Clinical Features of Gallbladder Polyps Diagnosed by Histology

Shim, Sang Goon; Lee, Kyu Taek; Lee, Jong Kyun; Lee, Suk Ho; Ryu, Kwang Hyun; Lee, Joon Hyeok; Choi, Yoon Ho; Rhee, Poong Lyul; Kim, Jae Jun; Koh, Kwang Cheol; Paik, Seung Woon; Rhee, Jong Chul; Choi, Kyoo Wan; Noh, Jae Hyung; Choi, Seong Ho; Kim, Yong Il; Son, Hee Jung

Abstract

BACKGROUND/AIMS: We aimed to clarify clinical factors which suggest the possibility of neoplastic polyps of gallbladder.
METHODS
Ninety-five resected gallbladders with polyps were included. Size and number of the polyps were obtained by preoperative ultrasonography. Histollogically, the polyps were classified into non-neoplastic (cholesterol and inflammatory or hyperplastic polyp) and neoplastic lesions (adenoma and adenocarcinoma). Clinical features, maximum diameter and number of the polyps were compared between the two groups.
RESULTS
Of 95 patients, non-neoplastic polyps were observed in 65.3% and neoplastic polyps were observed in 34.7%. We found cholesterol polyp in 47.4%, inflammatory or hyperplastic polyp in 17.9%, adenoma in 25.2% and adenocarcinoma in 9.5%. Two groups showed no difference in age, sex, body mass index, cholesterol, triglyceride, glucose, ALT, HBsAg carriage and the number of polyps. Among the patients with non-neoplastic polyps, 70.2% was under 60 years, while 72.7% of the patients with neoplastic polyps was over 60 years (p<0.05). The size of polyps was under 10 mm in 88.9% of non-neoplastic polyps, and between 10 and 15 mm in 40% of neoplastic leisions. Moreover, 68.4% of neoplastic polyps exceeds 15 mm in diameter (p<0.05).
CONCLUSIONS
The size of polyp (> or =10 mm) and patient's age (> or =60 years) could be indicators for neoplastic polyps.