Korean Circ J.  2002 Feb;32(2):106-117. 10.4070/kcj.2002.32.2.106.

The Relationship of Coronary Arterial Lesion with Clinical Factors in Type II Diabetes

• Choi EK
• Park YB
• Oh S
• Chae IH
• Kim CH
• Sohn DW
• Oh BH
• Lee MM
• Choi YS

• KMID: 2227276
• DOI: http://doi.org/10.4070/kcj.2002.32.2.106

Abstract

BACKGROUND AND OBJECTIVES
In order to predict coronary artery disease with clinical factors in type II diabetes, we analyzed the relationship between coronary arterial lesion on coronary angiogram and clinical factors.
SUBJECTS AND METHODS
Type II diabetic patients (n=520) were selected from patients who had undergone coronary angiography (CAG) at Seoul National University Hospital. The patient group comprised 461 patients with more than 50% stenosis on CAG and the control group comprised 59 patients with normal CAG. We retrospectively reviewed the measured basic demographics, diabetes statuses, biochemical markers, echocardiographic and coronary angiographic findings.
RESULTS
In multivariate analysis, hypertension (p=0.002), smoking (p=0.003), diabetes history longer than 10 years (p=0.030), HbA 1c greater than 7.5% (p<0.001) and HDL-cholesterol level less than 40 mg/dL (p=0.010) were all found to be independent risk factors of coronary artery disease (CAD) on CAG. When the patients were divided into 3 groups according to the number of risk factors, 0 - 1, 2-3 and 4-5, the odd ratios for the second and third groups were 3.0 and 16.0, respectively, compared to that of the first group. The number of risk factors had a positive correlation with the number of diseased vessels.
CONCLUSION
In type II diabetic patients, CAD risk factors on CAG were hypertension, smoking, diabetes history longer than 10 years, HbA 1c greater than 7.5%, and HDL-cholesterol level less than 40 mg/dL. The number of risk factors was positively correlated with the presence and severity of CAD on CAG.

Keyword

Coronary arteriosclerosis; Diabetes mellitus; Risk factors

MeSH Terms

Biomarkers
Constriction, Pathologic
Coronary Angiography
Coronary Artery Disease
Demography
Diabetes Mellitus
Echocardiography
Humans
Hypertension
Multivariate Analysis
Retrospective Studies
Risk Factors
Seoul
Smoke
Smoking
Smoke