J Asthma Allergy Clin Immunol.
2003 Sep;23(3):467-473.
O-glucogenistein inhibits eosinophil recruitment and nasal allergic symptoms in a murine model of nasal allergy
- Affiliations
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- 1Department of Otorhinolaryngology, Chungbuk National University, Cheongjoo, Korea.
- 2Department of Diagnostic Pathology, Chungbuk National University, Cheongjoo, Korea.
- 3Department of Internal Medicine, College of medicine and Medical Research Institute, Chungbuk National University Cheongjoo, Korea. mkkim@med.chungbuk.ac.kr
- 4College of Pharmacy, Chungbuk National University, Cheongjoo, Korea.
- 5College of Pharmacy, Chungnam National University, Daejeon, Korea.
- 6College of Pharmacy, Yeungnam University Daegu, Korea.
- 7Toxicology laboratory Korean Institute of Science and Technology, Seoul, Korea.
Abstract
- BACKGROUND
Infiltration of eosinophils in the nasal mucosa is a consistent feature of nasal allergic inflammation. Various cytokines, especially interleukin-5(IL-5), were identified to play important roles in the infiltration and activation of eosinophils in nasal mucosa. Our previous study found that among 4 kinds of sophoricosides extracted from Sophora japonica, named sophi, orobol, genistin, and genistein, 3 compounds except genistein known as protein tyrosine kinase(PTK) inhibitor had anti-inflammatory and anti-IL-5 effects, and sophi was the most potent.
OBJECTIVE
The goal of this study was to investigate the antagonism of sophi on the nasal eosinophilia in ovalbumin(OA)-sensitized murine nasal allergy model. METHODS: Male BALB/c mice sensitized intraperitoneally and then topically with OA were treated with sophi(10 or 30mg/kg) or anti-mouse IL-5 monoclonal antibody(anti-IL-5 mAb, 1mg/Kg) intravenously 1 hour before challenge. The effect of sophi on the infiltration of eosinophils into the nasal mucosa, peripheral blood eosinophilia, nasal symptom, and OA-specific IgE antibody production were evaluated.
Results
Administration of sophi(10, 30mg/kg) significantly inhibited the nasal eosinophil infiltration and nasal symptom compared to that of anti-IL-5 mAb. But eosinophil count inthe peripheral blood and the titer of OA-specific IgE were not affected by sophi. CONCLUSION: Sophi inhibited not only the tissue eosinophilia but also the acute nasal allergic symptom. These findings suggest that sophi has anti-eosinophilic cytokine activity and also plays blockade of early allergic reaction. Taken together, sophi may be a candidate for new anti-allergic medicine.
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