Genomics Inform.  2015 Dec;13(4):94-101. 10.5808/GI.2015.13.4.94.

Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases

Affiliations
  • 1Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA. xibao@utmb.edu
  • 2miRcore, Ann Arbor, MI 48105, USA.
  • 3Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA. yslee@utmb.edu
  • 4Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • 5The Institute of Translational Science, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • 6The Institute for Human Infections & Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA.

Abstract

tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles in several biological contexts such as cancer, innate immunity, stress responses, and neurological disorders. In this review, we summarize the biogenesis and functions of tRFs.

Keyword

neoplasms; neurodegenerative diseases; RSV replication, tRNA, tRNA-derived RNA fragments

MeSH Terms

Organelle Biogenesis*
Humans*
Immunity, Innate
Nervous System Diseases
Neurodegenerative Diseases
RNA*
RNA, Transfer
RNA, Untranslated
RNA
RNA, Transfer
RNA, Untranslated
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