The Dose-response Relationship between Amount of Cigarette Smoking and Blood Lipids and Sugar

Lee, Kang Sook; Hong, Hyun Sook; Jeong, Jin Sook

Abstract

PURPOSE: To explore the dose-response relationship between amount of cigarette smoking and blood lipids and sugar METHODS: In this cross-sectional study, we gathered the smoking history by self-administered questionnaire between 1994 and 1998 among 2888 men who visited the Health Promotion Center at St. Mary's Hospital, Seoul. RESULTS: Adjusted for age, body mass index, the odds ratio of hypercholesterolemia (> or =240 mg/dl) were 2.06 (95% Confident Interval, 1.44-2.94), 2.03(95% CI 1.31-3.11), higher LDL-cholesterol(> or =160 mg/dl) were 2.06(95% CI 1.43-2.98), 2.25(95% CI 1.45-3.45) among group of men who smoked 21-30, over 30 cigarettes per day respectively compared with nonsmokers group. And adjusted for age, body mass index, the odds ratio of lower HDL-cholesterol(<35 mg/dl) were 1.76(95% CI 1.34-2.33), 1.98(95% CI 1.39-2.81), 2.35(95% CI 1.54-3.54), hypertriglyceridemia(> or =200 mg/dl) were 1.93(95% CI 1.47-2.55), 2.57(95% CI 1.82-3.62), 2.80(95% CI 1.86-4.21) among group of men who smoked 11-20, 21-30, over 30 cigarettes per day respectively compared with nonsmokers group. The adjusted odds ratio of diabetes(FBS> or =126 mg/dl) was 1.86(95% CI 1.10-3.06) only among who smoked more than 30 cigarettes compared with nonsmokers. CONCLUSION: This study showed that there were dose-response relationships betwen amount of cigarette smoking and total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride and sugar. It suggested that health promotion program including quitting and decrease of cigarette smoking would be necessary to prevent cardiovascular disease in Korean men.