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Effect of apoptosis on G361 cells by Cimicifuga rhizoma extract

Choi BB, Kim GC, Hong JW, Park SR

OBJECTIVES: To investigate whether the cytotoxic effect of Cimicifuga rhizoma extract is associated with cell death in the human keratinocyte (HaCaT) and human melanoma cell lines (G361). METHODS: Apoptosis induced by...
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Induction of Melanoma Cell-Selective Apoptosis Using Anti-HER2 Antibody-Conjugated Gold Nanoparticles

Jeon HJ, Choi BB, Park KH, Hwang DS, Kim UK, Kim GC

PURPOSE: This study was conducted to verify the induction and mechanism of selective apoptosis in G361 melanoma cells using anti-HER2 antibody-conjugated gold nanoparticles (GNP-HER2). MATERIALS AND METHODS: Following GNP-HER2 treatment of...
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Role of Annexin A5 on Mitochondria-Dependent Apoptosis Induced by Tetramethoxystilbene in Human Breast Cancer Cells

Hong M, Park N, Chun YJ

We have previously shown that 2,4,3',5'-tetramethoxystilbene (TMS), a trans-stilbene analogue, induces apoptosis in human cancer cells. However, the detailed mechanisms of mitochondria-dependent apoptosis induced by TMS are not fully understood....
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Induction of Selective Cell Death of Oral Squamous Carcinoma Cells by Integrin alpha2 Antibody and EGFR Antibody

Choi YS, Kim GC, Yoon S, Hwang DS, Kim CH, Jeon YC, Byun JH, Shin SH, Kim UK

  • KMID: 2004433
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2013 May;35(3):143-154.
PURPOSE: This study was to find efficacy of integrin alpha2 (alpha2) and epidermal growth factor receptor (EGFR) as tumor marker of oral squamous cell carcinoma (SCC) and clarify the selective...
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Evidence of early involvement of apoptosis inducing factor-induced neuronal death in Alzheimer brain

Lee JH, Cheon YH, Woo RS, Song DY, Moon C, Baik TK

Apoptosis inducing factor (AIF) has been proposed to act as a putative reactive oxygen species scavenger in mitochondria. When apoptotic cell death is triggered, AIF translocates to the nucleus, where...
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Protective Effect of Minocycline Against Cisplatin-induced Ototoxicity

Lee CK, Shin JI, Cho YS

  • KMID: 2166447
  • Clin Exp Otorhinolaryngol.
  • 2011 Jun;4(2):77-82.
OBJECTIVES: Cisplatin, a widely used chemotherapeutic agent, has serious side effects, including nephrotoxicity and ototoxicity. Minocycline is a semisynthetic second-generation tetracycline that exerts anti-inflammatory and neuroprotective effects. The purpose of...
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Apoptosis in Cardiovascular Diseases: Mechanism and Clinical Implications

Kim NH, Kang PM

Apoptosis is a tightly regulated, cell deletion process that plays an important role in various cardiovascular diseases, such as myocardial infarction, reperfusion injury, and heart failure. Since cardiomyocyte loss is...
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Temporal Characteristics of Cytosolic Translocation of Mitochondrial Proteins in Permanent Distal Middle Cerebral Artery Occlusion Model of Rats

Shin BW, Sung JH, Hong JT, Son BC, Lee SW, Park CK

  • KMID: 2118517
  • J Korean Neurosurg Soc.
  • 2007 May;41(5):306-313.
OBJECTIVE: In permanent distal middle cerebral artery occlusion (pdMCAO) model of rats, the temporal order of subcellular translocation is not fully understood yet. We studied translocation sequence of cytochrome c...
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Effects of alpha-Lipoic Acid on Apoptotic Cell Death in Rat Hippocampus Following Transient Forebrain Ischemia-reperfusion Injury

Ahn HC, Song JH, Kim KS, Yoo SJ

  • KMID: 2331506
  • J Korean Soc Emerg Med.
  • 2007 Apr;18(2):134-142.
PURPOSE: The purpose of this study was to evaluate effect of alpha-lipoic acid on apoptotic cell death in rat hippocampal neuron following transient forebrain ischemia-reperfusion (I/R) injury. METHODS: The four-vessel occlusion...
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Arsenic Trioxide Induces A poptosis in Human Colorectal Adenocarcinoma HT-29 Cells Through ROS

Cha Y, Park DW, Lee CH, Baek SH, Kim SY, Kim JR, Kim JH

  • KMID: 2166094
  • Cancer Res Treat.
  • 2006 Feb;38(1):54-60.
PURPOSE: Treatment with arsenic trioxide (As2O3) results in a wide range of cellular effects that includes induction of apoptosis, inhibition of cell growth, promotion or inhibition of cellular differentiation, and...
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Sulindac-induced Apoptosis without Oligonucleosomal DNA Fragmentation in HT-29 Cells: Its Special References to Mitochondrial Pathway

Park KJ, Kwon Y, Kim SH, Kim MC, Choi HJ, Kim YH, Cho SH, Jung GJ, Kim SH, Kwon HC

  • KMID: 1566533
  • J Korean Soc Coloproctol.
  • 2004 Aug;20(4):191-198.
PURPOSE: This study was undertaken to reveal the molecular mechanism underlying sulindac-induced apoptosis in the human colon cancer cell line HT-29 (mutant p53). METHODS: Apoptosis was determined by using Hoechst...
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Running Title: Apoptotic Effect of Mycolactone in SCC15 Cells

Kim JW, Song JC, Lee HK, Lee TY

  • KMID: 1961184
  • J Korean Assoc Oral Maxillofac Surg.
  • 2001 Dec;27(6):511-518.
The effect of mycolactone, a recently reported apoptosis-inducing factor, was investigated in SCC15 oral squamous cell carcinoma (OSCC) cell line. Mycolactone rapidly induced cell death in OSCC cells in 2days,...
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