- Luteolin attenuates migration and invasion of lung cancer cells via suppressing focal adhesion kinase and non-receptor tyrosine kinase signaling pathway
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Masraksa W, Tanasawet , Hutamekalin P, Wongtawatchai T, Sukketsiri W
- KMID: 2471880
- Nutr Res Pract.
- 2020 Apr;14(2):127-133.
- doi: 10.4162/nrp.2020.14.2.127
BACKGROUND/OBJECTIVES: Non-small cell lung cancer is mostly recognized among other types of lung cancer with a poor prognosis by cause of chemotherapeutic resistance and increased metastasis. Luteolin has been found... -
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- Genetic Characterization of Molecular Targets in Korean Patients with Gastrointestinal Stromal Tumors
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Park J, Yoo HM, Sul HJ, Shin S, Lee SW, Kim JG
- KMID: 2471923
- J Gastric Cancer.
- 2020 Mar;20(1):29-40.
- doi: 10.5230/jgc.2020.20.e2
PURPOSE: Gastrointestinal stromal tumors (GISTs) frequently harbor activating gene mutations in either KIT or platelet-derived growth factor receptor A (PDGFRA) and are highly responsive to several selective tyrosine kinase inhibitors.... -
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- Inhibitory Effect of Rosae Multiflorae Fructus Extracts on the Receptor Activator of NF-κB Ligand-Induced Osteoclastogenesis through Modulation of P38- and Ca2âº-Mediated Nuclear Factor of Activated T-Cells Cytoplasmic 1 Expression
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Park KH, Gu DR, Kim MS, Lee SH
- KMID: 2471314
- J Bone Metab.
- 2020 Feb;27(1):53-63.
- doi: 10.11005/jbm.2020.27.1.53
BACKGROUND: Rosae Multiflorae fructus (RMF), known to have anti-inflammatory and antioxidant properties, has been used as a traditional remedy for inflammatory diseases such as arthritis in Eastern Asia. However, its... -
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- Current Status and Future Direction of Immunotherapy in Hepatocellular Carcinoma: What Do the Data Suggest?
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Lee HW, Cho KJ, Park JY
- KMID: 2471051
- Immune Netw.
- 2020 Feb;20(1):e11.
- doi: 10.4110/in.2020.20.e11
Most patients with hepatocellular carcinoma (HCC) are diagnosed at an advanced stage of disease. Until recently, systemic treatment options that showed survival benefits in HCC have been limited to tyrosine... -
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- Immunotherapy for Non-small Cell Lung Cancer: Current Landscape and Future Perspectives
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Lim SM, Hong MH, Kim HR
- KMID: 2471050
- Immune Netw.
- 2020 Feb;20(1):e10.
- doi: 10.4110/in.2020.20.e10
Immune checkpoint inhibitors (ICIs) have shown remarkable benefit in the treatment of patients with non-small-cell lung cancer (NSCLC) and have emerged as an effective treatment option even in the first-line... -
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- Involvement of the TNF-α Pathway in TKI Resistance and Suggestion of TNFR1 as a Predictive Biomarker for TKI Responsiveness in Clear Cell Renal Cell Carcinoma
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Hwang HS, Park YY, Shin SJ, Go H, Park JM, Yoon SY, Lee JL, Cho YM
- KMID: 2469348
- J Korean Med Sci.
- 2020 Feb;35(5):e31.
- doi: 10.3346/jkms.2020.35.e31
BACKGROUND: Mechanism and predictive biomarkers for tyrosine kinase inhibitor (TKI) resistance of advanced clear cell renal cell carcinoma (ccRCC) have not been fully evaluated. METHODS: We performed gene expression profiling on... -
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- Current Status of Immunotherapy for Lung Cancer and Future Perspectives
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Kim HC, Choi CM
- KMID: 2466616
- Tuberc Respir Dis.
- 2020 Jan;83(1):14-19.
- doi: 10.4046/trd.2019.0039
Lung cancer remains the most common cause of cancer-related deaths worldwide. Although there are many possible treatments, including targeted therapies such as epidermal growth factor receptor tyrosine kinase inhibitors and... -
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- Reviews on the Hepatotoxicity of Tyrosine Kinase Inhibitors
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Han JM, Gwak HS
- KMID: 2470459
- Korean J Clin Pharm.
- 2019 Dec;29(4):223-230.
- doi: 10.24304/kjcp.2019.29.4.223
BACKGROUND: Small-molecule tyrosine kinase inhibitors (TKIs) have had major impacts on anticancer therapy by targeting the catalytic activities of dysregulated tyrosine kinases. TKIs have not presented traditional toxicities; however, some... -
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- Prognostic Significance of Systemic Inflammatory Response in Patients with Synchronous and Metachronous Metastatic Renal Cell Carcinoma Receiving First-Line Tyrosine Kinase Inhibitors
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Choi J, Kim TJ, Sung HH, Jeon HG, Jeong BC, Jeon SS, Lee HM, Choi HY, Kang M, Seo SI
- KMID: 2470400
- Korean J Urol Oncol.
- 2019 Dec;17(3):150-159.
- doi: 10.22465/kjuo.2019.17.3.150
PURPOSE: To determine whether systemic inflammatory response (SIR), particularly platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR), has different prognostic role between patients with metastatic renal cell carcinoma (mRCC) receiving first-line... -
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- Overcoming the Intrinsic Gefitinib-resistance via Downregulation of AXL in Non-small Cell Lung Cancer
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Jeong I, Song J, Bae SY, Lee SK
- KMID: 2468811
- J Cancer Prev.
- 2019 Dec;24(4):217-223.
- doi: 10.15430/JCP.2019.24.4.217
BACKGROUND: Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, is a limited factor in the treatment of non-small-cell lung cancer (NSCLC) patients. Therefore, ongoing studies... -
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- Anti-cancer Activity of Paclitaxel, Lenvatinib and Radiation Combination Therapy on Anaplastic Thyroid Cancer in Vitro and in Vivo
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Jun S, Kim SY, Kim SM, Park KC, Kim HJ, Chang HJ, Lee YS, Chang HS, Park CS
- KMID: 2469230
- Korean J Head Neck Oncol.
- 2019 Nov;35(2):19-25.
- doi: 10.21593/kjhno/2019.35.2.19
BACKGROUND/OBJECTIVES: Although anaplastic thyroid carcinoma (ATC) is rare, it is one of the deadliest forms of thyroid cancer. The fatality rate for ATC is high, and the survival rate at... -
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- A Case of Severe Pneumocystis Pneumonia in a Thyroid Cancer Patient Receiving Lenvatinib
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Jin MH, Kim WG, Kim TY, Kim WB, Shong YK, Jeon MJ
- KMID: 2465066
- Int J Thyroidol.
- 2019 Nov;12(2):127-131.
- doi: 10.11106/ijt.2019.12.2.127
Lenvatinib is a multitargeted tyrosine kinase inhibitor approved for use in patients with iodine-131–refractory thyroid cancer. The common adverse events of lenvatinib include hypertension, proteinuria, fatigue, and diarrhea. To date,... -
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- Mouse Nerve Growth Factor Facilitates the Growth of Interspinal Schwannoma Cells by Activating NGF Receptors
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Liu SY, Liu SZ, Li Y, Chen S
- KMID: 2463654
- J Korean Neurosurg Soc.
- 2019 Nov;62(6):626-634.
- doi: 10.3340/jkns.2019.0081
OBJECTIVE: Nerve growth factor (NGF) is a member of the neurotrophic factor family and plays a vital role in the physiological processes of organisms, especially in the nervous system. Many... -
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- RE-ORGA, a Korean Herb Extract, Can Prevent Hair Loss Induced by Dihydrotestosterone in Human Dermal Papilla Cells
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Kang MG, Park D, Han HY, Shim H, Hong Y, Moon J, Yoon S, Kwon B
- KMID: 2456230
- Ann Dermatol.
- 2019 Oct;31(5):530-537.
- doi: 10.5021/ad.2019.31.5.530
BACKGROUND: Androgenic alopecia (AGA) is the most common type of hair loss. It is likely inherited genetically and is promoted by dihydrotestosterone. 5α-reductase has been proven a good target through... -
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- Current Development and Research Trend of Chemotherapeutic Agents for Head and Neck Squamous Cell Carcinoma
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Lee YS
- KMID: 2461000
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2019 Sep;62(9):487-498.
- doi: 10.3342/kjorl-hns.2019.00479
After FDA approval of cetuximab at 2006, receptor tyrosine kinase, including an epidermal growth factor receptor, blocking agents have been evaluated for head and neck squamous cell carcinoma (HNSCC). Agents... -
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- Favorable long-term survival using consolidation chemotherapy without allogeneic hematopoietic cell transplantation for acute myeloid leukemia with wild-type NPM1 without FLT3-ITD
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Baek DW, Lee JM, Kim JH, Cho HJ, Ham JY, Suh JS, Sohn SK, Moon JH
- KMID: 2459384
- Blood Res.
- 2019 Sep;54(3):189-197.
- doi: 10.5045/br.2019.54.3.189
BACKGROUND: The role of allogeneic hematopoietic cell transplantation (allo-HCT) compared with consolidation chemotherapy alone in intermediate-risk acute myeloid leukemia (AML) patients with wild-type nucleophosmin/negative or a low level of Fms... -
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- Contrast Enhanced Endoscopic Ultrasound Imaging for Gastrointestinal Subepithelial Tumors
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Tamura T, Kitano M
- KMID: 2455625
- Clin Endosc.
- 2019 Jul;52(4):306-313.
- doi: 10.5946/ce.2019.056
Subepithelial tumors are divided into benign subepithelial and potentially malignant gastrointestinal stromal tumors. It is difficult to distinguish between these tumor types. Contrast-enhanced harmonic endoscopic ultrasound is reportedly useful for... -
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- Acquired Resistance of MET-Amplified Non-small Cell Lung Cancer Cells to the MET Inhibitor Capmatinib
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Kim S, Kim TM, Kim DW, Kim S, Kim M, Ahn YO, Keam B, Heo DS
- KMID: 2454287
- Cancer Res Treat.
- 2019 Jul;51(3):951-962.
- doi: 10.4143/crt.2018.052
PURPOSE: Amplified mesenchymal-epithelial transition factor, MET, is a receptor tyrosine kinase (RTK) that has been considered a druggable target in non-small cell lung cancer (NSCLC). Although multiple MET tyrosine kinase... -
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- Chemotherapy for Lung Cancer in the Era of Personalized Medicine
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Lee SH
- KMID: 2450894
- Tuberc Respir Dis.
- 2019 Jul;82(3):179-189.
- doi: 10.4046/trd.2018.0068
Although recent advances in molecular targeted therapy and immuno-oncology have revolutionized the landscape of lung cancer therapeutics, cytotoxic chemotherapy remains an essential component of lung cancer treatment. Extensive evidence has... -
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- Depigmentation in a Patient with Chronic Myeloid Leukemia during Chemotherapy with Dasatinib
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Choi YW, Na N, Park J
- KMID: 2451599
- Korean J Dermatol.
- 2019 Jun;57(5):292-293.
No abstract available. -
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