Korean Circ J.  2010 Jul;40(7):299-305. 10.4070/kcj.2010.40.7.299.

Apoptosis in Cardiovascular Diseases: Mechanism and Clinical Implications

Affiliations
  • 1Division of Cardiology, Department of Internal Medicine, Wonkwang University Medical School, Iksan, Korea.
  • 2Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. pkang@bidmc.harvard.edu

Abstract

Apoptosis is a tightly regulated, cell deletion process that plays an important role in various cardiovascular diseases, such as myocardial infarction, reperfusion injury, and heart failure. Since cardiomyocyte loss is the most important determinant of patient morbidity and mortality, fully understanding the regulatory mechanisms of apoptotic signaling is crucial. In fact, the inhibition of cardiac apoptosis holds promise as an effective therapeutic strategy for cardiovascular diseases. Caspase, a critical enzyme in the induction and execution of apoptosis, has been the main potential target for achieving anti-apoptotic therapy. Studies suggest, however, that a caspase-independent pathway may also play an important role in cardiac apoptosis, although the mechanism and potential significance of caspase-independent apoptosis in the heart remain poorly understood. Herein we discuss the role of apoptosis in various cardiovascular diseases, provide an update on current knowledge about the molecular mechanisms that govern apoptosis, and discuss the clinical implications of anti-apoptotic therapies.

Keyword

Cell death; Necrosis; Heart; Caspase; Apoptosis inducing factor

MeSH Terms

Apoptosis
Apoptosis Inducing Factor
Cardiovascular Diseases
Cell Death
Heart
Heart Failure
Humans
Myocardial Infarction
Myocytes, Cardiac
Necrosis
Reperfusion Injury
Apoptosis Inducing Factor
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