J Korean Acad Fam Med.
2004 Oct;25(10):746-753.
The Relation of Nonalcoholic Fatty Liver Disease to Metabolic Syndrome
- Affiliations
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- 1Department of Family Medicine, Konyang University Hospital, Korea. jeehyunkang@yahoo.co.kr
- 2Department of Family Medicine, Ewha Womans University Hospital, Korea.
- 3Department of Family Medicine, Soonchunhyang University Hospital, Korea.
Abstract
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BACKGROUND: The aim of this study was to elucidate the relationship between nonalcoholic fatty liver disease diagnosed by ultrasonography and the metabolic syndrome defined by NCEP-ATP III criteria.
METHODS
Sixty-nine adult male subjects with negligible alcohol consumption underwent an anthropometric and laboratory investigation. The ultrasound scan of the liver was performed to determine the presence and the severity of nonalcoholic fatty liver disease.
RESULTS
Nonalcoholic fatty liver disease was diagnosed in 36 cases by ultrasound scan. According to the severity of nonalcoholic fatty liver, triglyceride, HDL- cholesterol, alanine aminotransferase, aspartate aminotrasnferase, fasting insulin level, HOMA-IR, and obesity related variables (body mass index, percent body fat, waist circumference) showed a significant difference. The independent variables which account for the severity of nonalcoholic fatty liver disease was waist circumference, and alanine aminotransferase which is a predictor of nonalcoholic steatohepatitis. The prevalence of metabolic syndrome was 41% vs 6.1% in nonalcoholic fatty liver group vs control group, respectively, and the odds ratio was 11.1 (95% CI 2.29~53.6). The prevalence of nonalcoholic fatty liver was increased with increasing the number of features of metabolic syndrome.
CONCLUSION
Nonalcoholic fatty liver disease was closely related to the metabolic syndrome and the severity classification of nonalcoholic fatty liver by ultrasound scan could be useful to predict of the severity of insulin resistance, and the risk of nonalcoholic steatohepatitis.
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