J Korean Med Sci.  2010 Oct;25(10):1438-1442. 10.3346/jkms.2010.25.10.1438.

Clinicopathological Significance of Expression of Tspan-1, Jab1 and p27 in Human Hepatocellular Carcinoma

• Chen L
• Yuan D
• Wang GL
• Wang Y
• Wu YY
• Zhu J

• KMID: 2157846
• DOI: http://doi.org/10.3346/jkms.2010.25.10.1438

Abstract

The aim of this study was to investigate the expression of Tspan-1, Jab1 and p27 in human hepatocellular carcinoma (HCC) and their clinicopathological significance. The expression of Tspan-1, Jab1 and p27 was detected in HCC tissues, the tissues around cancer (76 cases), and the normal tissues around the liver hemangiomas (10 cases). The overexpression of Tspan-1 and Jab1 was found in HCC tissues, positively correlated with clinical stage and negatively correlated with survival rate. The expression of p27 was found inversely linked to which of Tspan-1 and Jab1. In conclusion, the expression of Tspan-1, Jab1 and p27 is significantly associated with development of HCC. Overexpression of Tspan-1 and Jab1 suggests poor prognosis but overexpression of p27 may expect good prognosis for patients with HCC.

Keyword

Carcinoma, Hepatocellular; Tspan-1; Jab1; p27; Prognosis

MeSH Terms

Adult
Aged
Carcinoma, Hepatocellular/metabolism/mortality/*pathology
Cyclin-Dependent Kinase Inhibitor p27/*metabolism
Female
Humans
Intracellular Signaling Peptides and Proteins/*metabolism
Liver Neoplasms/metabolism/mortality/*pathology
Male
Membrane Proteins/*metabolism
Middle Aged
Peptide Hydrolases/*metabolism
Prognosis
Survival Rate