Allergy Asthma Immunol Res.  2014 Jul;6(4):370-372. 10.4168/aair.2014.6.4.370.

Wheat - Dependent Exercise-Induced Anaphylaxis Occurred With a Delayed Onset of 10 to 24 hours After Wheat Ingestion: A Case Report

  • 1Department of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.


Wheat-dependent exercise-induced anaphylaxis (WDEIA) usually occurs 1 to 4 hours after wheat ingestion and the pathophysiology of WDEIA remains unknown. It is recommended that WDEIA patients refrain from exercise for 4 to 6 hours after wheat ingestion. We report a case of a 51-year-old man who experienced 5 anaphylaxis attacks; two of which occurred 10 to 24 hours after wheat ingestion and exercise. He has a history of chronic gastroenteritis that responds well to antihistamine drugs but not proton pump inhibitors (PPIs) and prokinetic agents. Abdominal CT results implied the possibility of superior mesenteric artery syndrome. We suggest that WDEIA occurs 6 hours after wheat ingestion in cases compounded by obstructive gastrointestinal diseases.


Wheat-dependent exercise-induced anaphylaxis; chronic gastroenteritis; superior mesenteric artery syndrome

MeSH Terms

Gastrointestinal Diseases
Middle Aged
Proton Pump Inhibitors
Superior Mesenteric Artery Syndrome
Tomography, X-Ray Computed
Proton Pump Inhibitors


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