J Menopausal Med.  2016 Apr;22(1):6-8. 10.6118/jmm.2016.22.1.6.

The Relevance of Women's Diseases, Jun Activation-domain Binding Protein 1 (JAB1) and p27(kip1)

  • 1Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University, Asan, Korea.
  • 2Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, Korea. heeobgy@schmc.ac.kr


The Jun activation-domain binding protein 1 (Jab1) recognize a potential coactivator of activator protein 1 (AP-1) such as c-fos, c-jun transcription factor and the fifth subunit of the COP9 signalosome complex. Also, Jab1 activate the c-jun gene resulted cell proliferation. Not only a powerful tumor suppressor but also regulator of apoptosis negative cdk inhibitor p27(kip1) are involved in the cell cycle. This is Jab1 and p27(kip1) interact with each other, Jab1 accelerate p27(kip1) from nuclear to cytoplasm through ubiquitin/proteasome pathway. However, information about the relationship between Jab1 and p27(kip1) is not known much. Taken together, the results of this study identify function and structure of Jab1 and p27(kip1) were described in a recent article on the basis of relevant. Besides Jab1 and p27(kip1) will organize the relationship between the disease and women.


Breast neoplasms; Cyclin-dependent kinase inhibitor p27; Endometriosis; Ovarian neoplasms

MeSH Terms

Breast Neoplasms
Carrier Proteins*
Cell Cycle
Cell Proliferation
Cyclin-Dependent Kinase Inhibitor p27
Genes, jun
Ovarian Neoplasms
Transcription Factor AP-1
Transcription Factors
Carrier Proteins
Cyclin-Dependent Kinase Inhibitor p27
Transcription Factor AP-1
Transcription Factors


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