Clin Nutr Res.  2013 Jan;2(1):76-79. 10.7762/cnr.2013.2.1.76.

Wheat-Induced Anaphylaxis in Korean Adults: A Report of 6 Cases

  • 1Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-744, Korea.
  • 2Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul 110-744, Korea.
  • 3Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 463-707, Korea.


Wheat is a common cause of food allergy. Wheat-induced anaphylaxis (WIA) and wheat-dependent exercise induced anaphylaxis (WDEIA) are severe forms of immunoglobulin E (IgE) mediated allergic reaction to wheat protein. As the diagnosis of WIA or WDEIA is not easy because of the risk of oral challenge, identification of specific IgE of various wheat proteins is helpful for diagnosis. In Korea, there are only a few reports on WIA in adults. We report six cases of WIA diagnosed on the basis of clinical history and specific IgE of wheat proteins or provocation test. For immunologic evaluation of severe wheat allergy including WIA and WDEIA, it is important to measure specific IgE to each component of wheat including gluten and omega-5 gliadin not just measuring wheat-specific IgE.


Wheat allergy; Anaphylaxis; Immunoglobulin E

MeSH Terms

Food Hypersensitivity
Immunoglobulin E
Wheat Hypersensitivity
Immunoglobulin E

Cited by  2 articles

Usefulness of specific IgE antibody levels to wheat, gluten, and ω-5 gliadin for wheat allergy in Korean children
Jongseo Yoon, Kyunguk Jeong, Sooyoung Lee
Allergy Asthma Respir Dis. 2016;4(2):119-125.    doi: 10.4168/aard.2016.4.2.119.

Analysis of clinical characteristics of food-dependent exercise-induced anaphylaxis at a single tertiary hospital
Soo Jie Chung, Jisu Shim, Hyung-Jun Kim, Kyoung-Hee Sohn, Sung-Yoon Kang, Min-Gyu Kang, Han-Ki Park, Hye-Ryun Kang
Allergy Asthma Respir Dis. 2016;4(6):436-441.    doi: 10.4168/aard.2016.4.6.436.


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