- Genistein Inhibits Proliferation of BRCA1 Mutated Breast Cancer Cells: The GPR30-Akt Axis as a Potential Target
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Kim GY, Suh J, Jang JH, Kim DH, Park OJ, Park SK, Surh YJ
- KMID: 2468809
- J Cancer Prev.
- 2019 Dec;24(4):197-207.
- doi: 10.15430/JCP.2019.24.4.197
BACKGROUND: BRCA1 mutated breast cancer cells exhibit the elevated cell proliferation and the higher metastatic potential. G protein-coupled receptor 30 (GPR30) has been shown to regulate growth of hormonally responsive... -
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- Effects of genistein on anti-tumor activity of cisplatin in human cervical cancer cell lines
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Liu H, Lee G, Lee JI, Ahn TG, Kim SA
- KMID: 2456827
- Obstet Gynecol Sci.
- 2019 Sep;62(5):322-328.
- doi: 10.5468/ogs.2019.62.5.322
OBJECTIVE: To investigate the effect of genistein on the anticancer effects of chemotherapeutic agents, we examined the effect of a genistein and cisplatin combination on CaSki human cervical cancer cells. METHODS:... -
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- Effect of Isoflavones and Genistein on Glucose Metabolism in Peri- and Post-Menopausal Women: An Overview of Meta-Analysis
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Maliehe A, Ghahremani S, Kharghani , Ghazanfarpour M, Shariati K, Kazemi M, Khadivzadeh T
- KMID: 2466841
- J Menopausal Med.
- 2019 Aug;25(2):69-73.
- doi: 10.6118/jmm.18143
The purpose of the present overview of meta-analysis is to summarize and critically assess the effect of isoflavones and genistein on glucose metabolism among the peri- and post-menopausal women. Two... -
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- Genistein improve nicotine toxicity on male mice pancreas
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Salahshoor MR, Mirzaei F, Roshankhah S, Jalili P, Jalili C
- KMID: 2451222
- Anat Cell Biol.
- 2019 Jun;52(2):183-190.
- doi: 10.5115/acb.2019.52.2.183
Nicotine is the most toxic factor of tobacco. Genistein is a phytoestrogen and antioxidant that has numerous health benefits. The aim of this study is to evaluate the effects of... -
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- Genistein Improves the Major Depression through Suppressing the Expression of miR-221/222 by Targeting Connexin 43
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Shen F, Huang WL, Xing BP, Fang X, Feng M, Jiang CM
- KMID: 2425502
- Psychiatry Investig.
- 2018 Oct;15(10):919-925.
- doi: 10.30773/pi.2018.06.29
OBJECTIVE: Recent studies have indicated the possibility that genistein may improve depression via regulating the expression of miR-221/222. This study is to explore whether genistein could improve depression by altering... -
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- Genistein attenuates isoflurane-induced neurotoxicity and improves impaired spatial learning and memory by regulating cAMP/CREB and BDNF-TrkB-PI3K/Akt signaling
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Jiang T, Wang XQ, Ding C, Du XL
- KMID: 2395252
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):579-589.
- doi: 10.4196/kjpp.2017.21.6.579
Anesthetics are used extensively in surgeries and related procedures to prevent pain. However, there is some concern regarding neuronal degeneration and cognitive deficits arising from regular anesthetic exposure. Recent studies... -
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- Absorption Study of Genistein Using Solid Lipid Microparticles and Nanoparticles: Control of Oral Bioavailability by Particle Sizes
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Kim JT, Barua S, Kim H, Hong SC, Yoo SY, Jeon H, Cho Y, Gil S, Oh K, Lee J
- KMID: 2386913
- Biomol Ther.
- 2017 Jul;25(4):452-459.
- doi: 10.4062/biomolther.2017.095
In this study, the effect of particle size of genistein-loaded solid lipid particulate systems on drug dissolution behavior and oral bioavailability was investigated. Genistein-loaded solid lipid microparticles and nanoparticles were... -
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- Chemical Components from the Stems of Pueraria lobata and Their Tyrosinase Inhibitory Activity
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Morgan AM, Jeon MN, Jeong MH, Yang SY, Kim YH
- KMID: 2328876
- Nat Prod Sci.
- 2016 Jun;22(2):111-116.
- doi: 10.20307/nps.2016.22.2.111
Phytochemical investigation of the stems of Pueraria lobata (Wild) Ohwi (Leguminosae), led to the isolation of eighteen known compounds: β-amyrone (1), (+)-pinoresinol (2), (+)-syringaresinol (3) (+)-syringaresinol-O-β-D-glucoside (4), (+)-lariciresinol (5), (-)-tuberosin... -
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- The Resveratrol-induced Relaxation of Cholecystokinin Octapeptide- or KCl-induced Tension in Male Guinea Pig Gallbladder Strips Is Mediated Through L-type Ca2+ Channels
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Kline LW, Karpinski
- KMID: 2381232
- J Neurogastroenterol Motil.
- 2015 Jan;21(1):62-68.
- doi: 10.5056/jnm14093
BACKGROUND/AIMS: Resveratrol (3,5,4'-trihydroxystilbene) is a polyphenolic compound (stilbene) and a phytoalexin. The purpose of this study was to determine the mechanism which mediated the resveratrol-induced relaxation of cholecystokinin octapeptide- or... -
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- Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans
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Lee EB, Ahn D, Kim BJ, Lee SY, Seo HW, Cha YS, Jeon H, Eun JS, Cha DS, Kim DK
- KMID: 2380366
- Biomol Ther.
- 2015 Jan;23(1):77-83.
- doi: 10.4062/biomolther.2014.075
The seed of Vigna angularis has long been cultivated as a food or a folk medicine in East Asia. Genistein (4',5,7-trihydroxyisoflavone), a dietary phytoestrogen present in this plant, has been... -
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- Elucidation of the Inhibitory Effect of Phytochemicals with Kir6.2 Wild-Type and Mutant Models Associated in Type-1 Diabetes through Molecular Docking Approach
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Jagadeb M, Konkimalla VB, Rath SN, Das RP
- KMID: 2391509
- Genomics Inform.
- 2014 Dec;12(4):283-288.
- doi: 10.5808/GI.2014.12.4.283
Among all serious diseases globally, diabetes (type 1 and type 2) still poses a major challenge to the world population. Several target proteins have been identified, and the etiology causing... -
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- Chemopreventive and chemotherapeutic effects of genistein, a soy isoflavone, upon cancer development and progression in preclinical animal models
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Kim SH, Kim CW, Jeon SY, Go RE, Hwang KA, Choi KC
- KMID: 1737415
- Lab Anim Res.
- 2014 Dec;30(4):143-150.
- doi: 10.5625/lar.2014.30.4.143
Genistein is one of isoflavones mostly derived in a leguminous plant. It is well known as one of phytoestrogens that have structures similar to the principal mammalian estrogen. It has... -
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- What Equol Can Do for Human Health?
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Usui T
- KMID: 2271038
- Korean J Obes.
- 2014 Mar;23(1):1-5.
Although soy is considered to be beneficial for various health problems, including postmenopausal symptoms, osteoporosis, lipid metabolism, and obesity based on several human studies, the effects of soy intake on... -
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- Plasma pharmacokinetics and urinary excretion of isoflavones after ingestion of soy products with different aglycone/glucoside ratios in South Korean women
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Chang Y, Choue R
- KMID: 1841311
- Nutr Res Pract.
- 2013 Oct;7(5):393-399.
- doi: 10.4162/nrp.2013.7.5.393
Asian populations are thought to receive significant health benefits from traditional diets rich in soybeans due to high isoflavone contents. However, available epidemiologic data only weakly support this hypothesis. The... -
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- Effect of genistein administration on the recovery of spermatogenesis in the busulfan-treated rat testis
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Chi H, Chun K, Son H, Kim J, Kim G, Roh S
- KMID: 1493211
- Clin Exp Reprod Med.
- 2013 Jun;40(2):60-66.
- doi: 10.5653/cerm.2013.40.2.60
OBJECTIVE: Impairment of spermatogenesis has been identified as an inevitable side effect of cancer treatment. Although estrogen treatment stimulates spermatogenic recovery from the impaired spermatogenesis by suppressing the intra-testicular testosterone... -
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- The Synergistic Apoptotic Interaction of Indole-3-Carbinol and Genistein with TRAIL on Endometrial Cancer Cells
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Parajuli B, Shin SJ, Kwon SH, Cha SD, Lee HG, Bae I, Cho CH
- KMID: 1786959
- J Korean Med Sci.
- 2013 Apr;28(4):527-533.
- doi: 10.3346/jkms.2013.28.4.527
Induction of apoptosis in target cells is a key mechanism by which chemotherapy promotes cell killing. The purpose of this study was to determine whether Indole-3-Carbinol (I3C) and Genistein in... -
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- Expression of DNA Methyltransferases in Breast Cancer Patients and to Analyze the Effect of Natural Compounds on DNA Methyltransferases and Associated Proteins
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Mirza S, Sharma G, Parshad R, Gupta SD, Pandya P, Ralhan R
- KMID: 2374541
- J Breast Cancer.
- 2013 Mar;16(1):23-31.
PURPOSE: The DNA methylation mediated by specific DNA methyltransferases (DNMTs), results in the epigenetic silencing of multiple genes which are implicated in human breast cancer. We hypothesized that the natural... -
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- Dietary Isoflavone Intake, Urinary Isoflavone Level, and Their Relationship with Metabolic Syndrome Diagnostic Components in Korean Postmenopausal Women
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Kim MH, Bae YJ
- KMID: 2279716
- Clin Nutr Res.
- 2013 Jan;2(1):59-66.
- doi: 10.7762/cnr.2013.2.1.59
Recent studies have suggested that natural agents such as isoflavones, resveratrol, and anthocyanin have beneficial effects on metabolic syndrome-related disorders. The objective of this study was to evaluate dietary isoflavone... -
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- Preferential Cytotoxic Effect of Genistein on G361 Melanoma Cells Via Inhibition of the Expression of Focal Adhesion Kinase
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Park SR, Kwak HH, Park BS, Kim GC
- KMID: 1431133
- Int J Oral Biol.
- 2012 Dec;37(4):189-195.
Resistance to the induction of apoptosis is a possible mechanism by which tumor cells can survive anti-neoplastic treatments. Melanoma is notoriously resistant to anti-neoplastic therapy. Previous studies have demonstrated focal... -
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- Aggregatibacter actinomycetemcomitans Strongly Stimulates Endothelial Cells to Produce Monocyte Chemoattractant Protein-1 and Interleukin-8
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Choi EK, Kang MS, Oh BH, Kim SY, Kim SH, Kang IC
- KMID: 1436488
- Int J Oral Biol.
- 2012 Sep;37(3):137-145.
Aggregatibacter actinomycetemcomitans is the most important etiologic agent of aggressive periodontitis and can interact with endothelial cells. Monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) are chemokines, playing important roles in... -
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