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Effect of Bevacizumab Treatment in Cerebral Radiation Necrosis : Investigation of Response Predictors in a Single-Center Experience

Lee SH, Choi JW, Kong DS, Seol HJ, Nam DH, Lee JI

Objective : Bevacizumab is a feasible option for treating cerebral radiation necrosis (RN). We investigated the clinical outcome of RN after treatment with bevacizumab and factors related to the initial...
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Efficacy and Safety of Infliximab in Intestinal Behçet’s Disease: A Multicenter, Phase 3 Study (BEGIN)

Cheon JH, Kim HS, Han DS, Kim SK, Shin SJ, Kim JS, Ye BD, Song GA, Lee Y, Kim Y, Lee Y, Kim WH, BEGIN Study Group

Background/Aims: To date, there is no prospective study that specifically investigated the efficacy of infliximab in intestinal Behçet’s disease (BD). This study evaluated the efficacy of infliximab in patients with...
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Comparison of Long-term Outcomes between Nonoperative Treatment and Vascularized Bone Graft for Kienböck Disease: A Systematic Review and Single-Arm Meta-Analysis

Park JY, Kim JK, Shin YH

Background: This systematic literature review compared long-term outcomes between nonoperative treatment and vascularized bone graft (VBG) in patients with Kienböck disease. Methods: We systematically reviewed studies on nonoperative treatment and VBG...
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Effects of remote ischemic postconditioning on hepatic injury in lipopolysaccharide-induced endotoxemic rats

Cho JD, Jung H, Lee JE, Choi EK, Kim HA, Ri HS, Kim H, Park JY, Kwak KH, Lim DG

Background: Remote ischemic postconditioning (RIPoC) is induced by several cycles of brief, reversible, mechanical blood flow occlusion, and reperfusion of the distal organs thereby protecting target organs. We investigated if...
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Comparative effectiveness of JAK inhibitors and biologic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis

Cho SK, Kim H, Song YJ, Kim HW, Nam E, Lee SS, Lee HS, Park SH, Lee YA, Park MC, Chang SH, Kim HA, Kwok SK, Kim HR, Kim HS, Yoon BY, Uhm WS, Kim YG, Kim JH, Lee J, Choi J, Sung YK

Background/Aims: We aimed to compare the effectiveness and safety of Janus kinase inhibitors (JAKi) vs. biologic disease- modifying antirheumatic drugs (bDMARD) in Korean patients with rheumatoid arthritis (RA) who had...
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Amelioration of DSS-induced colitis in mice by TNF-α-stimulated mesenchymal stem cells derived from feline adipose tissue via COX-2/PGE2 activation

Kim K, An JH, Park SM, Lim G, Seo KW, Youn HY

Background: Mesenchymal stem cells (MSCs) have been investigated as therapeutic agents for inflammatory bowel disease (IBD). Stimulation of MSCs with pro-inflammatory cytokines is an approach to enhance their immunomodulatory effects....
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Bone Biopsy Confirmed Imatinib-Induced Bone Marrow Necrosis in Patient with Gastrointestinal Tumor: A Case Report

Kim HJ

Imatinib mesylate is an effective, small-molecule, selective tyrosine kinase inhibitor, which inhibits BCR-ABL in patients with chronic myeloid leukemia, c-kit in patients with gastrointestinal tumor (GIST), and platelet-derived growth factors...
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Core decompression for early-stage avascular necrosis of the humeral head: current concepts and techniques

Scheidt MD, Aiyash S, Salazar D, Garbis N

Avascular necrosis (AVN) of the humeral head is a rare, yet detrimental complication. Left untreated, humeral head AVN frequently progresses to subchondral fracturing and articular collapse. Cases of late-stage humeral...
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Penile Glans Necrosis Following Prostatic Artery Embolization for Benign Prostatic Hyperplasia: Case Series and Review of Current Literature

Chung E

Purpose To report a case series of 6 patients with penile glans necrosis (PGN) following prostatic artery embolization (PAE) and review the current literature relating to PAE and PGN, including the...
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Silymarin attenuates escitalopram (cipralex) induced pancreatic injury in adult male albino rats: a biochemical, histological, and immunohistochemical approach

Salama RM, Tayel SG

Depression is a prevalent global problem since ages, predominately treated with SSRI. Cipralex, is an antidepressant of the SSRIs class used as a remedy for mood, depression and anxiety. Silymarin...
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A Case of Inferior Turbinate Osteonecrosis Due to Denosumab

Cho Y, Kim D, Shin JM, Park IH

In rare cases, antiresoprtive medications for osteoporosis cause osteonecrosis. Necrotic bone lesions localized at the jaw after the use of antiresorptive medications is named medicationrelated osteonecrosis of the jaw (MRONJ)....
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Tumor Habitat Analysis Using Longitudinal Physiological MRI to Predict Tumor Recurrence After Stereotactic Radiosurgery for Brain Metastasis

Lee DH, Park JE, Kim N, Park SY, Kim YH, Cho YH, Kim JH, Kim HS

Objective: It is difficult to predict the treatment response of tissue after stereotactic radiosurgery (SRS) because radiation necrosis (RN) and tumor recurrence can coexist. Our study aimed to predict tumor...
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Bronchoesophageal fistula in a patient with Crohn’s disease receiving anti-tumor necrosis factor therapy

Oh K, Choi KD, Kim HR, Shim TS, Ye BD, Yang SK, Park SH

Tuberculosis is an adverse event in patients with Crohn’s disease receiving anti-tumor necrosis factor (TNF) therapy. However, tuberculosis presenting as a bronchoesophageal fistula (BEF) is rare. We report a case...
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Protective Effect of Locally Injected Polydeoxyribonucleotide in Ischemic Murine Random Skin Flaps

Kim J, Yang J, Ku M, Im J, Lee JY, Koh YW, Choi EC, Sim NS, Kim JH

Background and Objectives This study aimed to investigate the protective effect of polydeoxyribonucleotide (PDRN) against skin flap necrosis in a murine skin flap model. Materials and Method Twenty mice with rectangular...
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Risk Factors for Surgery in Patients with Intestinal Behçet’s Disease During Anti-Tumor Necrosis Factor-Alpha Therapy

Han SJ, Kang EA, Park J, Park SJ, Park JJ, Kim TI, Kim WH, Cheon JH

Purpose: Behçet’s disease (BD) is a chronic inflammatory immune-mediated disease involving multiorgan systems. Gastrointestinal (GI) manifestations of BD include abdominal pain, vomiting, GI bleeding, fistula formation, obstruction, and perforation that...
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The mechanism of human neural stem cell secretomes improves neuropathic pain and locomotor function in spinal cord injury rat models: through antioxidant, anti-inflammatory, anti-matrix degradation, and neurotrophic activities

Semita IN, Utomo DN, Suroto H, Sudiana IK, Gandi P

Background: Globally, spinal cord injury (SCI) results in a big burden, including 90% suffering permanent disability, and 60%–69% experiencing neuropathic pain. The main causes are oxidative stress, inflammation, and degeneration....
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Risk of cancer, cardiovascular disease, thromboembolism, and mortality in patients with rheumatoid arthritis receiving Janus kinase inhibitors: a real-world retrospective observational study using Korean health insurance data

Min HK, Kim H, Jeong HJ, Kim SH, Kim HR, Lee SH, Lee K, Shin SA, Park JH

OBJECTIVES: This study investigated whether Janus kinase inhibitors (JAKis) raise the risk of cardiovascular disease (CVD), venous thromboembolism (VTE), and cancer in patients with rheumatoid arthritis (RA). METHODS: We conducted a...
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Avascular Necrosis of the Capitate: MRI and Surgical Decision-Making of Two Case Reports

Yoo H, Ahn KS, Lee HG, Kang CH

Avascular necrosis (AVN) is a rare disease occurring in the capitate of the wrist which is the third most common site of AVN among carpal bones. There are few reports...
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Gastric necrosis after gastric artery embolization in a patient with blunt abdominal trauma: a case report

Kim GH, Park SJ, Park CI

Gastric artery bleeding after blunt trauma is rare. In such cases, if vital signs are stable, angiographic embolization may be performed. Although gastric artery embolization is known to be safe...
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Trends in Surgical Treatment of Femoral Head Osteonecrosis in South Korea: An Analysis Using Nationwide Claims Database

Park JW, Kim HS, Park S, Kim SH, Lee YK, Koo KH

Background: Osteonecrosis of the femoral head (ONFH) involves young or middle-aged adults, and its incidence is increasing along with increasing use of steroids in the management of organ transplantation and...
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