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Characteristics of DNMT3A mutations in acute myeloid leukemia

Park DJ, Kwon A, Cho BS, Kim HJ, Hwang KA, Kim M, Kim Y

BACKGROUND: DNMT3A mutations occur in approximately 20% of AML cases and are associated with changes in DNA methylation. CDKN2B plays an important role in the regulation of hematopoietic progenitor cells...
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Bibliometric analysis of studies about acute myeloid leukemia conducted globally from 1999 to 2018

Seo B, Kim J, Kim S, Lee E

A bibliometric study is performed to analyze publication patterns in a specific research area and to establish a landscape model that can be used to quantitatively weigh publications. This study...
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Posaconazole versus Itraconazole as Prophylactic Antifungal Agents during Induction Chemotherapy for Acute Myeloid Leukemia: A Real-World Single Center Comparison

Kim C, Yoon SY, Lee MY, Kim KH, Lee N, Won JH

OBJECTIVE: To prevent invasive fungal disease (IFD) in acute myeloid leukemia (AML) patients, the use of posaconazole as a prophylactic antifungal agent has become standard in patients undergoing induction chemotherapy....
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Favorable long-term survival using consolidation chemotherapy without allogeneic hematopoietic cell transplantation for acute myeloid leukemia with wild-type NPM1 without FLT3-ITD

Baek DW, Lee JM, Kim JH, Cho HJ, Ham JY, Suh JS, Sohn SK, Moon JH

BACKGROUND: The role of allogeneic hematopoietic cell transplantation (allo-HCT) compared with consolidation chemotherapy alone in intermediate-risk acute myeloid leukemia (AML) patients with wild-type nucleophosmin/negative or a low level of Fms...
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Mesenchymal stem cells in acute myeloid leukemia: a focus on mechanisms involved and therapeutic concepts

Fathi E, Sanaat Z, Farahzadi

Drug resistance in cancer, especially in leukemia, creates a dilemma in treatment planning. Consequently, studies related to the mechanisms underlying drug resistance, the molecular pathways involved in this phenomenon, and...
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Concurrent Leukemia Cutis and Sweet Syndrome in a Patient with Acute Myeloid Leukemia

Kim TL, Jang JW, Shin DS, Kang HS, Seo HM, Kim JS

  • KMID: 2454384
  • Korean J Dermatol.
  • 2019 Jul;57(6):350-352.
No abstract available.
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A Rare Case of Acute Myeloid Leukemia With SET-NUP214 Fusion and Massive Hyperdiploidy

Jeong IH, An GD, Lim HH, Woo KS, Kim KH, Kim JM, Lee JH, Han JY

No abstract available.
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FLT3 Internal Tandem Duplication in Patients With Acute Myeloid Leukemia Is Readily Detectable in a Single Next-Generation Sequencing Assay Using the Pindel Algorithm

Kim B, Kim S, Lee ST, Min YH, Choi JR

No abstract available.
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Reclassification of Acute Myeloid Leukemia According to the 2016 WHO Classification

Jung J, Cho BS, Kim HJ, Han E, Jang W, Han K, Lee JW, Chung NG, Cho B, Kim M, Kim Y

We reviewed our leukemia database to reclassify 610 patients previously diagnosed as having acute myeloid leukemia (AML) according to the updated 2016 WHO classification. Nine patients were categorized as having...
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Granulocytic Sarcoma of the Sciatic Nerve Manifested as Relapse of Acute Myeloid Leukemia: A Case Report

Lee SE, Chong Y, Song SW, Park J

Granulocytic sarcoma is a form of extramedullary involvement of primitive myeloid cells. A 69-year-old male patient, with history of acute myeloid leukemia (AML) in remission state for 4 years, presented...
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Establishment and operation of a cooperative program to identify work-related acute myeloid leukemia in a general hospital

Jung J, Choi HR, Cho BS, Park S, Myong JP, Kang MY, Kim HJ

BACKGROUND: The purpose of this report is to introduce the occupational cancer surveillance system, implemented in June 2018, and to share the results of our cooperative program. METHODS: The cooperative program...
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Small RNA sequencing profiles of mir-181 and mir-221, the most relevant microRNAs in acute myeloid leukemia

Lee YG, Kim I, Oh S, Shin DY, Koh Y, Lee KW

BACKGROUND/AIMS: To evaluate and select microRNAs relevant to acute myeloid leukemia (AML) pathogenesis, we analyzed differential microRNA expression by quantitative small RNA next-generation sequencing using duplicate marrow samples from individual...
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Overexpression of indoleamine 2,3-dioxygenase correlates with regulatory T cell phenotype in acute myeloid leukemia patients with normal karyotype

Arandi N, Ramzi M, Safaei F, Monabati A

BACKGROUND: Production of immunosuppressive enzymes such as indoleamine 2,3-dioxygenase (IDO) is one of the strategies employed by hematologic malignancies, including acute myeloid leukemia (AML), to circumvent immune surveillance. Moreover, IDO...
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The Pharmacological Inhibition of ERK5 Enhances Apoptosis in Acute Myeloid Leukemia Cells

Kang C, Kim JS, Kim CY, Kim EY, Chung HM

Acute myeloid leukemia (AML) is a fatal hematological malignancy which is resistant to a variety of chemotherapy drugs. Extracellular signal-regulated kinase 5 (ERK5) plays a novel role in chemoresistance in...
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Posaconazole for Prophylaxis of Fungal Infection in Pediatric Patients with Acute Myeloid Leukemia undergoing Induction Chemotherapy

Kim SM, Ree YS, Kim JS, Kim SH, Son ES, Lyu CJ

BACKGROUND: Posaconazole is a broad-spectrum triazole antifungal agent and the most recommended prophylactic antifungal agent for patients with acute myeloid leukemia (AML) undergoing induction chemotherapy. In this study, we evaluated...
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PCM1-JAK2 Fusion in a Patient With Acute Myeloid Leukemia

Lee JM, Lee J, Han E, Kim M, Kim Y, Han K, Kim HJ

No abstract available.
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Spectrum of mitochondrial genome instability and implication of mitochondrial haplogroups in Korean patients with acute myeloid leukemia

Kim HR, Kang MG, Lee YE, Na BR, Noh MS, Yang SH, Shin JH, Shin MG

BACKGROUND: Mitochondrial DNA (mtDNA) mutations may regulate the progression and chemosensitivity of leukemia. Few studies regarding mitochondrial aberrations and haplogroups in acute myeloid leukemia (AML) and their clinical impacts have...
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The prognostic impact of lymphocyte subsets in newly diagnosed acute myeloid leukemia

Park Y, Lim J, Kim S, Song I, Kwon K, Koo S, Kim J

BACKGROUND: Tumor-infiltrating lymphocytes, which form a part of the host immune system, affect the development and progression of cancer. This study investigated whether subsets of lymphocytes reflecting host-tumor immunologic interactions...
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Improvement of treatment outcome over 2 decades in children with acute myeloid leukemia

Song TY, Lee SH, Kim G, Baek HJ, Hwang TJ, Kook H

BACKGROUND: The prognosis of pediatric acute myeloid leukemia (AML) has recently improved. This study aimed to describe the epidemiology, changes in treatment strategies, and improvement of outcomes in Gwangju-Chonnam children...
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Current treatment for pediatric acute myeloid leukemia

Im HJ

No abstract available.
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