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Malignant transformation in a Breast Adenomyoepithelioma Caused by Amplification of c-MYC: A Common pathway to Cancer in a Rare Entity

Febres-Aldana CA, Mejia-Mejia O, Krishnamurthy K, Mesko T, Poppiti R

Breast adenomyoepitheliomas are composed of a biphasic proliferation of myoepithelial cells around small epithelial-lined spaces. Due to the rarity of adenomyoepitheliomas, the molecular data describing them are limited. Adenomyoepitheliomas are...
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Expression of Histo-blood Group Antigens in Tumor and Adjacent Normal Breast Tissues as Prognostic Markers of Breast Carcinoma

Zouine S, Marnissi F, Otmani N, Bennani Othmani M, Zaid N, Kojok K, Zaid Y, Tahiri Jouti N, Habti N

PURPOSE: Aberrant glycosylation of the histo-blood group antigens (including the angina bullosa haemorrhagica [ABH]) is often observed during malignant transformation in most types of carcinomas. Data concerning their ethnic distributions...
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Cellular Senescence in Arterial Diseases

Shimizu I, Minamino T

Cell-proliferation potency is limited, as cells cannot proceed through the cell cycle continually. Instead, they eventually show an irreversible arrest of proliferation, commonly referred to as cellular senescence. Following the...
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Chimeric Antigen Receptor T Cell Therapy: A Novel Modality for Immune Modulation

Yoon S, Eom GH

Cancer remains a leading cause of death, despite multimodal treatment approaches. Even in patients with a healthy immune response, cancer cells can escape the immune system during tumorigenesis. Cancer cells...
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Scavenger Receptor Class A to E Involved in Various Cancers

Ryu S, Howland A, Song B, Youn C, Song PI

Scavenger receptors typically bind to multiple ligands on a cell surface, including endogenous and modified host-derived molecules and microbial pathogens. They promote the elimination of degraded or harmful substances such...
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Curcumin Inhibits the Proliferation, Migration, Invasion, and Apoptosis of Diffuse Large B-Cell Lymphoma Cell Line by Regulating MiR-21/VHL Axis

Chen L, Zhan CZ, Wang T, You H, Yao R

PURPOSE: Curcumin exerts its anti-cancer effects, partly by targeting special microRNAs, in human cancers. MiR-21 is a key oncomir in carcinogenesis of multiple human cancers. Here, we aimed to further...
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Epidemiology of and Risk Factors for Esophageal Cancer in Korea

Jung HK

Esophageal cancer is an aggressive malignant tumor with a poor prognosis because of its typically advanced stage at diagnosis and treatment-related morbidity and mortality. Of the two major subtypes, esophageal...
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A Putative Adverse Outcome Pathway Relevant to Carcinogenicity Induced by Sulfuric Acid in Strong Inorganic Acid Mists

Yang JH, Koedrith P, Kang DS, Kee NK, Jung JH, Lee CM, Ahn YS, Seo YR

Based on epidemiological studies, an International Agency for Research on Cancer Working Group determined that strong inorganic acid mists containing sulfuric acid are carcinogenic to human even though, sulfuric acid,...
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Immunohistochemical Study of Fas/Fas-ligand and Cadherin Expression in Basal Cell Carcinoma in Sun-Exposed and Sun-Protected Areas

Kim JH, Suh HS, Choi YS

  • KMID: 2465949
  • Korean J Dermatol.
  • 2019 Sep;57(8):425-432.
BACKGROUND: UV radiation is the most important risk factor in the development of basal cell carcinoma (BCC). However, the association between tumorigenesis and the progression of BCC and UV exposure...
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Induction of cell deathin early developmental phase of zebrafish treated with diethylnitrosamine

Kang JS

The purpose of this study was to investigate diethylnitrosamine (DEN)-induced liver damage in zebrafish. Zebrafish larvae were divided into five groups after seventy-two hours fertilization: group 1 (G1) as control,...
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Identification of neoantigens derived from alternative splicing and RNA modification

Park J, Chung YJ

The acquisition of somatic mutations is the most common event in cancer. Neoantigens expressed from genes with mutations acquired during carcinogenesis can be tumor-specific. Since the immune system recognizes tumor-specific...
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Clinicopathological Characterization and Prognostic Implication of SMAD4 Expression in Colorectal Carcinoma

Yoo SY, Lee JA, Shin Y, Cho NY, Bae JM, Kang GH

BACKGROUND: SMAD family member 4 (SMAD4) has gained attention as a promising prognostic factor of colorectal cancer (CRC) as well as a key molecule to understand the tumorigenesis and progression...
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Biomarkers for Evaluating the Inflammation Status in Patients with Cancer

Guner A, Kim HI

Inflammation can be a causative factor for carcinogenesis or can result from a consequence of cancer progression. Moreover, cancer therapeutic interventions can also induce an inflammatory response. Various inflammatory parameters...
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A Disintegrin and Metalloproteinase 8 as a Potential Blood Biomarker for Early Diagnosis of Gastric Cancer

Chung HW, Kim JJ, Choi JI, Lee HR, Lim JB

PURPOSE: We aimed to evaluate the clinical significance of a disintegrin and metalloproteinase 8 (ADAM 8) as a potential blood biomarker for gastric cancer (GC). MATERIALS AND METHODS: Blood ADAM 8...
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Mammary Paget's Disease of the Nipple: Relatively Common but Still Unknown to Many

Ooi PS, Draman N, Yusoff SS, Zain WZ, Ganasagaran D, Chua HH

Mammary Paget's disease is clinically defined as skin inflammation of the nipple area and is an adenocarcinoma of the epidermis of the nipple. The pathogenesis of mammary Paget's disease is...
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Association of visceral adiposity and insulin resistance with colorectal adenoma and colorectal cancer

Jung IS, Shin CM, Park SJ, Park YS, Yoon H, Jo HJ, Kim N, Lee DH

BACKGROUND/AIMS: To examine whether visceral adiposity serves as a risk factor for colorectal cancer (CRC) and colorectal adenomas. METHODS: Two hundred healthy subjects, 200 patients with colorectal adenoma, and 151 patients...
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Association between Expression of 8-OHdG and Cigarette Smoking in Non-small Cell Lung Cancer

An AR, Kim KM, Park HS, Jang KY, Moon WS, Kang MJ, Lee YC, Kim JH, Chae HJ, Chung MJ

BACKGROUND: Exposure to cigarette smoking (CS) is a major risk factor for the development of lung cancer. CS is known to cause oxidative DNA damage and mutation of tumor-related genes,...
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Complications of polyacrylamide hydrogel injection for breast augmentation: A case report and literature review

Ku I, Park JU

Polyacrylamide hydrogel (PAAG) was developed in the 1980s as an injectable filler for breast augmentation and tissue contour improvement, but its potential risk for oncogenesis and the frequent occurrence of...
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Family with Sequence Similarity 83 Member H Promotes the Viability and Metastasis of Cervical Cancer Cells and Indicates a Poor Prognosis

Chen C, Li HF, Hu YJ, Jiang MJ, Liu QS, Zhou J

PURPOSE: Family with sequence similarity 83 member H (FAM83H) plays key roles in tumorigenesis. However, the specific roles of FAM83H in cervical cancer (CC) have not been well studied. MATERIALS AND...
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Human papillomavirus genotype-specific risk in cervical carcinogenesis

So KA, Lee IH, Lee KH, Hong SR, Kim YJ, Seo HH, Kim TJ

OBJECTIVE: To evaluate the risk of genotype-specific human papillomavirus (HPV) infections for the spectrum of cervical carcinogenesis and the distribution of HPV types according to age and different cervical lesions METHODS:...
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