- The Heterochromatin-1 Phosphorylation Contributes to TPA-Induced AP-1 Expression
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Choi WJ
- KMID: 2170624
- Biomol Ther.
- 2014 Jul;22(4):308-313.
Activator protein-1 (AP-1) is an inducible transcription factor that contributes to the generation of chronic inflammation in response to oxidative and electrophilic stress. Previous studies have demonstrated that the PI3K/Akt1... -
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- Effects of dopamine and haloperidol on morphine-induced CREB and AP-1 DNA binding activities in differentiated SH-SY5Y human neuroblastoma cells
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Kim SK, Kwon GY
- KMID: 2071825
- Korean J Physiol Pharmacol.
- 1998 Dec;2(6):671-676.
In the present study, we first examined whether the changes in the DNA binding activities of the transcription factors, cAMP response element binding protein (CREB) and activator protein-1 (AP-1) mediate the long-term effects... -
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- Transcription Factors in the Cellular Signaling Network as Prime Targets of Chemopreventive Phytochemicals
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Surh YJ
- KMID: 1804561
- Cancer Res Treat.
- 2004 Oct;36(5):275-286.
Accumulating evidence from epidemiologic and laboratory studies support an inverse relationship between a regular consumption of fruits and vegetables and the risk of specific cancers. Numerous phytochemicals derived from edible... -
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- The Effect of All-Trans-Retinoic Acid and Ursolic Acid on the Ultraviolet A Radiation Induced AP-1 (Fos/Jun) Activity in Cultured Human Dermal Fibroblasts
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Kim HC, Yang JS, Chae YS, Suh KS, Kim ST
- KMID: 2425604
- Korean J Dermatol.
- 1997 Dec;35(6):1136-1142.
BACKGROUND: Recently, UVB irradiation was found to activate AP-1, which is known to be a major enhancer factor of the collagenase gene. However, tbe effect of UVA irradiation on the... -
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- The Effect of an AP-1 decoy on Collagen Synthesis in Wound Healing on Rat Skin: The use of Gene Therapy to Minimise Scarring
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Park SJ, Lee KS
- KMID: 2302636
- Korean J Dermatol.
- 2005 Apr;43(4):435-441.
BACKGROUND: The wound healing process is composed of inflammation, cellular growth, migration, angiogenesis and an extracellular matrix composition. In this process, fibroblasts proliferate but leave scarring due to their excessive... -
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- Cooperative effect of Alternaria and rhinovirus on the activation of nasal polyp epithelial cells
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Shin SH, Ye MK, Jeon BG, Jang YJ
- KMID: 2132060
- J Rhinol.
- 2012 Nov;19(2):112-118.
BACKGROUND AND OBJECTIVES: The nasal epithelium is the first barrier encountered by airborne allergens and is an active participant in airway inflammation. The aim of this study was to determine... -
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- Luteolin and luteolin-7-O-glucoside inhibit lipopolysaccharide-induced inflammatory responses through modulation of NF-kappaB/AP-1/PI3K-Akt signaling cascades in RAW 264.7 cells
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Park CM, Song YS
- KMID: 2313690
- Nutr Res Pract.
- 2013 Dec;7(6):423-429.
Luteolin is a flavonoid found in abundance in celery, green pepper, and dandelions. Previous studies have shown that luteolin is an anti-inflammatory and anti-oxidative agent. In this study, the anti-inflammatory... -
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- The Relevance of Women's Diseases, Jun Activation-domain Binding Protein 1 (JAB1) and p27(kip1)
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Kim M, Kim TH, Lee HH
- KMID: 2200913
- J Menopausal Med.
- 2016 Apr;22(1):6-8.
- doi: 10.6118/jmm.2016.22.1.6
The Jun activation-domain binding protein 1 (Jab1) recognize a potential coactivator of activator protein 1 (AP-1) such as c-fos, c-jun transcription factor and the fifth subunit of the COP9 signalosome... -
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- PDTC Inhibits TNF-alpha-Induced Apoptosis in MC3T3E1 Cells
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Chae HJ, Bae J, Chae SW
- KMID: 2285287
- Korean J Physiol Pharmacol.
- 2003 Aug;7(4):199-206.
Osteoblasts are affected by TNF-alpha overproduction by immune cells during inflammation. It has been suggested that functional NF-kappaB sites are involved in TNF-alpha-induced bone resorption. Thus, we explored the effect... -
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- Engagement of CD99 Reduces AP-1 Activity by Inducing BATF in the Human Multiple Myeloma Cell Line RPMI8226
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Gil M, Pak HK, Park SJ, Lee AN, Park YS, Lee H, Lee H, Kim KE, Lee KJ, Yoon DH, Chung YS, Park CS
- KMID: 2150855
- Immune Netw.
- 2015 Oct;15(5):260-267.
- doi: 10.4110/in.2015.15.5.260
CD99 signaling is crucial to a diverse range of biological functions including survival and proliferation. CD99 engagement is reported to augment activator protein-1 (AP-1) activity through mitogen-activated protein (MAP) kinase... -
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- STP-A11, an oncoprotein of Herpesvirus saimiri augments both NF-kappaB and AP-1 transcription activity through TRAF6
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Jeong S, Cho IR, An WG, Jhun BH, Lee BS, Park K, Chung YH
- KMID: 1103681
- Exp Mol Med.
- 2007 Feb;39(1):56-64.
Herpesvirus saimiri (HVS), a member of the gamma-herpesvirus family, encodes an oncoprotein called Saimiri Transforming Protein (STP) which is required for lymphoma induction in non-human primates. However, a detailed mechanism... -
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- Gliotoxin induces the Apoptosis in HL-60 Cells
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Chung HT, Park RK, Choi YK, Lee SR, Kim YH, Cho KH, Jang YW
- KMID: 1557245
- Korean J Immunol.
- 1998 Dec;20(4):397-403.
Many fungi including Penicillium, Aspergillus, Gliocladium, and Thermoascus produce an epipolythiodioxopiperazine class of fungal metabolite, gliotoxin, which contirbutes the pathogenesis of fungal infection as an immunomodulator and cytotoxic agent. This... -
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- Changes of AP-1 Binding Activities in Rat Brain by Electroconvulsive Shock
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Joo YH, Ahn YM, Kang UG, Koo YJ, Kim YS
- KMID: 2340872
- J Korean Neuropsychiatr Assoc.
- 2003 Sep;42(5):544-552.
OBJECTIVES: ECS could have therapeutic effects on psychiatric illnesses by inducing IEGs, which in turn regulates expression of their target genes. We observed AP-1 binding activity and identified AP-1 binding... -
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- Alteration of PKC, PKC theta, NF-kappa B and AP-1 in Ischemic-reperfused Soleus Muscle of Rat with Ischemic Preconditioning
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Kim TS, Kim JH, Kim KW
- KMID: 1848289
- J Korean Orthop Res Soc.
- 2004 Oct;7(2):184-190.
PURPOSE: This study was designed to examine the expression patterns of PKC, PKC theta which is a house-keeping member of PKC family in the skeletal muscle, and two redox sensitive... -
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- Alterations of PKC theta, NF-kappa B, and AP-1 in Ischemic-reperfused Tibialis Anterior and Soleus Muscles of Rats
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Seo YK, Jin CZ, Jun SK, Kim SB, Yoon YH, Park JJ, Paik DJ
- KMID: 1512991
- Korean J Phys Anthropol.
- 2006 Mar;19(1):61-71.
Ischemic-reperfusion injury of skeletal muscles takes place in the phase of reperfusion and induces cellular damages through activating various transcription factors and genes, which initiate signal transduction. The purpose of... -
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- Role of the Nuclear Transcription Factor NF-kappa B Caused by Acute Hypoxia in the Heart
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Joo CU, Juhng WS, Kim JC, Yi HK
- KMID: 2207175
- J Korean Pediatr Soc.
- 2002 Sep;45(9):1106-1113.
PURPOSE: Nuclear factor-kappa B(NF-kappa B) is now recognized as playing a potential role in programmed cell death and the adaptive response to various stress. Cellular hypoxia is a primary manifestation... -
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- The Effect of UVB on the NF-kB and AP-1 Activity in Cultured Human Keratinocytes and Fibroblasts
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Koo BS, Ryoo YW, Lee KS
- KMID: 2303452
- Korean J Dermatol.
- 1997 Jun;35(3):411-417.
BACKGROUND: Ultraviolet B(UVB) light, which can cause severe damage like induction and promotion of cancer, cutaneous inflammation and immunosuppression, represents one of the most important environmental impacts for humans. Keratinocytes... -
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- Growth Regulation of Ovarian Cancer Cells through the Inactivation of AP-1 by Retinoid Derivatives
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Koh YM, Park JS, Namkoong S, Lee SY, Kim SA, Hong KJ, Um SJ
- KMID: 2329189
- J Korean Cancer Assoc.
- 2000 Dec;32(6):1043-1049.
PURPOSE: The growth regulatory effect of retinoid derivatives could be mediated by the transcriptional inactivation of AP-1 oncogenic transcription factor. By using ovarian cancer cell lines we were to investigate... -
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- Effects of Multiple Cyclic Episodes with Short Ischemia and Reperfusion on the Distribution of NF-kappa B, AP-1, Bcl-2, and Bax in Rectus Femoris Muscles of Rats
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Seo YK, Paik DJ, Nam YS, Kweon TH, Kim TS
- KMID: 2283202
- Korean J Phys Anthropol.
- 2005 Mar;18(1):45-55.
The present study was designed to observe the expression patterns of NF-kappa B and AP-1, redox-sensitive transcription factors, and Bcl-2 and Bax, apoptosis repressing and promoting factors, respectively, upon repetitive... -
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- Activation of NF-κB and AP-1 Mediates Hyperproliferation by Inducing β-Catenin and c-Myc in Helicobacter pylori-Infected Gastric Epithelial Cells
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Byun E, Park B, Lim JW, Kim H
- KMID: 2374084
- Yonsei Med J.
- 2016 May;57(3):647-651.
- doi: 10.3349/ymj.2016.57.3.647
PURPOSE: In the gastric mucosa of Helicobacter pylori (H. pylori)-infected patients with gastritis or adenocarcinoma, proliferation of gastric epithelial cells is increased. Hyperproliferation is related to induction of oncogenes, such... -
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