Korean J Anesthesiol.  1998 Dec;35(6):1080-1088. 10.4097/kjae.1998.35.6.1080.

Responses of Pro-Inflammatory and Anti-Inflammatory Cytokines with Clonidine Premedication in Patients Undergoing Spinal Surgery

• Kim MH
• Kim JS
• Ahn HJ

• KMID: 2237622
• DOI: http://doi.org/10.4097/kjae.1998.35.6.1080

Abstract

BACKGROUND: As immune mediators, cytokines are thought to regulate many biological functions. Changes in cytokine response were found in stressful conditions including surgery. Our aim was to study the effects of oral clonidine premedication on the proinflammatory and antiinflammatory cytokines in patients undergoing spinal fusion.
METHODS
Thirty patients (ASA I and II) were selected and randomly assigned to one of the three groups. Group 1, 2, and 3 received no premedication, clonidine 0.15 mg and 0.3 mg orally, respectively. Blood concentrations of proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), Interleukin-1beta (IL-1beta), IL-6, and antiinflammatory cytokines IL-10, IL-13 were determined as following intervals: before induction, immediate, 1 h, 3 h and 5 h after incision. For cytokines assay, commercially available ELISA kits were used.
RESULTS
Compared to baseline values, TNF-alpha , IL-6 and IL-10 concnetrations at 3 h and 5 h after incision increased significantly in all the individual groups. IL-1beta increased significantly at 3 h and 5 h after incision in group 1 and 3, and at immediate, 1 h and 3 h after incision in group 2. At the same times sampled, TNF-alpha, IL-1beta, IL-6, IL-13 concentrations were not statistically different among three groups. However, IL-10 concentration increased significantly at 5 h after incision in group 2 and 3 compared to group 1. In addition, IL-10 level at 5 h after incision in group 2 was significantly different from group 3.
CONCLUSIONS
Oral clonidine premedication increased release of antiinflammatory cytokine IL-10 significantly during spinal fusion surgery.

Keyword

Immune response, antiinflammatory cytokines, proinflammatory cytokines; Premedication, clonidine; Surgery, spinal

MeSH Terms

Clonidine*
Cytokines*
Enzyme-Linked Immunosorbent Assay
Humans
Interleukin-10
Interleukin-13
Interleukin-1beta
Interleukin-6
Premedication*
Spinal Fusion
Tumor Necrosis Factor-alpha
Clonidine
Cytokines
Interleukin-10
Interleukin-13
Interleukin-1beta
Interleukin-6
Tumor Necrosis Factor-alpha