- Shen-Kang protects against tacrolimus-induced renal injury
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Zhang LY, Jin J, Luo K, Piao SG, Zheng HL, Jin JZ, Lim SW, Choi BS, Yang CW, Li C
- KMID: 2457031
- Korean J Intern Med.
- 2019 Sep;34(5):1078-1090.
- doi: 10.3904/kjim.2017.276
BACKGROUND/AIMS: Evidence suggests that Shen-Kang (SK), a traditional Chinese herbal medicine, protects against various types of renal injury. In this study, we evaluated whether SK treatment confers renoprotection in a... -
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- Hypoxia-Inducible Factor 1α Regulates the Transforming Growth Factor β1/SMAD Family Member 3 Pathway to Promote Breast Cancer Progression
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Peng J, Wang X, Ran L, Song J, Luo R, Wang Y
- KMID: 2421366
- J Breast Cancer.
- 2018 Sep;21(3):259-266.
- doi: 10.4048/jbc.2018.21.e42
PURPOSE: The transforming growth factor β1 (TGF-β1)/SMAD family member 3 (SMAD3) pathway, and hypoxia-inducible factor 1α (HIF-1α) are two key players in various types of malignancies including breast cancer. The... -
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- Role of the transforming growth factor (TGF)-β1 and TGF-β1 signaling pathway on the pathophysiology of respiratory pneumococcal infections
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Andrade MJ, Lim JH
- KMID: 2400349
- Yeungnam Univ J Med.
- 2017 Dec;34(2):149-160.
- doi: 10.12701/yujm.2017.34.2.149
Streptococcus pneumoniae, pneumococcus, is the most common cause of community-acquired pneumonia (CAP). CAP is an important infectious disease with high morbidity and mortality, and it is still one of the... -
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- Immune Tolerance of Human Dental Pulp-Derived Mesenchymal Stem Cells Mediated by CD4âºCD25âºFoxP3⺠Regulatory T-Cells and Induced by TGF-β1 and IL-10
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Hong JW, Lim JH, Chung CJ, Kang TJ, Kim TY, Kim YS, Roh TS, Lew DH
- KMID: 2418942
- Yonsei Med J.
- 2017 Sep;58(5):1031-1039.
- doi: 10.3349/ymj.2017.58.5.1031
PURPOSE: Most studies on immune tolerance of mesenchymal stem cells (MSCs) have been performed using MSCs derived from bone marrow, cord blood, or adipose tissue. MSCs also exist in the... -
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- Inhibitors of DNA methylation support TGF-β1-induced IL11 expression in gingival fibroblasts
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Sufaru IG, Beikircher G, Weinhaeusel A, Gruber R
- KMID: 2377741
- J Periodontal Implant Sci.
- 2017 Apr;47(2):66-76.
- doi: 10.5051/jpis.2017.47.2.66
PURPOSE: Oral wound healing requires gingival fibroblasts to respond to local growth factors. Epigenetic silencing through DNA methylation can potentially decrease the responsiveness of gingival fibroblasts to local growth factors.... -
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- Relaxin Modulates the Expression of MMPs and TIMPs in Fibroblasts of Patients with Carpal Tunnel Syndrome
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Kang YM, Lee HM, Moon SH, Kang H, Choi YR
- KMID: 2427132
- Yonsei Med J.
- 2017 Mar;58(2):415-422.
- doi: 10.3349/ymj.2017.58.2.415
PURPOSE: The aim of this study was to investigate the anti-fibrotic effect of relaxin in subsynovial fibroblasts activated by transforming growth factor beta (TGF-β). MATERIALS AND METHODS: To test the anti-fibrotic... -
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- Orthopedic Manifestations of Type I Camurati-Engelmann Disease
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Yuldashev , Shin CH, Kim YS, Jang WY, Park MS, Chae JH, Yoo WJ, Choi IH, Kim OH, Cho TJ
- KMID: 2412312
- Clin Orthop Surg.
- 2017 Mar;9(1):109-115.
- doi: 10.4055/cios.2017.9.1.109
BACKGROUND: Camurati-Engelmann disease (CED) is a rare genetic skeletal disorder characterized by limb pain, muscle emaciation and weakness, and cortical thickening of the diaphysis of long bones. It is caused... -
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- Elk-3 Contributes to the Progression of Liver Fibrosis by Regulating the Epithelial-Mesenchymal Transition
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Li TZ, Kim SM, Hur W, Choi JE, Kim JH, Hong SW, Lee EB, Lee JH, Yoon SK
- KMID: 2412161
- Gut Liver.
- 2017 Jan;11(1):102-111.
- doi: 10.5009/gnl15566
BACKGROUND/AIMS: The role of Elk-3 in the epithelial-mesenchymal transition (EMT) during liver fibrogenesis remains unclear. Here, we determined the expression of Elk-3 in in vitro and in vivo models and... -
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- Angiopoietin-1 Modified Human Umbilical Cord Mesenchymal Stem Cell Therapy for Endotoxin-Induced Acute Lung Injury in Rats
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Huang ZW, Liu N, Li D, Zhang HY, Wang Y, Liu Y, Zhang LL, Ju XL
- KMID: 2374208
- Yonsei Med J.
- 2017 Jan;58(1):206-216.
- doi: 10.3349/ymj.2017.58.1.206
PURPOSE: Angiopoietin-1 (Ang1) is a critical factor for vascular stabilization and endothelial survival via inhibition of endothelial permeability and leukocyte- endothelium interactions. Hence, we hypothesized that treatment with umbilical cord... -
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- Genetic polymorphisms of interleukin-10 and transforming growth factor-β1 and antituberculosis drugs-induced liver injury
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Jung S, Kim SH, Sohn JW, Yoon HJ, Shin DH, Jee YK, Kim SH
- KMID: 2368575
- Allergy Asthma Respir Dis.
- 2017 Jan;5(1):41-46.
- doi: 10.4168/aard.2017.5.1.41
PURPOSE: Drug-induced liver injury is one of the serious adverse reactions resulting in severe morbidity and discontinuation of medications. Previously, IL-10 gene polymorphism has been reported to be associated with... -
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- Increased Cellular NAD⺠Level through NQO1 Enzymatic Action Has Protective Effects on Bleomycin-Induced Lung Fibrosis in Mice
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Oh GS, Lee SB, Karna A, Kim HJ, Shen A, Pandit A, Lee S, Yang SH, So HS
- KMID: 2365317
- Tuberc Respir Dis.
- 2016 Oct;79(4):257-266.
- doi: 10.4046/trd.2016.79.4.257
BACKGROUND: Idiopathic pulmonary fibrosis is a common interstitial lung disease; it is a chronic, progressive, and fatal lung disease of unknown etiology. Over the last two decades, knowledge about the... -
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- Renoprotective Effects of a Highly Selective A3 Adenosine Receptor Antagonist in a Mouse Model of Adriamycin-induced Nephropathy
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Min HS, Cha JJ, Kim K, Kim JE, Ghee JY, Kim H, Lee JE, Han JY, Jeong LS, Cha DR, Kang YS
- KMID: 2468272
- J Korean Med Sci.
- 2016 Sep;31(9):1403-1412.
- doi: 10.3346/jkms.2016.31.9.1403
The concentration of adenosine in the normal kidney increases markedly during renal hypoxia, ischemia, and inflammation. A recent study reported that an A3 adenosine receptor (A3AR) antagonist attenuated the progression... -
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- Simvastatin Reduces Capsular Fibrosis around Silicone Implants
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Chung KJ, Park KR, Lee JH, Kim TG, Kim YH
- KMID: 2373756
- J Korean Med Sci.
- 2016 Aug;31(8):1273-1278.
- doi: 10.3346/jkms.2016.31.8.1273
Capsular fibrosis and contracture occurs in most breast reconstruction patients who undergo radiotherapy, and there is no definitive solution for its prevention. Simvastatin was effective at reducing fibrosis in various... -
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- Apolipoprotein A1 Inhibits TGF-β1-Induced Epithelial-to-Mesenchymal Transition of Alveolar Epithelial Cells
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Baek AR, Lee JM, Seo HJ, Park JS, Lee JH, Park SW, Jang AS, Kim DJ, Koh ES, Uh ST, Kim YH, Park CS
- KMID: 2326682
- Tuberc Respir Dis.
- 2016 Jul;79(3):143-152.
- doi: 10.4046/trd.2016.79.3.143
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease characterized by the accumulation of excessive fibroblasts and myofibroblasts in the extracellular matrix. The transforming growth factor β1... -
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- Altered Biological Potential and Radioresponse of Murine Tumors in Different Microenvironments
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Lee IJ, Lee EJ, Park H, Kim W, Ha SJ, Shin YK, Seong J
- KMID: 2454351
- Cancer Res Treat.
- 2016 Apr;48(2):727-737.
- doi: 10.4143/crt.2014.350
PURPOSE: This study was conducted to evaluate the biological features of murine hepatocarcinoma according to different tumor microenvironmental models and to determine the change in molecular and immunologic responses after... -
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- Effects of Omega-3 Fatty Acids on Erectile Dysfunction in a Rat Model of Atherosclerosis-induced Chronic Pelvic Ischemia
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Shim JS, Kim DH, Bae JH, Moon DG
- KMID: 2363698
- J Korean Med Sci.
- 2016 Apr;31(4):585-589.
- doi: 10.3346/jkms.2016.31.4.585
The aim of this study was to investigate whether the omega-3 fatty acids help to improve erectile function in an atherosclerosis-induced erectile dysfunction rat model. A total of 20 male... -
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- All-Trans Retinoic Acid Has a Potential Therapeutic Role for Diabetic Nephropathy
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Kim CS, Park JS, Ahn CW, Kim KR
- KMID: 2345888
- Yonsei Med J.
- 2015 Nov;56(6):1597-1603.
- doi: 10.3349/ymj.2015.56.6.1597
PURPOSE: The aim of this study was to examine the effects of all-trans retinoic acid (ATRA) on diabetic nephropathy. MATERIALS AND METHODS: We measured amounts of urinary albumin excretion (UAE) after... -
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- Thalidomide Accelerates the Degradation of Extracellular Matrix in Rat Hepatic Cirrhosis via Down-Regulation of Transforming Growth Factor-beta1
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Lv P, Meng Q, Liu J, Wang C
- KMID: 2345885
- Yonsei Med J.
- 2015 Nov;56(6):1572-1581.
- doi: 10.3349/ymj.2015.56.6.1572
PURPOSE: The degradation of the extracellular matrix has been shown to play an important role in the treatment of hepatic cirrhosis. In this study, the effect of thalidomide on the... -
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- Clinical significance of increased vascular endothelial growth factor, transforming growth factor-beta1, and YKL-40 in the serum of children with asthma
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Jang YY, Lee HS, Jeong JE, Lee EJ, Hong SJ, Park HJ, Lee KH, Kim W, Chung HL
- KMID: 2218630
- Allergy Asthma Respir Dis.
- 2015 Nov;3(6):417-424.
- doi: 10.4168/aard.2015.3.6.417
PURPOSE: Vascular endothelial growth factor (VEGF), transforming growth factor beta1 (TGF-beta1), and platelet derived growth factor (PDGF) are known to be involved in the pathogenesis of inflammation and remodeling in... -
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- Wound Healing Effects of Rose Placenta in a Mouse Model of Full-Thickness Wounds
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Kim YW, Baek SR, Lee ES, Lee SH, Moh SH, Kim SY, Moh JH, Kondo C, Cheon YW
- KMID: 2152448
- Arch Plast Surg.
- 2015 Nov;42(6):686-694.
- doi: 10.5999/aps.2015.42.6.686
BACKGROUND: Rosa damascena, a type of herb, has been used for wound healing in Eastern folk medicine. The goal of this study was to evaluate the effectiveness of rose placenta... -
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