Korean J Med.
2012 Apr;82(4):512-515.
A Case of Lactic Acidosis Caused by Linezolid Treatment of Persistent Methicillin-Resistant Staphylococcus Aureus Bacteremia
- Affiliations
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- 1Department of Internal Medicine, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. yskim@amc.seoul.kr
- 2Department of Infectious Disease, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea.
Abstract
- Linezolid is an antibiotic in the oxazolidinone family that works as a bacterial protein synthesis inhibitor. It is used for the treatment of Gram-positive, multidrug-resistant bacteria. Adverse effects of linezolid include bone marrow suppression, peripheral or optic neuropathy, and, less commonly, lactic acidosis. Lactic acidosis usually occurs as a result of cardiopulmonary failure or sepsis, but it is sometimes caused by drugs, such as linezolid, and treatment of such lactic acidosis involves cessation of the drug. We report a case of lactic acidosis caused by the use of linezolid for the treatment of persistent methicillin-resistant Staphylococcus aureus bacteremia, which occurred after endoscopic sclerotherapy of gastic varices.
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