Korean J Dermatol.  1978 Aug;16(4):319-323.

Crural Ulcer After Accidental Application of 5 - Fluoroutacil Cream

• Lee KW
• Kim CW

Abstract

Topical fluorouracil therapy is an advanced treatment for actinic keratoses, Bowen's disease, multiple basal cell epithelioma and other precancerous skin lesions. Because of extensive and frequent use of 5-fluorouracil(5 F-U) cream, some untoward effects, mostly allergic contact dermatitis and irritation dermatitis, can be anticipated. We have experienced a case of crural ulcer after accidental application of 5 F-U cream for treating the tinea cruris at drug store. The patient was 21 year oid man who had suffered from erythema, erosion and shallow ulceration with oozing, serosanguinous discharge, buming and stinging sensation on the both groins and its adjacent area of the scrotum. The skin lesion was not well responded to topical corticosteroid but controlled by wet dressing and zinc oxide lotion within 10 days of hospitalization. At the 20th hospital day, the skin was healed with remained follicular hyperpigmentation. A few days later, the tinea cruris was confirmed by direct microsopic examination and culture. Generally, topical 5 F-U spares normal cell, while selectively destroying the more rapidly proliferating celI, but there are some possible factors to induce destruction of non-proliferating cell in the highly penetrating area The skin penetration can be different depending upon the anatomical location.

MeSH Terms

Bandages
Bites and Stings
Bowen's Disease
Carcinoma, Basal Cell
Dermatitis
Dermatitis, Allergic Contact
Erythema
Fluorouracil
Groin
Hospitalization
Humans
Hyperpigmentation
Keratosis, Actinic
Scrotum
Sensation
Skin
Tinea
Ulcer*
Zinc Oxide
Fluorouracil
Zinc Oxide