Korean Circ J.  2004 Aug;34(8):761-766. 10.4070/kcj.2004.34.8.761.

Association of Prostacyclin Synthase Gene C1117A Polymorphism with Acute Coronary Syndrome in Koreans

• Kim JH
• Jeong JO
• Choi SW
• Seong IW

• KMID: 2297980
• DOI: http://doi.org/10.4070/kcj.2004.34.8.761

Abstract

BACKGROUND AND OBJECTIVES
Platelets play an important role in the pathogenesis of acute coronary syndrome. Prostacyclin inhibits platelet aggregation, smooth muscle cell proliferation and vasoconstriction, and it counteracts thromboxane A2 activity. The purpose of this study is to evaluate the association between a single nucleotide polymorphism in the prostacyclin synthase gene and myocardial infarction in Koreans.
SUBJECTS AND METHODS
We studied total 119 patients (M: F=72: 47, mean ages=57.9). We compared 60 acute coronary syndrome patients who underwent coronary angiography with the diagnosis of acute myocardial infarction (MI), with 59 normal control group patients who had normal coronary angiograms. With the use of polymerase chain reaction-restriction fragment length polymorphism analysis, we identified a single nucleotide polymorphism, C1117A, in exon 8.
RESULTS
The genotype distribution and allele frequencies were significantly different between the control group and MI group. Frequency of the genotype C1117A was: AA: AC: CC=3.4%: 30.5%: 66.1% in control group, respectively, and AA: AC: CC=1.7%: 10.0%: 88.3% in MI group, respectively. Prostacyclin synthase polymorphism was observed in the MI group and the control group, but the frequency of the CC genotype was high in MI group (odds ratio, 3.88; 95% CI 1.49-10.88, p=0.003). Compared to control group, being male, having diabetes, hypertension or obesity, and the smoking rate were high in MI group. There were not significantly differences between genotypes for clinical characteristics.
CONCLUSION
We conclude that the C1117A polymorphism in exon 8 of the prostacyclin synthase gene is associated with MI, and it may be a genetic marker of MI in Koreans.

Keyword

Prostacyclin synthase; Polymorphism; Myocardial infarction

MeSH Terms

Acute Coronary Syndrome*
Coronary Angiography
Diagnosis
Epoprostenol*
Exons
Gene Frequency
Genetic Markers
Genotype
Humans
Hypertension
Male
Myocardial Infarction
Myocytes, Smooth Muscle
Obesity
Platelet Aggregation
Polymorphism, Single Nucleotide
Smoke
Smoking
Thromboxane A2
Vasoconstriction
Epoprostenol
Genetic Markers
Smoke
Thromboxane A2