Korean J Med.  2004 Apr;66(4):383-388.

Prostacyclin synthase C1117A polymorphism is not associated with variant angina

• Seong IW
• Lim DS
• Kim JH
• Lee JH
• Choi SW
• Jeong JO

Abstract

BACKGROUND: Coronary artery spasm plays an important role in the pathogenesis of variant angina (VA). Prostacyclin is one of the endothelium derived relaxing factors. The association between the novel single nucleotide polymorphism in the prostacyclin synthase gene and VA is not known. Therefore, we investigated the association between VA and the polymorphysm in the prostacyclin synthase gene.
METHODS
We compared 45 variant angina patients who had positive intravenous ergonovine test by coronary angiography with 59 control subjects who had negative intravenous ergonovine test and normal coronary angiogram. Using the polymerase chain reaction-single-strand conformation polymorphism analysis, we identified a single nucleotide polymorphism, C1117A, in exon 8. This nucleotide change did not cause an amino acid change in codon 373.
RESULTS
There was no significant difference in characteristics between the control group and the VA group, and there was no significant difference in the genotype distributions between the control group and the VA group.
CONCLUSION
The C1117A polymorphism in exon 8 of the prostacyclin synthase gene is not associated with variant angina.

Keyword

Variant angina; Prostacyclin polymorphism

MeSH Terms

Codon
Coronary Angiography
Coronary Vessels
Endothelium-Dependent Relaxing Factors
Epoprostenol*
Ergonovine
Exons
Genotype
Humans
Polymorphism, Single Nucleotide
Spasm
Codon
Endothelium-Dependent Relaxing Factors
Epoprostenol
Ergonovine