J Korean Soc Neonatol.  2010 May;17(1):84-93.

Risk Factors of Nosocomial Sepsis in Very Low Birth Weight Infants

• Kim CR
• Kim SY
• Park HJ
• Ki MR
• Yoon HS

Abstract

PURPOSE
This study was performed to estimate the incidence of nosocomial sepsis and to identify the most relevant risk factors for nosocomial sepsis in high-risk very low birth weight (VLBW) infants.
METHODS
A retrospective review of 341 VLBW infants, admitted to the Neonatal Intensive Care Unit of the Eulji University Hospital (Daejeon & Seoul) between January 2002 and June 2009, who survived more than 72 hours was performed. The incidence, causative organisms, risk factors and prognosis of nosocomial sepsis in VLBW infants were analyzed.
RESULTS
The incidence of nosocomial sepsis was 16.1% and the onset date of nosocomial sepsis was 21.5+/-15.9 days (mean+/-SD) after delivery. Staphylococcus aureus (21.3%) was the most common organism in the patients with nosocomial sepsis in VLBW infants. The multiple logistic regression analysis showed that, gestational age [odds ratio (OR), 0.87; 95% CI, 0.83-0.91], umbilical artery catheter use for more than 5 days (OR, 2.2; 95% CI, 1.15-4.46), umbilical venous catheter use for more than 5 days (OR, 2.1; 95% CI, 1.11-4.16), peripheral arterial line use (OR, 2.1; 95% CI, 1.14-4.04) and intravenous intralipids (OR, 4.3; 95% CI, 1.13-14.32) were identified as risk factors.
CONCLUSION
The limited usage of intravascular catheter related procedures and the short providence of intravenous nutrition may decrease the incidence of nosocomial sepsis in VLBW infants.

Keyword

Nosocomial infection; Very low birth weight infant; Risk factor

MeSH Terms

Catheters
Cross Infection
Gestational Age
Humans
Incidence
Infant
Infant, Newborn
Infant, Very Low Birth Weight
Intensive Care, Neonatal
Logistic Models
Prognosis
Retrospective Studies
Risk Factors
Sepsis
Staphylococcus aureus
Umbilical Arteries
Vascular Access Devices