Korean J Med.
1998 Mar;54(3):441-445.
Bone Marrow Necrosis in CD7 positive Acute Myeloid Leukemia
- Affiliations
-
- 1Department of Internal Medicine, Dongguk University, Kyong Ju Hospital, Kyongju, Korea.
- 2Department of Pathology, Dongguk University, Kyong Ju Hospital, Kyongju, Korea.
- 3Department of Clinical Pathology, Dongguk University, Kyong Ju Hospital, Kyongju, Korea.
Abstract
-
Bone marrow necrosis is infrequently diagnosed during
life, and its presence often signifies a poor prognosis. It
has been associated with a variety of disease, including
acute and chronic leukemia, carcinoma, malignant lymph
oma, infection and sickle cell disease. About 5-26% of
acute myeloid leukemia has been reported to express
lymphoid differentiation markers, of which CD7 is ex
pressed very early during T-cell ontogeny.
A 46-year-old male complaining severe bone pain had
pancytopenia, leukoerythroblastosis and bone marrow
necrosis. Peripheral blood immature cells expressed CD7
as well as myeloid markers such as CD13 and CD33 on
immunophenotypic studies.
We report a case of CD7 positive acute myeloid leu
kemia associated with bone marrow necrosis, confirmed
by bone marrow biopsy and immunophenotypic study.