Korean J Obes.  2005 Jun;14(2):69-75.

Cutoff Values of Surrogate Measures of Insulin Resistance for Metabolic Syndrome in Korean Non-diabetic Adults

Affiliations
  • 1Department of Endocrinology and Metabolism, Ajou University School of Medicine, Korea. djkim@ajou.ac.kr
  • 2Huh's Diabetes Center and the 21th century Diabetes and Vascular Research Institute, Korea.

Abstract


OBJECTIVE
We investigated the cutoff values of surrogate measures of insulin resistance for diagnosing metabolic syndrome in Korean adults. RESARCH DESIGN and METHODS: This study was conducted as part of the Korean Metabolic Syndrome(KMS) Study. The data from 976 non-diabetic individuals(484 men and 492 women) aged 30~79 years were analyzed. We determined the odds ratios for the prevalence of metabolic syndrome according to the quartiles of fasting insulin, homeostasis model assessment for insulin resistance(HOMA-IR), and quantitative insulin sensitivity check index(QUICKI) as independent variables, while adjusting for age, sex, and body mass index. The areas under the receiver-operating characteristic(ROC) curves for fasting insulin, HOMA-IR, and QUICKI for increased metabolic syndrome were compared, and the cutoff values of fasting insulin, HOMA-IR, and QUICKI were estimated.
RESULTS
The cutoff points for defining insulin resistance are a fasting insulin level of 12.94micronU/mL, HOMA-IR= 3.04 as the 75th percentile value, and QUICKI = 0.32 as the 25th percentile value. Compared with the lowest quartile, the adjusted odds ratios for the prevalence of metabolic syndrome in the highest quartiles of fasting insulin, HOMA-IR, and QUICKI were 1.95(1.26~3.01), 2.27(1.45~3.56), and 2.27(1.45~3.56), respectively. The respective cutoff values for fasting serum insulin, HOMA-IR, and QUICKI by ROC analysis were 10.57micronU/mL(sensitivity 58.5%, specificity 66.8%), 2.34(sensitivity 62.8%, specificity 65.7%), and 0.33(sensitivity 61.2%, specificity 66.8%).
CONCLUSIONS
Fasting insulin, HOMA-IR, and QUICKI are good surrogate measures of insulin resistance in Korean non-diabetic adults. We suggest that the cutoff values using these simple methods could be applied to evaluate insulin resistance and predict metabolic syndrome in Korean non-diabetic adults.

Keyword

Insulin resistance; Metabolic syndrome; Insulin; HOMA; QUICKI

MeSH Terms

Adult*
Body Mass Index
Fasting
Homeostasis
Humans
Insulin Resistance*
Insulin*
Male
Odds Ratio
Prevalence
ROC Curve
Sensitivity and Specificity
Insulin
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