- Decreased inward rectifier and voltage-gated K⺠currents of the right septal coronary artery smooth muscle cells in pulmonary arterial hypertensive rats
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Kim SE, Yin MZ, Kim HJ, Vorn R, Yoo HY, Kim SJ
- KMID: 2466575
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):111-119.
- doi: 10.4196/kjpp.2020.24.1.111
In vascular smooth muscle, K⺠channels, such as voltage-gated K⺠channels (Kv), inward-rectifier K⺠channels (Kir), and big-conductance Ca²âº-activated K⺠channels (BK(Ca)), establish a hyperpolarized membrane potential and counterbalance the... -
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- Analysis of interaction between intracellular spermine and transient receptor potential canonical 4 channel: multiple candidate sites of negatively charged amino acids for the inward rectification of transient receptor potential canonical 4
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Kim J, Moon SH, Kim T, Ko J, Jeon YK, Shin YC, Jeon JH, So I
- KMID: 2466574
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):101-110.
- doi: 10.4196/kjpp.2020.24.1.101
Transient receptor potential canonical 4 (TRPC4) channel is a nonselective calcium-permeable cation channels. In intestinal smooth muscle cells, TRPC4 currents contribute more than 80% to muscarinic cationic current (mIcat). With... -
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- Involvement of immune responses in pulmonary arterial hypertension; lessons from rodent models
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Kim K, Choi JH
- KMID: 2470011
- Lab Anim Res.
- 2019 Dec;35(4):148-153.
- doi: 10.1186/s42826-019-0021-1
Pulmonary hypertension (PH) is a pathological state with sustained elevation of pulmonary artery (PA) pressure. Since the pathogenesis of PH is mostly irreversible, the disease often comes up with poor... -
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- Development of Artificial Substitutes for Upper Digestive Tract: Personal Experience of Trials and Errors
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Chung EJ
- KMID: 2469951
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2019 Dec;62(12):675-680.
- doi: 10.3342/kjorl-hns.2019.00710
The current treatments for esophageal diseases, such as carcinomas, trauma or congenital malformations, require surgical intervention, and esophageal reconstruction using redundant parts of the gastrointestinal tract. However, the use of... -
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- Overview of Urethral Reconstruction by Tissue Engineering: Current Strategies, Clinical Status and Future Direction
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Rashidbenam Z, Jasman MH, Hafez P, Tan GH, Goh EH, Fam XI, Ho CC, Zainuddin , Rajan R, Mohd Nor F, Shuhaili M, Kosai NR, Imran FH, Ng MH
- KMID: 2455046
- Tissue Eng Regen Med.
- 2019 Aug;16(4):365-384.
- doi: 10.1007/s13770-019-00193-z
BACKGROUND: Urinary tract is subjected to a variety of disorders such as urethral stricture, which often develops as a result of scarring process. Urethral stricture can be treated by urethral... -
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- Role of DNA Methylation in the Development and Differentiation of Intestinal Epithelial Cells and Smooth Muscle Cells
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Jorgensen , Ro S
- KMID: 2454636
- J Neurogastroenterol Motil.
- 2019 Jul;25(3):377-386.
- doi: 10.5056/jnm19077
The mammalian intestine contains many different cell types but is comprised of 2 main cell types: epithelial cells and smooth muscle cells. Recent in vivo and in vitro evidence has... -
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- Benefits of Angiotensin Receptor Blockade: Preventing Smooth Muscle Cell Senescence and Beyond
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Song P, Kim JH
- KMID: 2450394
- Korean Circ J.
- 2019 Jul;49(7):627-628.
- doi: 10.4070/kcj.2019.0164
No abstract available. -
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- Angiotensin II Type 1 Receptor Blocker, Fimasartan, Reduces Vascular Smooth Muscle Cell Senescence by Inhibiting the CYR61 Signaling Pathway
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Kim I, Park CS, Lee HY
- KMID: 2450393
- Korean Circ J.
- 2019 Jul;49(7):615-626.
- doi: 10.4070/kcj.2018.0379
BACKGROUND AND OBJECTIVES: Angiotensin II (Ang II) has been suggested to accelerate vascular senescence, however the molecular mechanism(s) remain unknown. METHODS: We cultured human coronary artery smooth muscle cells (hCSMCs) and... -
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- Morphology of the human aorta and age-related changes: anatomical facts
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Komutrattananont P, Mahakkanukrauh P, Das S
- KMID: 2451212
- Anat Cell Biol.
- 2019 Jun;52(2):109-114.
- doi: 10.5115/acb.2019.52.2.109
Aorta is the largest artery in the human body. Its starting point is the aortic orifice of the aortic valve and it terminates at the level of the fourth lumbar... -
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- Stem Cells Seeded on Multilayered Scaffolds Implanted into an Injured Bladder Rat Model Improves Bladder Function
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Shrestha K, Jeon SH, Jung AR, Kim IG, Kim GE, Park YH, Kim SH, Lee JY
- KMID: 2449250
- Tissue Eng Regen Med.
- 2019 Apr;16(2):201-212.
- doi: 10.1007/s13770-019-00187-x
BACKGROUND: To investigate whether human adipose-derived stem cells (hADSCs) seeded on multilayered poly (L-lactide-co-ε-caprolactone) (PLCL) sheets improve bladder function in a rat model of detrusor smooth muscle-removed bladder. METHODS: Male rats... -
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- Control of Motility in the Internal Anal Sphincter
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Keef KD, Cobine CA
- KMID: 2449091
- J Neurogastroenterol Motil.
- 2019 Apr;25(2):189-204.
- doi: 10.5056/jnm18172
The internal anal sphincter (IAS) plays an important role in the maintenance of fecal continence since it generates tone and is responsible for > 70% of resting anal pressure. During... -
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- A Case of Subcutaneous Leiomyosarcoma of the Scalp
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Choi ME, Shin HJ, Chang SE, Lee MW, Choi JH, Lee WJ
- KMID: 2446919
- Korean J Dermatol.
- 2019 Mar;57(3):136-139.
Leiomyosarcoma is a rare and aggressive soft tissue sarcoma originating in smooth muscle cells. There are two forms of primary superficial leiomyosarcomas depending on the origin and prognosis, one derived... -
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- rBMSCs/ITGA5B1 Promotes Human Vascular Smooth Muscle Cell Differentiation via Enhancing Nitric Oxide Production
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Zhang Y, Ding J, Xu C, Yang H, Xia P, Ma S, Chen H
- KMID: 2429549
- Int J Stem Cells.
- 2018 Nov;11(2):168-176.
- doi: 10.15283/ijsc18079
BACKGROUND AND OBJECTIVES: Previous studies have shown that integrins alpha5beta1 (ITGA5B1) gene-modified rat bone marrow mesenchymal stem cells (rBMSCs) could prevent cell anoikis and increase the nitric oxide (NO) production.... -
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- Effect of Sphingosine-1-Phosphate on Intracellular Free Ca2+ in Cat Esophageal Smooth Muscle Cells
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Lee DK, Min YS, Yoo SS, Shim HS, Park SY, Sohn UD
- KMID: 2427507
- Biomol Ther.
- 2018 Nov;26(6):546-552.
- doi: 10.4062/biomolther.2018.053
A comprehensive collection of proteins senses local changes in intracellular Ca²⺠concentrations ([Ca²âº](i) and transduces these signals into responses to agonists. In the present study, we examined the effect of... -
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- Change of voltage-gated potassium channel 1.7 expressions in monocrotaline-induced pulmonary arterial hypertension rat model
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Lee H, Kim KC, Hong YM
- KMID: 2422365
- Korean J Pediatr.
- 2018 Sep;61(9):271-278.
- doi: 10.3345/kjp.2018.06457
PURPOSE: Abnormal potassium channels expression affects vessel function, including vascular tone and proliferation rate. Diverse potassium channels, including voltage-gated potassium (Kv) channels, are involved in pathological changes of pulmonary arterial... -
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- Inhibition of voltage-dependent K⺠current in rabbit coronary arterial smooth muscle cells by the class Ic antiarrhythmic drug propafenone
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An JR, Li H, Seo MS, Park WS
- KMID: 2419009
- Korean J Physiol Pharmacol.
- 2018 Sep;22(5):597-605.
- doi: 10.4196/kjpp.2018.22.5.597
In this study, we demonstrated the inhibitory effect of the Class Ic antiarrhythmic agent propafenone on voltage-dependent K⺠(Kv) channels using freshly isolated coronary artery smooth muscle cells from rabbits.... -
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- Microarray Analysis in Pulmonary Hypertensive Rat Heart after Simvastatin Treatment
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Kim YK, Kim KC, Hong YM
- KMID: 2417942
- Ewha Med J.
- 2018 Jul;41(3):53-62.
- doi: 10.12771/emj.2018.41.3.53
OBJECTIVES: Simvastatin has been reported to attenuate the development of pulmonary hypertension through increased apoptosis as well as reduced proliferation of smooth muscle cells in obstructive vascular lesions. Microarray experiment... -
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- Overexpression of miR-155-5p Inhibits the Proliferation and Migration of IL-13-Induced Human Bronchial Smooth Muscle Cells by Suppressing TGF-β-Activated Kinase 1/MAP3K7-Binding Protein 2
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Shi Y, Fu X, Cao Q, Mao Z, Chen Y, Sun Y, Liu Z, Zhang Q
- KMID: 2409061
- Allergy Asthma Immunol Res.
- 2018 May;10(3):260-267.
- doi: 10.4168/aair.2018.10.3.260
PURPOSE: Molecular mechanisms leading to asthma is still ill-defined. Though the function of microRNAs (miRNAs) in asthma was previously reported, the involvement of miR-155 in important features of this disease... -
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- Arginase II inhibition prevents interleukin-8 production through regulation of p38 MAPK phosphorylation activated by loss of mitochondrial membrane potential in nLDL-stimulated hAoSMCs
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Koo BH, Yi BG, Jeong MS, Kwon SH, Hoe KL, Kwon YG, Won MH, Kim YM, Ryoo S
- KMID: 2440020
- Exp Mol Med.
- 2018 Feb;50(2):e438.
- doi: 10.1038/emm.2017.254
Arginase inhibition exhibits beneficial effects in vascular endothelial and smooth muscle cells. In human aortic smooth muscle cells (hAoSMCs), native low-density lipoprotein (nLDL) induced the production of interleukin-8 (IL-8) that... -
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- Effects of corticotropin-releasing hormone on the expression of adenosine triphosphate-sensitive potassium channels (Kir6.1/SUR2B) in human term pregnant myometrium
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Kim JY, Wu WH, Jun JH, Sohn J, Seo YS
- KMID: 2420147
- Obstet Gynecol Sci.
- 2018 Jan;61(1):14-22.
- doi: 10.5468/ogs.2018.61.1.14
OBJECTIVE: Corticotropin-releasing hormone (CRH) is a crucial regulator of human pregnancy and parturition. Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels are important for regulating myometrial quiescence during pregnancy. We investigated regulatory... -
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