- Clinical Outcomes and Validation of Ursodeoxycholic Acid Response Scores in Patients with Korean Primary Biliary Cholangitis: A Multicenter Cohort Study
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Chang JI, Kim JH, Sinn DH, Cho JY, Kim KM, Oh JH, Park Y, Sohn W, Goh MJ, Kang W, Gwak GY, Paik YH, Choi MS, Lee JH, Koh KC, Paik SW
- KMID: 2544904
- Gut Liver.
- 2023 Jul;17(4):620-628.
- doi: 10.5009/gnl220420
Background/Aims: The ursodeoxycholic acid (UDCA) response score (URS) was developed to identify poor responders to UDCA before treatment, in order to offer timely and proactive intervention. However, validation of the... -
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- Changes in the prevalence of hepatitis B and metabolic abnormalities among young men in Korea
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Song BG, Sinn DH, Kang W, Gwak GY, Paik YH, Choi MS, Lee JH, Koh KC, Paik SW
- KMID: 2533150
- Korean J Intern Med.
- 2022 Sep;37(5):1082-1087.
- doi: 10.3904/kjim.2021.452
Changes in the prevalence of disease over time provide valuable information from a public health perspective. We used data from Korea Military Manpower Administration medical examinations for conscription between 2003... -
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- Outcome of patients with severe alcoholic hepatitis after Model for End-Stage Liver Disease-based allocation system implementation in Korea
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Kwon TJ, Kang W, Gwak GY, Paik YH, Choi MS, Lee JH, Koh KC, Sinn DH, Paik SW
- KMID: 2514405
- Korean J Transplant.
- 2021 Mar;35(1):24-32.
- doi: 10.4285/kjt.20.0054
Background: The Model for End-Stage Liver Disease (MELD)-based allocation system was implemented in Korea in July 2016 without a mandatory abstinence period for liver transplantation (LT) listing. However, the impact... -
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- Prognostic Value of Alpha-Fetoprotein in Patients Who Achieve a Complete Response to Transarterial Chemoembolization for Hepatocellular Carcinoma
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Lee JS, Chon YE, Kim BK, Park JY, Kim DY, Ahn SH, Han KH, Kang W, Choi MS, Gwak GY, Paik YH, Lee JH, Koh KC, Paik SW, Kim HY, Kim TH, Yoo K, Ha Y, Kim MN, Lee JH, Hwang SG, Kim SS, Cho HJ, Cheong JY, Cho SW, Park SH, Heo NY, Hong YM, Yoon KT, Cho M, Park JG, Kang MK, Park SY, Kweon YO, Tak WY, Jang SY, Sinn DH, Kim SU, The Korean TACE Study Group
- KMID: 2509849
- Yonsei Med J.
- 2021 Jan;62(1):12-20.
- doi: 10.3349/ymj.2021.62.1.12
Purpose: Alpha-fetoprotein (AFP) is a prognostic marker for hepatocellular carcinoma (HCC). We investigated the prognostic value of AFP levels in patients who achieved complete response (CR) to transarterial chemoembolization (TACE)... -
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- Comparison of outcome between liver resection, radiofrequency ablation, and transarterial therapy for multiple small hepatocellular carcinoma within the Milan criteria
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Oh JH, Sinn DH, Choi GS, Kim JM, Joh JW, Kang TW, Hyun D, Kang W, Gwak GY, Paik YH, Lee JH, Koh KC, Paik SW, Choi MS
- KMID: 2506655
- Ann Surg Treat Res.
- 2020 Oct;99(4):238-246.
- doi: 10.4174/astr.2020.99.4.238
Purpose: Although surgical resection is usually considered for a single tumor, several reports have suggested that resection can be considered for multiple tumors. The objective of this study was to... -
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- Substantial risk of recurrence even after 5 recurrence-free years in early-stage hepatocellular carcinoma patients
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Kim J, Kang W, Sinn DH, Gwak GY, Paik YH, Choi MS, Lee JH, Koh KC, Paik SW
- KMID: 2507971
- Clin Mol Hepatol.
- 2020 Oct;26(4):516-528.
- doi: 10.3350/cmh.2020.0016
Background/Aims: Although hepatocellular carcinoma (HCC) is notorious for its high recurrence rate, some patients do not experience recurrence for more than 5 years after resection or radiofrequency ablation for early-stage... -
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- Advanced Stage Hepatocellular Carcinoma Successfully Treated with Transarterial Radioembolization and Multi-tyrosine Kinase Inhibitor Therapy
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Goh MJ, Kang W, Sinn DH, Gwak GY, Paik YH, Choi MS, Lee JH, Koh KC, Paik SW
- KMID: 2508028
- J Liver Cancer.
- 2020 Sep;20(2):160-166.
- doi: 10.17998/jlc.20.2.160
Transarterial radioembolization (TARE) with yttrium-90 microspheres has become widely utilized in managing hepatocellular carcinoma (HCC). The utility of TARE is expanding with new insights through experiences from real-world practice and... -
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- Potential etiology, prevalence of cirrhosis, and mode of detection among patients with non-B non-C hepatocellular carcinoma in Korea
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Kim J, Kang W, Sinn DH, Gwak GY, Paik YH, Choi MS, Lee JH, Koh KC, Paik SW
- KMID: 2501988
- Korean J Intern Med.
- 2020 Jan;35(1):65-78.
- doi: 10.3904/kjim.2018.040
Background/Aims: We systematically evaluated the clinical characteristics, prevalence of cirrhosis, and mode of detection in virus-unrelated (non-B non-C, NBNC) hepatocellular carcinoma (HCC) patients in Korea. Methods: A total of 447 consecutive... -
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- Radiation-induced Myositis after Proton Beam Therapy to Huge Hepatocellular Carcinoma
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Kim J, Yoo GS, Sinn DH, Park HC, Koh KC
- KMID: 2463614
- J Liver Cancer.
- 2019 Sep;19(2):136-142.
- doi: 10.17998/jlc.19.2.136
Proton beam therapy (PBT) is one of the advances in radiotherapy techniques, which enables dose escalation with lower probability of radiation-induced liver or gastrointestinal injuries. However, the chest wall proximal... -
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- Impact of technical innovation on surgical outcome of laparoscopic major liver resection: 10 years' experience at a large-volume center
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Cho W, Kwon CH, Choi JY, Lee SH, Kim JM, Choi GS, Joh JW, Kim SJ, Kim GS, Koh KC
- KMID: 2429749
- Ann Surg Treat Res.
- 2019 Jan;96(1):14-18.
- doi: 10.4174/astr.2019.96.1.14
PURPOSE: Laparoscopic major liver resection (major LLR) remains a challenging procedure because of the technical difficulty. Several significant technical innovations have been applied in our center since 2012. They include... -
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- Initial clinical outcomes of proton beam radiotherapy for hepatocellular carcinoma
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Yu JI, Yoo GS, Cho S, Jung SH, Han Y, Park S, Lee B, Kang W, Sinn DH, Paik YH, Gwak GY, Choi MS, Lee JH, Koh KC, Paik SW, Park HC
- KMID: 2418882
- Radiat Oncol J.
- 2018 Mar;36(1):25-34.
- doi: 10.3857/roj.2017.00409
PURPOSE: This study aimed to evaluate the initial outcomes of proton beam therapy (PBT) for hepatocellular carcinoma (HCC) in terms of tumor response and safety. MATERIALS AND METHODS: HCC patients who... -
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- Noninvasive Diagnostic Criteria of the Revised 2014 the Korean Liver Cancer Study Group and the National Cancer Center Guideline for Subcentimetersized Hepatocellular Carcinoma: Is It Too Strict?
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Kim NJ, Sinn DH, Kang W, Paik YH, Choi MS, Lee JH, Koh KC, Paik SW, Gwak GY
- KMID: 2409647
- J Liver Cancer.
- 2018 Mar;18(1):44-50.
- doi: 10.17998/jlc.18.1.44
BACKGROUND/AIMS: Noninvasive diagnostic criteria for hepatocellular carcinoma (HCC) differ between guidelines, especially for subcentimeter-sized nodules. This study aimed to analyze clinical and radiological characteristics of subcentimeter-sized HCC, and assess the... -
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- A Novel Model for Predicting Hepatocellular Carcinoma Development in Patients with Chronic Hepatitis B and Normal Alanine Aminotransferase Levels
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Sinn DH, Lee JH, Kim K, Ahn JH, Lee JH, Kim JH, Lee DH, Yoon JH, Kang W, Gwak GY, Paik YH, Choi MS, Lee JH, Koh KC, Paik SW
- KMID: 2412233
- Gut Liver.
- 2017 Jul;11(4):528-534.
- doi: 10.5009/gnl16403
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) can develop in chronic hepatitis B (CHB) patients with normal alanine aminotransferase (ALT) levels. Therefore, methods that can stratify an individual's HCC risk are needed. METHODS: A... -
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- Long-term real-world entecavir therapy in treatment-naïve hepatitis B patients: base-line hepatitis B virus DNA and hepatitis B surface antigen levels predict virologic response
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Cho JY, Sohn W, Sinn DH, Gwak GY, Paik YH, Choi MS, Koh KC, Paik SW, Yoo BC, Lee JH
- KMID: 2387709
- Korean J Intern Med.
- 2017 Jul;32(4):636-646.
- doi: 10.3904/kjim.2016.096
BACKGROUND/AIMS: Entecavir is a potent nucleoside analogue with high efficacy and barrier for resistance. We aimed to investigate the long-term efficacy and viral resistance rate of entecavir and explore the... -
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- The Clinical Significance of Serum Alpha-fetoprotein in Diagnosing Hepatocellular Carcinoma in a Health Screening Population
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Ko YS, Bae JH, Sinn DH, Gwak GY, Kang W, Paik YH, Choi MS, Lee JH, Koh KC, Paik SW
- KMID: 2383401
- Korean J Gastroenterol.
- 2017 Apr;69(4):232-238.
- doi: 10.4166/kjg.2017.69.4.232
BACKGROUND/AIMS: Serum alpha-fetoprotein (AFP) measurement is commonly included in a health check-up program in Korea. However, its benefits remain uncertain. We analyzed whether AFP measurement should be included in a... -
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- The role of scheduled second TACE in early-stage hepatocellular carcinoma with complete response to initial TACE
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Kim JH, Sinn DH, Shin SW, Cho SK, Kang W, Gwak GY, Paik YH, Lee JH, Koh KC, Paik SW, Choi MS
- KMID: 2412113
- Clin Mol Hepatol.
- 2017 Mar;23(1):42-50.
- doi: 10.3350/cmh.2016.0058
BACKGROUND/AIMS: We investigated the outcomes of early-stage hepatocellular carcinoma (HCC) patients who showed a complete response (CR) to initial transarterial chemoembolization (TACE), with a focus on the role of scheduled... -
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- Clinical significance and predictive factors of early massive recurrence after radiofrequency ablation in patients with a single small hepatocellular carcinoma
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Cho JY, Choi MS, Lee GS, Sohn W, Ahn J, Sinn DH, Gwak GY, Paik YH, Lee JH, Koh KC, Paik SW
- KMID: 2373152
- Clin Mol Hepatol.
- 2016 Dec;22(4):477-486.
- doi: 10.3350/cmh.2016.0048
BACKGROUND/AIMS: Radiofrequency ablation (RFA) is one of the most frequently applied curative treatments in patients with a single small hepatocellular carcinoma (HCC). However, the clinical significance of and risk factors... -
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- Lamivudine versus Entecavir for Newly Diagnosed Hepatitis B Virus-Related Hepatocellular Carcinoma
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Kim JH, Sinn DH, Kim K, Kim H, Gwak GY, Paik YH, Choi MS, Lee JH, Koh KC, Paik SW
- KMID: 2412100
- Gut Liver.
- 2016 Nov;10(6):939-947.
- doi: 10.5009/gnl15527
BACKGROUND/AIMS: Antiviral therapy is a key component in the management of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients. However, whether the potent drug entecavir is more effective than a... -
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- Prediction of the Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Patients after Sustained Virological Response by Aspartate Aminotransferase to Platelet Ratio Index
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Lee K, Sinn DH, Gwak GY, Cho HC, Jung SH, Paik YH, Choi MS, Lee JH, Koh KC, Paik SW
- KMID: 2412078
- Gut Liver.
- 2016 Sep;10(5):796-802.
- doi: 10.5009/gnl15368
BACKGROUND/AIMS: Following sustained virological response (SVR) for chronic hepatitis C (CHC) infection, patients with advanced fibrosis require regular monitoring for hepatocellular carcinoma (HCC). The aspartate aminotransferase to platelet ratio index... -
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- Cause of Mortality for Hepatocellular Carcinoma Patients who were Diagnosed within the Milan Criteria
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Lee HW, Sinn DH, Kang W, Gwak GY, Paik YH, Choi MS, Lee JH, Koh KC, Paik SW
- KMID: 2357339
- J Liver Cancer.
- 2016 Sep;16(2):101-107.
- doi: 10.17998/jlc.2016.16.2.101
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is a unique condition where the cause of death might not only be due to progressive cancer, but also from liver failure. We evaluated specific causes... -
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