J Korean Cancer Assoc.  1998 Oct;30(5):970-979.

The Expression of TGF-beta1 and TGF-beta2 in Prostatic Carcinoma

• Kim KK
• Kim JR
• Kim DH
• Jang TJ
• Lee JI
• Lee KS

Abstract

Transfonning growth factor-beta (TGP-beta) is a multipotent growth factor affecting development, homeostasis, and tissue repair. We evaluate the significance of the expression of TGF-beta1 and TGF-beta2 and correlation with prognostic factors in prostate cancer.
MATERIALS AND METHODS
In order to investigate the expression of TGF-beta1 and TGF-beta2, we analyzed Immunohistochemical staining from paraffin blocks of 22 cases of the prostate carcinoma and adjacent normal prostate.
RESULTS
The expressions of TGF-beta1 and TGF-beta2 were noted in the cytoplasm of tumor cells, normal epithelial cells and stroma. The staining intensity and areas were examined and scored from 0 to 5. The TGF-beta1 staining scores of the tumor cells were higher than that of the adjacent normal epithelial cells (p=0.001). The TGF-beta2 staining scores of the tumor cells were also higher than that of the adjacent normal epithelial cells (p=0.003). However, there were no correlation between tumor surrounding stroma and normal stroma in TGF-beta1 and TGF-beta2 staining scores. The serum PSA level, the clinical stage, the Gleason score and the lymph node metastasis of the tumor did not correlated with the staining score of TGF-beta1 and TGF-beta2.
CONCLUSION
These results indicate that the prostatic cancer was associated with alteration of TGF-beta1 and TGF-beta2 expression by prostatic epithelial cells which play a role in prostatic carcinogenesis.

Keyword

Prostate; Carcinoma; TGF-beta1; TGF-beta2

MeSH Terms

Carcinogenesis
Cytoplasm
Epithelial Cells
Homeostasis
Lymph Nodes
Neoplasm Grading
Neoplasm Metastasis
Paraffin
Prostate
Prostatic Neoplasms
Transforming Growth Factor beta1*
Transforming Growth Factor beta2*
Paraffin
Transforming Growth Factor beta1
Transforming Growth Factor beta2