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, Korea. childlove@cnu.ac.kr
- 2Department of Anatomy, College of Medicine, Chungnam National University, Daejeon, Korea.
- 3Department of Pediatrics, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.
- 4Brain Research Institute, College of Medicine, Chungnam National University, Daejeon, Korea.
- KMID: 2412141
- DOI: http://doi.org/10.3345/kjp.2018.61.5.150
Abstract
- PURPOSE
Infantile spasms, also known as West syndrome, is an age-specific epileptic seizure. Most patients with this condition also exhibit delayed development. This study aimed to determine the effect of long-term prenatal stress on susceptibility to infantile spasms.
METHODS
We subjected pregnant rats to acute or chronic immobilization stress. Resulting offspring received N-methyl-D-aspartic acid (15 mg/kg, intraperitoneally) on postnatal day 15, and their behaviors were observed 75 minutes after injection. The expression of KCC2 and GAD67 was also determined using immunohistochemistry.
RESULTS
Exposure to long-term prenatal stress increased the frequency of spasms and decreased the latency to onset of spasms compared with offspring exposed to short-term prenatal stress. Expression of KCC2 and GAD67 also decreased in the group exposed to long-term prenatal stress compared with the group exposed to short-term prenatal stress.
CONCLUSION
Our study suggests that exposure to long-term prenatal stress results in increased susceptibility to seizures.
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