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Menetrier's Disease: Its Mimickers and Pathogenesis

Huh WJ, Coffey RJ, Washington MK

Menetrier's disease is a rare protein-losing hypertrophic gastropathy. Histologically, it can be mistaken for other disorders showing hypertrophic gastropathy. The pathogenesis of Menetrier's disease is not fully understood; however, it...
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Asian Sand Dust Enhances Allergen-Induced Th2 Allergic Inflammatory Changes and Mucin Production in BALB/c Mouse Lungs

Kang IG, Jung JH, Kim ST

PURPOSE: Recent studies have reported that Asian sand dust (ASD) has a potential risk of aggravating airway inflammation. The purpose of this study was to investigate the effect of ASD...
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Expression of ErbB Receptor Proteins and TGF-alpha during Diethylnitrosamine-induced Hepatocarcinogenesis in the Rat Liver

Lee TY, Kim KT, Han SY

  • KMID: 760707
  • Korean J Hepatol.
  • 2007 Mar;13(1):70-80.
BACKGROUND/AIMS: ErbB receptor proteins are transmembrane tyrosine kinase receptors; when they are activated by interaction with ligands, they generate diverse cellular responses, especially during lesion development and progression to...
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Urinary Transforming Growth Factor-beta-inducible Gene-h3 in Patients with Glomerular Diseases

Hong HJ, Kim SD, Lee BC, Yoon HJ, Bae EH, Cho BS

  • KMID: 2254160
  • Korean J Nephrol.
  • 2006 Mar;25(2):229-234.
BACKGOUND: Transforming growth factor-beta (TGF-alpha) has been implicated in the pathogenesis of a number of kidney diseases. However, TGF-alpha is secreted in a latent form requiring extracellular modification to become...
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Regulation of the apoptosis on the rat granulosa cell: effects of EGF, TGF-alpha

Jo HH, Hwang SJ, Kim HY, Kim MR, Kwon DJ, Kim JH, Kim JH

  • KMID: 2272479
  • Korean J Obstet Gynecol.
  • 2004 Dec;47(12):2439-2446.
OBJECTIVE: To evaluate the effect of the epidermal growth factor (EGF) and the transforming growth factor-alpha (TGF-alpha) on the apoptosis of the rat granulosa cells. METHODS: For this study, granulosa...
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Expression of Angiogenic Growth Factor in Middle Ear Cholesteatoma

Baek MJ, Bang EK, Hwang MS, Han TH, Park SK, Eom JW, Goh EK

  • KMID: 2074507
  • Korean J Otolaryngol-Head Neck Surg.
  • 2004 Jul;47(7):617-625.
BACKGROUND AND OBJECTIVES: Angiogenesis is important both in normal and pathologic processes, including wound healing and inflammation. Because proliferating tissues require an enhanced blood supply, angiogenesis appears to be a...
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Effects of Neurotrophic Factors on the Generation of Functional Dopamine Secretory Neurons Derived from in vitro Differentiated Human Embryonic Stem Cells

Lee KS, Kim EY, Shin HA, Cho HY, Wang KC, Kim YS, Lee HT, Chung KS, Lee WD, Park S, Lim JH

  • KMID: 1891197
  • Korean J Fertil Steril.
  • 2004 Mar;31(1):19-27.
OBJECTIVE: This study was to examine the in vitro neural cell differentiation patterns of human embryonic stem (hES) cells following treatment of various neurotrophic factors [basic fibroblast growth factor (bFGF),...
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Signal Transduction of MUC5AC Expression in Airway Mucus Hypersecretory Disease

Shim JJ

BACKGROUND: Mucin synthesis in airways has been reported to be regulated by the epidermal growth factor receptor (EGFR) system. Epidermal growth factor receptor transactivation was identified as a critical element...
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Short-term Morphological and Growth Factor Changes in Rat Bladders Augmented with a Porcine Small Intestinal Submucosa

Byun SS, Kim JH, Oh JE, Kim HH, Lee ES, Lee CW

  • KMID: 2293339
  • Korean J Urol.
  • 2003 May;44(5):473-480.
PURPOSE: This study was performed to investigate the short-term changes in the morphology and growth factors after the augment of rat bladders with a porcine small intestinal submucosa (SIS). MATERIALS AND...
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Transforming Growth Factor-alpha Regulation of Insulin-like Growth Factor-II, Insulin-like Growth Factor Binding Protein-1 and 3 secretion and Epidermal Growth Factor receptor expression in human luteinized granulosa cells

Kang EH, Hong SH, Cho JS, Kim SH, Chae HD, Kim CH, Kang BM, Nam JH

  • KMID: 2270618
  • Korean J Obstet Gynecol.
  • 2002 Dec;45(12):2130-2139.
OBJECTIVE: To investigate the effects of transforming growth factor (TGF)-alpha on insulin-like growth factor (IGF)-II, insulin-like growth factor binding protein (IGFBP)-1, and 3 secretion and epidermal growth factor (EGF) receptor...
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Postnatal Development of Transforming-growth Factor-alpha and Epidermal Growth Factor Receptor-immunoreactive Neurons in the Cerebral Cortex of the Rat

Chung YY, Kim NH, Kim JJ, Moon JS, Park YL, Ryu SY, Kim HK

  • KMID: 1559310
  • Korean J Anat.
  • 2002 Aug;35(4):269-284.
Transforming growth factor-alpha (TGF-alpha ) and epidermal growth factor receptor (EGFR) immunoreactivities were examined in the cerebral cortex of the rat during postnatal development. TGF-alpha -immunoreactive cells were found at...
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Comparison of Transforming Growth Factor-alpha and Epidermal Growth Factor Expression in Melanocytic Nevi: An Immunohistochemical Study

Kang YS, Chung YY

  • KMID: 1559309
  • Korean J Anat.
  • 2002 Aug;35(4):261-268.
Transforming growth Factor-alpha(TGF-alpha) and epidermal growth factor (EGF) are polypeptides which interact with the epidermal growth factor receptor (EGFR) to produce its biological effects. In normal human tissues, its immunocytochemical...
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Expression of TGF-alpha, beta1, beta2 in Pterygial Mast cell

Kim TH, Seo SW, Song JK

  • KMID: 2206119
  • J Korean Ophthalmol Soc.
  • 2002 Jul;43(7):1261-1268.
PURPOSE: To evaluate whether TGF-alpha, beta1, beta2 are expressed in pterygial mast cell and the difference between each growth factor exists. METHODS: We prepared 10 pieces each of excised normal conjunctiva,...
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Polyamines Regulate Growth Factor-Induced Protein Phosphorylation in MCF-7 Human Breast Cancer Cells

Lee JY, Lee KH, Kim BG

  • KMID: 2134354
  • Cancer Res Treat.
  • 2002 Jun;34(3):198-204.
PURPOSE: Growth factors stimulate protein phosphorylation resulting in transmission of mitogenic signals. In breast cancer, protein kinases and their substrate proteins are importnat in cell proliferation and phathogenesis. Polymine is...
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Influence of Transforming Growth Factor-alpha on Expression of Matrix metalloproteinase-2 and Matrix metalloproteinase-9 mRNA in Mouse Embryos

Kim CH, Kim SH, Park EJ, Hong SH, Chae HD, Kang BM

  • KMID: 2262666
  • Korean J Obstet Gynecol.
  • 2002 Mar;45(3):443-449.
OBJECTIVE: To investigate the influence of transforming growth factor-alpha (TGF-alpha) on the expression of Matrix metalloproteinase-2 (MMP-2) and Matrix metalloproteinase-9 (MMP-9) mRNA in mouse embryos. MATERIALS AND METHOD: Eight-cell stage mouse...
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Immunocytochemical Localization of Transforming Growth Factor-alpha in the Forebrain of the Rat

Chung YY, Park SS, Yoon SP, Kim JJ, Moon JS, Jeong SB, Kim HS

  • KMID: 1558768
  • Korean J Anat.
  • 2001 Dec;34(6):589-602.
The distribution of Transforming growth factor-alpha (TGF-alpha) was examined in the rat forebrain by immunocytochemistry. TGF-alpha immunoreactivity was observed in the cerebral hemispheres, thalamus and hypothalamus. Neurons in the olfactory...
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An Immunohistochemical study on the Expression of EGFR, TGF-alpha and Ki-67 in the Uterine Cervical Neoplasia

Chung JK, Lee SK, Kim MK, Bae DH, Kim CJ

  • KMID: 2076228
  • Korean J Obstet Gynecol.
  • 2001 Apr;44(4):727-733.
OBJECTIVE: Cervical carcinoma of the uterus, the most common maliganacy among women in Korea, which its etiology and pathogenesis are not yet determined. Recently, since it has been found about...
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The Effect of Transforming Growth Factor-alpha on the Preimplantation Development, Implantation and Epidermal Growth Factor Receptor Expression in Mouse Embryos

Kim SH, Park EJ, Chae HD, Kim CH, Kang BM, Chang YS, Hong SH, Ju E

  • KMID: 2270087
  • Korean J Obstet Gynecol.
  • 2001 Feb;44(2):312-318.
OBJECTIVE: To investigate the influence of transforming growth factor-alpha (TGF-alpha) on preimplantation development, implantation and epidermal growth factor receptor (EGFR) expression in mouse embryos. MATERIALS AND METHODS: Eight-cell stage mouse embryos...
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Expression of Epidermal Growth Factor, Transforming Growth Factor-alpha and Epidermal Growth Factor Receptor in Human Cervical Neoplasia

Lee BH, Kwon DJ, Kim CJ, Kwon YI, Park TC, Kim JH, Lee JW, Kim DK, Namkoong S

  • KMID: 2270066
  • Korean J Obstet Gynecol.
  • 2001 Feb;44(2):273-276.
OBJECTIVE: This study seeks to define the expression of epidermal growth factor(EGF) and transforming growth factor(TGF)-alpha and epidermal growth factor receptor(EGFR), and the relationship to the tumor progression of human...
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Effect of Transforming Growth Factor-beta1 on Expressions of Epidermal Growth Factor and Transforming Growth Factor-alpha in DU145 Androgen-Independent Prostate Cancer Cells

Shin KY, Kong G, Choi HS, Lee JJ, Lee TY

  • KMID: 2292443
  • Korean J Urol.
  • 2001 Jan;42(1):40-46.
PURPOSE: This study was designed to identify the possible mechanism of insensitivity of DU145 prostate cancer cells to the transforming growth factor (TGF)-beta1-mediated growth inhibition. MATERIALS AND METHODS: DU145 cells were...
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