Korean J Med.  1998 Mar;54(3):441-445.

Bone Marrow Necrosis in CD7 positive Acute Myeloid Leukemia

Affiliations
  • 1Department of Internal Medicine, Dongguk University, Kyong Ju Hospital, Kyongju, Korea.
  • 2Department of Pathology, Dongguk University, Kyong Ju Hospital, Kyongju, Korea.
  • 3Department of Clinical Pathology, Dongguk University, Kyong Ju Hospital, Kyongju, Korea.

Abstract

Bone marrow necrosis is infrequently diagnosed during life, and its presence often signifies a poor prognosis. It has been associated with a variety of disease, including acute and chronic leukemia, carcinoma, malignant lymph oma, infection and sickle cell disease. About 5-26% of acute myeloid leukemia has been reported to express lymphoid differentiation markers, of which CD7 is ex pressed very early during T-cell ontogeny. A 46-year-old male complaining severe bone pain had pancytopenia, leukoerythroblastosis and bone marrow necrosis. Peripheral blood immature cells expressed CD7 as well as myeloid markers such as CD13 and CD33 on immunophenotypic studies. We report a case of CD7 positive acute myeloid leu kemia associated with bone marrow necrosis, confirmed by bone marrow biopsy and immunophenotypic study.

Keyword

Bone marrow necrosis; Acute myeloid; leukemia; CD7
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