J Korean Acad Fam Med.  2000 Jun;21(6):782-791.

Effects of changes in lifestyle and biological parameters on blood lipid levels in middle aged men

Affiliations
  • 1Department of Family Medicine, Seoul Hanil General Hospital, Korea.

Abstract

BACKGROUND
Death from coronary heart disease is increasing and this study is to evaluate the effect of longitudinal changes of lifestyle and biological parameters on the blood lipid levels, as the risk factor of the coronary heart disease.
METHODS
Total cholesterol and total cholesterol to HDL-cholesterol ratio (atherosclerogenic index) as an indicator for risk of coronary heart disease were examined longitudinally in a sample (n = 463) of middle-aged men by 2 years. The independent variables were body mass index, smoking, alcohol, exercise, diastolic blood pressure, uric acid. All data was drawn from questionnaire, blood chemistry, and review of chart.
RESULTS
ANOVA test according to categorized variables revealed that for total cholesterol, uric acid (P<0.01) and diastolic blood pressure (P<0.01), and for atherosclerogenic index, and body mass index (P<0.001) were significant. In correlation analysis, total cholesterol was associated with uric acid (r=0.20, P<0.001), diastolic blood pressure (r=0.15, P <0.001) and body mass index (r=0.03, P<0.05), and for atherosclerogenic index so was body mass index (r=0.18, P<0.001). In regression, uric acid (beta=6.07, P <0.001), diastolic blood pressure (beta=0.36, P <0.01) for total cholesterol, and body mass index (beta=0.22, P <0.001) for atherosclerogenic index were significant. But changes in alcohol consumption, smoking, and exercise were not statistically significant.
CONCLUSION
In order to reduce risks of coronary heart disease, the more aggressive medical intervention for the uric acid, DBP, and BMI, would be essential. This study was done without medical intervention. So, further study with intervention, adequate duration and intensity for parameters modification is required.

Keyword

Coronary heart disease; Lifestyle modifications; Diastolic blood pressure; Uric acid; Cholesterol; Atherosclerogenic index

MeSH Terms

Alcohol Drinking
Blood Pressure
Body Mass Index
Chemistry
Cholesterol
Coronary Disease
Humans
Life Style*
Male
Middle Aged*
Risk Factors
Smoke
Smoking
Uric Acid
Surveys and Questionnaires
Cholesterol
Smoke
Uric Acid
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