Korean J Obstet Gynecol.  2001 Feb;44(2):273-276.

Expression of Epidermal Growth Factor, Transforming Growth Factor-alpha and Epidermal Growth Factor Receptor in Human Cervical Neoplasia

Affiliations
  • 1Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract


OBJECTIVE
This study seeks to define the expression of epidermal growth factor(EGF) and transforming growth factor(TGF)-alpha and epidermal growth factor receptor(EGFR), and the relationship to the tumor progression of human cervical epithelial neoplasia.
METHODS
To confirm the expression of EGF, TGF-alpha and EGFR immunohistochemically in normal cervix, cervical intraepithelial neoplasms and cervical carcinomas, we used monoclonal antibodies to EGF, TGF-alpha and EGFR.
RESULTS
Immunohistochemical stainings using anti-EGF, anti-TGF-alpha and anti-EGFR antibodies showed weak or moderate stainings in all cases. Normal and CIN cases showed predominantly basal and parabasal expression of EGF, TGF-alpha and EGFR, and its expression decreased as the cells became increasingly differentiated toward the surface of the epithelium. In the cervical carcinoma EGF and TGF-alpha expressed weakly to moderately focally, and EGFR expressed intensely in all malignant cells.
CONCLUSION
These results suggest that EGF, TGF-alpha and EGFR may involved in cellular proliferation of cervical squamous epithelium and have a significant role in the progression of cervical cancer.

Keyword

Cervix; Epidermal growth factor; Transforming growth factor-alpha; Epidermal growth factor receptor

MeSH Terms

Antibodies
Antibodies, Monoclonal
Cell Proliferation
Cervical Intraepithelial Neoplasia
Cervix Uteri
Epidermal Growth Factor*
Epithelium
Female
Humans
Receptor, Epidermal Growth Factor*
Transforming Growth Factor alpha
Uterine Cervical Neoplasms
Antibodies
Antibodies, Monoclonal
Epidermal Growth Factor
Receptor, Epidermal Growth Factor
Transforming Growth Factor alpha
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