Korean J Dermatol.
2000 Jul;38(7):966-968.
A Case of Cytomegalovirus Induced Purpura in a Bone Marrow Transplant Recipient
- Affiliations
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- 1Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
Abstract
- Cytomegalovirus(CMV) infection is very common in organ transplant recipients and other conditions such as lymphoproliferative disorders or acquired immunodeficiency syndrome. However, CMV rarely causes skin manifestations. We describe a leukemic patient with CMV induced purpuras which developed during cyclosporin therapy after a bone marrow transplantation. A biopsy revealed several foci of large irregular-shaped endothelial cells with large, basophilic intranuclear inclusions in the papillary dermis. Laboratory examination disclosed positive blood culture for CMV and polymerase chain reaction study performed with the skin sample revealed positive CMV DNA. Early intravenous gancyclovir made improvement of the skin lesions and negative conversion of viral antigenemia.
Keyword
MeSH Terms
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Acquired Immunodeficiency Syndrome
Basophils
Biopsy
Bone Marrow Transplantation
Bone Marrow*
Cyclosporine
Cytomegalovirus*
Dermis
DNA
Endothelial Cells
Ganciclovir
Humans
Intranuclear Inclusion Bodies
Lymphoproliferative Disorders
Polymerase Chain Reaction
Purpura*
Skin
Skin Manifestations
Transplantation*
Transplants
Cyclosporine
DNA
Ganciclovir
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