Korean J Med.  2012 Mar;82(3):371-373.

A Case of Linezolid-Associated Lactic Acidosis

• Lee HJ
• Choi JH
• Kim SY
• Chung KH
• Lee TW
• Ihm CG
• Moon JY

Abstract

Linezolid has been used for treatment of vancomycin-resistant Enterococcus faecium infection, nosocomial pneumonia caused by Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus or Streptococcus pneumoniae, and complicated and uncomplicated skin and skin structure infections. Lactic acidosis is an adverse effect associated with drugs, including metformin, the nucleoside reverse-transcriptase inhibitors and, rarely, linezolid. We report a case in which severe lactic acidosis developed as an adverse effect of linezolid in a 75-year-old woman who had been on linezolid for 30 days for treatment of a wound infection caused by methicillin-resistant coagulase-negative Staphylococcus. Discontinuation of linezolid and hemodialysis improved her lactic acidosis.

Keyword

Linezolid; Lactic acidosis

MeSH Terms

Acetamides
Acidosis, Lactic
Aged
Cross Infection
Enterococcus faecium
Female
Humans
Metformin
Methicillin Resistance
Methicillin-Resistant Staphylococcus aureus
Oxazolidinones
Pneumonia
Renal Dialysis
Skin
Staphylococcus
Staphylococcus aureus
Streptococcus pneumoniae
Wound Infection
Linezolid
Acetamides
Metformin
Oxazolidinones