Chonnam Med J.  2008 Dec;44(3):132-136. 10.4068/cmj.2008.44.3.132.

Effects of Renewal SS-cream on the Bulbocavernosus Reflex (BCR) in Rabbits

• Tian L
• Wu YG
• Jin Z
• Zhu YC
• Qin XC
• Gong YQ
• Xin ZC

• KMID: 2172291
• DOI: http://doi.org/10.4068/cmj.2008.44.3.132

Abstract

Renewal SS-cream is a topical agent modified from the original SS-cream which is effective in the treatment of premature ejaculation. In this study, the efficacy of renewal SS-cream on premature ejaculation caused by the bulbocavernosus reflex (BCR) was investigated in rabbits. Sixty male New Zealand white rabbits (weights: 2.5~3.0 kg) were divided into 3 groups randomly. Either renewal or original SS-cream or placebo (provided by CJ Co. LTD) was topically applied to the glans penis of rabbits in a double-blind manner. The bulbocavernosus reflex (BCR) was elicited by electrical stimulation of the glans penis. The latency of BCR (BCRLT) and the amplitude of BCR (BCRAP) were recorded on an electrophysiograph (Poseidomn, Shanghai, China) before and at 10, 30 and 60 min after application of the test agents. Representative tracings of BCRLT and BCRAP were recorded and analyzed. The mean BCRLT values were significantly prolonged in post-application groups of SS-cream(R) and renewal SS-cream(R), compared with those in pre-application and placebo groups (p<0.05). There was no significant difference in efficacy between SS-cream(R) and renewal SS-cream(R) groups (p>0.05). The mean BCRAP showed decreasing tendency following application of SS-cream(R) and renewal SS-cream(R); however, they were not significantly different (p>0.05). Both of original SS-cream(R) and renewal SS-cream(R) prolonged the BCRLT after their application to the glans penis in rabbits. The results indicate that they have local desensitizing effects on the sensory receptors of the dorsal nerve of the glans penis and may help control the ejaculatory reflex in patients with premature ejaculation.

Keyword

Ejaculation; Reflex; Rabbits

MeSH Terms

Ejaculation
Electric Stimulation
Humans
Male
Penis
Premature Ejaculation
Rabbits
Reflex
Sensory Receptor Cells

Figure

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  Fig. 1 Representative tracing of bulbocavernosus reflex (BCR) responses elicited by electric stimulation at the glans penis of rabbit before and after (10, 30 and 60 min) application of renewal SS-cream® on glans penis.

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  Fig. 2 The latencies of bulbocavernosus reflex (BCRLT) changes elicited by electric stimulation at glans penis of rabbit before (pre) and 10 min, 30 min, 60 min after (post) application of test drugs on the glans penis.

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  Fig. 3 Amplitudes of bulbocavernosus reflex (BCRAP) measured after electric stimulation at glans penis of different rabbit groups before and 10, 30, 60 min after application of test drugs on the glans penis.

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