- Silibinin Radiosensitizes EGF Receptor-knockdown Prostate Cancer Cells by Attenuating DNA Repair Pathways
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Rajput M, Mishra D, Kumar K, Singh RP
- KMID: 2533966
- J Cancer Prev.
- 2022 Sep;27(3):170-181.
- doi: 10.15430/JCP.2022.27.3.170
Emergence of radioresistance in prostate cancer (PCa) cells is a major obstacle in cancer therapy and contributes to the relapse of the disease. EGF receptor (EGFR) signaling plays an important... -
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- Landscape of EGFR mutations in lung adenocarcinoma: a single institute experience with comparison of PANAMutyper testing and targeted next-generation sequencing
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Lee J, Han YB, Kwon HJ, Lee SK, Kim H, Chung JH
- KMID: 2533701
- J Pathol Transl Med.
- 2022 Sep;56(5):249-259.
- doi: 10.4132/jptm.2022.06.11
Background: Activating mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) are predictive biomarkers for response to EGFR–tyrosine kinase inhibitor (TKI) therapy in lung adenocarcinoma (LUAD). Here,... -
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- Combination of 18 F-Fluorodeoxyglucose PET/CT Radiomics and Clinical Features for Predicting Epidermal Growth Factor Receptor Mutations in Lung Adenocarcinoma
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Li S, Li Y, Zhao M, Wang P, Xin J
- KMID: 2532659
- Korean J Radiol.
- 2022 Sep;23(9):921-930.
- doi: 10.3348/kjr.2022.0295
Objective: To identify epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma based on 18 F-fluorodeoxyglucose (FDG) PET/CT radiomics and clinical features and to distinguish EGFR exon 19 deletion (19... -
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- Lazertinib: on the Way to Its Throne
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Lee J, Hong MH, Cho BC
- KMID: 2532714
- Yonsei Med J.
- 2022 Sep;63(9):799-805.
- doi: 10.3349/ymj.2022.63.9.799
Lazertinib is an oral, irreversible, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that forms an irreversible covalent bond to the Cys797 residue in the ATP-binding site of... -
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- Prognostic outcome of treatment modalities for epidermal growth factor receptor-mutated advanced lung cancer
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Jang SH, Lee DY, Jeong J, Choi WI
- KMID: 2531480
- Korean J Intern Med.
- 2022 Jul;37(4):811-820.
- doi: 10.3904/kjim.2021.488
Background/Aims: The treatment of epidermal growth factor receptor (EGFR)-mutated lung cancer cases has shown remarkable development in the past two decades. However, there have been limited studies comparing the prognostic... -
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- miR-4487 Enhances Gefitinib-Mediated Ubiquitination and Autophagic Degradation of EGFR in Non-Small Cell Lung Cancer Cells by Targeting USP37
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Kim MS, Kim SH, Yang SH, Kim MS
- KMID: 2528214
- Cancer Res Treat.
- 2022 Apr;54(2):445-457.
- doi: 10.4143/crt.2021.622
Purpose With the identification of epidermal growth factor receptor (EGFR) mutations in non–small cell lung cancer (NSCLC) cells, EGFR–tyrosine kinase inhibitors (TKIs) are being used widely as the first-line of treatment... -
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- The efficacy of EGFR-tyrosine kinase inhibitor in non-small cell lung cancer patients with synchronous brain metastasis: a real-world study
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Choi JH, Choi YW, Lee HW, Kang SY, Jeong GS, Ahn MS, Oh YT, Noh Ok, Kim SH, Roh TH, Sheen SS
- KMID: 2527306
- Korean J Intern Med.
- 2022 Mar;37(2):434-443.
- doi: 10.3904/kjim.2021.315
Background/Aims: The optimal treatment (Tx) for epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) patients with brain metastasis (BM) remains to be determined. Methods: A retrospective review was conducted... -
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- Analysis of risk factors associated with survival in human epidermal growth factor receptor 2-positive ductal carcinoma in situ using Korean Breast Cancer Society Database
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Ahn SJ, Yoon CI, Paik PS, Yoo TK, Park N, Lee ES, Choi JE, Jeong J, Youn HJ, Park WC
- KMID: 2522927
- Ann Surg Treat Res.
- 2021 Dec;101(6):315-321.
- doi: 10.4174/astr.2021.101.6.315
Purpose: This study was performed to identify the risk of mortality in patients diagnosed with human epidermal growth factor receptor 2 (HER2)-positive ductal carcinoma in situ (DCIS). Methods: We... -
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- Objective Quantitation of EGFR Protein Levels using Quantitative Dot Blot Method for the Prognosis of Gastric Cancer Patients
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Xin L, Tang F, Song B, Yang M, Zhang J
- KMID: 2526332
- J Gastric Cancer.
- 2021 Dec;21(4):335-351.
- doi: 10.5230/jgc.2021.21.e32
Purpose: An underlying factor for the failure of several clinical trials of anti-epidermal growth factor receptor (EGFR) therapies is the lack of an effective method to identify patients who overexpress... -
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- Tissue Adequacy and Safety of Percutaneous Transthoracic Needle Biopsy for Molecular Analysis in Non-Small Cell Lung Cancer: A Systematic Review and Meta-analysis
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Nam BD, Yoon SH, Hong H, Hwang JH, Goo JM, Park S
- KMID: 2522945
- Korean J Radiol.
- 2021 Dec;22(12):2082-2093.
- doi: 10.3348/kjr.2021.0244
Objective: We conducted a systematic review and meta-analysis of the tissue adequacy and complication rates of percutaneous transthoracic needle biopsy (PTNB) for molecular analysis in patients with non-small cell lung... -
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- Expression of Estrogen and Progesterone Receptors in Papillary Thyroid Carcinoma in Korea
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Ahn HY, Song RY, Ahn HS, Kim HS
- KMID: 2521595
- Cancer Res Treat.
- 2021 Oct;53(4):1204-1212.
- doi: 10.4143/crt.2020.1201
Purpose The aim of this study was to examine the rate of expression of estrogen receptor α (ERα) and β1 (ERβ1), progesterone receptor (PR), and rate of overexpression of epidermal... -
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- Topical onion juice mitigates the morphological alterations of the cornea in the aged male rats
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Abdel Fattah IO, Madani GA, Nasr El-Din WA
- KMID: 2521050
- Anat Cell Biol.
- 2021 Sep;54(3):375-386.
- doi: 10.5115/acb.21.077
Aging is associated with structural and functional changes of the cornea. Fresh onion juice contains phenolic compounds and flavonoids that may provide an anti-aging effect. The aim of this study... -
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- Characteristics of HER2-Positive Breast Cancer according to HER2 2+/ Low or 3+/High Classification by Immunohistochemistry Assay: Study of 205 Cases Treated in a Single Center
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Lee C, Park I, Kim J, Cho H, Yang K, Lee Y, Park K, Kim J, Shin Y, Gwak G
- KMID: 2517016
- J Breast Dis.
- 2021 Jun;9(1):1-9.
- doi: 10.14449/jbd.2021.9.1.1
Purpose: To investigate the characteristics of HER2-positive breast cancer according to HER2 low (2+) or high (3+) classification using immunohistochemistry (IHC). Methods: Data were collected from 205 HER2-positive breast cancer... -
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- A case of concomitant EGFR/ALK alteration against a mutated EGFR background in early-stage lung adenocarcinoma
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Lee KC, Koh J, Chung DH, Jeon YK
- KMID: 2513900
- J Pathol Transl Med.
- 2021 Mar;55(2):139-144.
- doi: 10.4132/jptm.2020.12.16
Rare cases of lung adenocarcinoma (LUAD) with concomitant epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) translocation have been reported. However, their clonal and evolutional relationship remains... -
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- The Effect of Epidermal Growth Factor Receptor Mutation on Intracranial Progression-Free Survival of Non-Small Cell Lung Cancer Patients with Brain Metastasis Underwent Gamma Knife Radiosurgery
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Yang SH, Kim HY, Lee Si, Jin SJ
- KMID: 2507785
- Brain Tumor Res Treat.
- 2020 Oct;8(2):e15.
- doi: 10.14791/btrt.2020.8.e15
Background The aim of this study was to survey prognostic factors, particularly those focusing on epidermal growth factor receptor (EGFR) mutations, of patients with non-small cell lung cancer (NSCLC) after... -
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- Development of an Operational Plan for the Liquid Biopsy External Quality Assessment Program in Korea
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Ahn S, Kim HK, Kim JH, Lee W, Chun S, Lee WG, Min WK
- KMID: 2503719
- Lab Med Qual Assur.
- 2020 Jun;42(2):91-96.
- doi: 10.15263/jlmqa.2020.42.2.91
Background: Liquid biopsy is a useful assay for the diagnosis, treatment, and prognosis prediction of solid tumors and its clinical application is expanding. Therefore, the need for developing an External... -
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- Current status and future perspectives of liquid biopsy in non-small cell lung cancer
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Chang S, Hur JY, Choi YL, Lee CH, Kim WS
- KMID: 2501655
- J Pathol Transl Med.
- 2020 May;54(3):204-212.
- doi: 10.4132/jptm.2020.02.27
With advances in target therapy, molecular analysis of tumors is routinely required for treatment decisions in patients with advanced non-small cell lung cancer (NSCLC). Liquid biopsy refers to the sampling... -
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- Detection of Targetable Genetic Alterations in Korean Lung CancerPatients: A Comparison Study of Single-Gene Assays andTargeted Next-Generation Sequencing
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Park E, Shim HS
- KMID: 2500339
- Cancer Res Treat.
- 2020 Apr;52(2):543-551.
- doi: 10.4143/crt.2019.305
Purpose Epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and ROS proto-oncogene 1 (ROS1) are ‘must-test’ biomarkers in the molecular diagnostics of advanced- stage lung cancer patients. Although single-gene assays are currently... -
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- First In-Human Medical Imaging with a PASylated 89Zr-LabeledAnti-HER2 Fab-Fragment in a Patient with Metastatic Breast Cancer
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Richter A, Knorr K, Schlapschy M, Robu S, Morath V, Mendler C, Yen HY, Steiger K, Kiechle M, Weber W, Skerra A, Schwaiger M
- KMID: 2500065
- Nucl Med Mol Imaging.
- 2020 Apr;54(2):114-119.
- doi: 10.1007/s13139-020-00638-7
Purpose PASylation® offers the ability to systematically tune and optimize the pharmacokinetics of protein tracers for molecular imaging. Here we report the first clinical translation of a PASylated Fab fragment (89Zr∙Df-HER2-Fab-PAS200)... -
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- Analysis of the molecular subtypes of preoperative core needle biopsy and surgical specimens in invasive breast cancer
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Jeong YS, Kang J, Lee J, Yoo TK, Kim SH, Lee A
- KMID: 2501596
- J Pathol Transl Med.
- 2020 Jan;54(1):87-94.
- doi: 10.4132/jptm.2019.10.14
Background: Accurate molecular classification of breast core needle biopsy (CNB) tissue is important for determining neoadjuvant systemic therapies for invasive breast cancer. The researchers aimed to evaluate the concordance rate... -
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