J Rhinol.  2011 Nov;18(2):112-115.

Blood Level of Soluble CD30 and Soluble E-Selectin in Allergic Rhinitis Patients

Affiliations
  • 1Department of Otolaryngology-Head & Neck Surgery, Institute of Wonkwang Medical Science, School of Medicine, Wonkwang University, Iksan, Korea. nose-1023@hanmail.net

Abstract

BACKGROUND AND OBJECTIVES
Blood levels of soluble CD30 and soluble E-selectin are related to allergic diseases such as atopic dermatitis or asthma. However, these levels have not been well investigated in allergic rhinitis. We evaluated the association of blood concentrations of these cytokines in allergic rhinitis.
MATERIALS AND METHODS
The concentrations of soluble CD30 and soluble E-selectin in blood were analyzed by enzyme linked immunosorbant assay. The levels of these cytokines were compared between allergic rhinitis patients (n=48) and age-matched healthy controls (n=27), and a relationship was found with symptom severity. RESULT: The concentration of soluble CD30 was significantly increased in allergic rhinitis patients compared to that in normal healthy people (p=0.042). However, soluble E-selectin was not significantly increased in allergic rhinitis patients (p>0.05).
CONCLUSION
These results suggest a possible role of soluble CD30 in the blood of allergic rhinitis.

Keyword

Allergic rhinitis; CD30; E-selectin
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