Obstet Gynecol Sci.  2015 May;58(3):203-209. 10.5468/ogs.2015.58.3.203.

Practice patterns in the management of threatened preterm labor in Korea: A multicenter retrospective study

Affiliations
  • 1Department of Obstetrics and Gynecology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
  • 2Department of Obstetrics and Gynecology, Kangwon National University, School of Medicine, Chuncheon, Korea.
  • 3Department of Obstetrics and Gynecology, Konyang University College of Medicine, Daejeon, Korea.
  • 4Institute of Health & Science, Gyeongsang National University School of Medicine, Jinju, Korea.
  • 5Department of Obstetrics and Gynecology, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, Korea.
  • 6Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.
  • 7Department of Obstetrics and Gynecology, Eulji University College of Medicine, Daejeon, Korea.
  • 8Department of Obstetrics and Gynecology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
  • 9Department of Obstetrics and Gynecology, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Bucheon, Korea.
  • 10Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
  • 11Departments of Obstetrics and Gynecology and Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 12Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
  • 13Department of Obstetrics and Gynecology, The Catholic University of Korea College of Medicine, Seoul, Korea.
  • 14Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
  • 15Department of Obstetrics and Gynecology, St. Vincent's Hospital, The Catholic University of Korea College of Medicine, Suwon, Korea.
  • 16Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Seoul, Korea.
  • 17Department of Obstetrics and Gynecology, Yonsei University Health System, Seoul, Korea.
  • 18Department of Obstetrics and Gynecology, Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
  • 19Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea.
  • 20Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Catholic Kwandong University College of Medicine, Seoul, Korea.
  • 21Department of Obstetrics and Gynecology, Dankook University College of Medicine, Cheonan, Korea.
  • 22Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, Seoul, Korea. kkyj@ewha.ac.kr

Abstract


OBJECTIVE
This study aimed to examine clinical practice patterns in the management of pregnant women admitted with threatened preterm labor (TPL) in Korea.
METHODS
Data from women admitted with a diagnosis of TPL were collected from 22 hospitals. TPL was defined as regular uterine contractions with or without other symptoms such as pelvic pressure, backache, increased vaginal discharge, menstrual-like cramps, bleeding/show and cervical changes. Data on general patient information, clinical characteristics at admission, use of tocolytics, antibiotics, and corticosteroids, and pregnancy outcomes were collected using an online data collections system.
RESULTS
A total of 947 women with TPL were enrolled. First-line tocolysis was administered to 822 (86.8%) patients. As a first-line tocolysis, beta-agonists were used most frequently (510/822, 62.0%), followed by magnesium sulfate (183/822, 22.3%), calcium channel blockers (91/822, 11.1%), and atosiban (38/822, 4.6%). Of the 822 women with first-line tocolysis, second-line tocolysis were required in 364 (44.3%). Of 364 with second-line, 199 had third-line tocolysis (37.4%). Antibiotics were administered to 29.9% of patients (284/947) with single (215, 22.7%), dual (26, 2.7%), and triple combinations (43, 4.5%). Corticosteroids were administered to 420 (44.4%) patients. Betamethasone was administered to 298 patients (71.0%), and dexamethasone was administered to 122 patients (29.0%).
CONCLUSION
Practice patterns in the management of TPL in Korea were quite various. It is needed to develop standardized practice guidelines for TPL management.

Keyword

Clinical practical pattern; Pregnancy outcome; Premature birth; Threatened preterm labor

MeSH Terms

Adrenal Cortex Hormones
Anti-Bacterial Agents
Back Pain
Betamethasone
Calcium Channel Blockers
Dexamethasone
Diagnosis
Female
Humans
Korea
Magnesium Sulfate
Muscle Cramp
Obstetric Labor, Premature*
Physician's Practice Patterns
Pregnancy
Pregnancy Outcome
Pregnant Women
Premature Birth
Retrospective Studies*
Tocolysis
Tocolytic Agents
Uterine Contraction
Vaginal Discharge
Adrenal Cortex Hormones
Anti-Bacterial Agents
Betamethasone
Calcium Channel Blockers
Dexamethasone
Magnesium Sulfate
Tocolytic Agents
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